Name Amitriptyline TCA

Indications Depression

Contraindications Myocardial infarction Arrhythmias Mania

Adverse effects Antimuscarinic Anxiety Dizziness

Citalopram SSRI

Depression

Mania MAOI

GI effects Rash Drowsiness Dry mouth

Lithium Mood stabiliser

Bipolar disorder

Dehydration Untreated hypothyroidism

Weight gain GI effects Renal impairment

Ibuprofen NSAID Levodopa + carbidopa

Pain and inflammation Parkinsons

Hypersensitivity Active GI bleeding or history of MAOI use Angle-closure glaucoma

GI discomfort Asthma Nausea and vomiting Dry mouth Drowsiness Dyskinesia Extrapyramidal Drowsiness

Interactions CYP3A4 Antiarrhythmic (e.g. Amiodarone) Antiepileptics (antagonises) MAO inhibitors Tramadol CYP3A4 MAOI Sumatriptan (serotonin agonist) Lithium Tramadol SJW NSAIDs ACE inhibitors Antiarrhythmic SSRIs Diuretics (esp. thiazides) NSAIDs SSRIs (bleeding) Lithium MAOIs Anaesthetics

Metoclopramide Antiemetic

Nausea

Carbamazepine Antiepileptic Tonic-clonic seizures

GI obstruction Drugs which cause extrapyramidal effects Avoid in Parkinsons MAOIs Bone marrow depression AV conduction abnormalities

Cyclosporin Dopamine agonists

Clonazepam Benzodiazepine Antiepileptic

Epilepsy

Respiratory depression Sleep aponea Pulmonary insufficiency

Dry mouth Nausea and vomiting Hyponatremia Oedema Blood disorders Rash Drowsiness Amnesia Poor concentration Dependence and withdrawal

CYP3A4 TCA MAOIs SSRIs SJW

Selegiline (MAO-B) Clozapine Olanzapine