AGENTS TO TREAT HERPES SIMPLEX VIRUS & VARICELLAZOSTER VIRUS INFECTIONS

Varicella-zoster virus infection:

Varicella-zoster virus infection:

Anti HSV & VZV agents

Classification of Antiviral Agent (nonretroviral)

Anti influenza agents

Other antiviral agents

Anti-HSV and VZV Agents

Acyclovir : PK

Untoward Effects Topical acyclovir: mucosal irritation Oral: nausea, diarrhea, rash, headache renal insuff, neurotoxicity IV: renal insuff, CNS

Therapeutic Uses - better clinical benefit - in initial infection than in recurrent - in HSV than VZV

Cidofovir

FOSCARNET
A broad in vitro antiviral activity. Apporoved for CMV retinitis in immunocompromised hosts and acyclovir-resistant HSV and HZV inf Reversibly inhibiting viral DNA and RNA polymerases, thereby terminating c haine longation mutation of polymerase structure Poorly absorbed orally and must be injected IV Distrib: throughout the body, > 10% enters the bone matrix Eliminated: tubular secretion into the urine ADR: nephrotoxicity, anemia, nausea, and fever. Hypocalcemia and hypomagnesemia are also seen