APPLICATION OF SPSS

M.Salman Bashir
Biostatistics Officer
Clinision – a research division of PharmEvo
INTRODUCTION
 SPSS is a software package used for conducting
statistical analysis, manipulating data, and generating
table and graphs that summarize data.
 SPSS performs statistical analysis range from basic
descriptive statistics, such as average and prevalence,
to advanced inferential statistical, such as regression
model, analysis of variance (ANOVA), factor analysis
etc.
 SPSS also contains several tools for manipulating
data, including functions for recording data, macros
programming on visual basic editor, merging data, and
aggregating complex data sets.
FEATURES AND BENEFITS

For Small And Medium Enterprises (SME)

 Resources & best practices.
 Techniques for cleaning data.
 Access Data in Relational Databases.

For Large Scale Enterprises (LSE)

 Real time processing and online mapping.
 Online Database connectivity different networks.
 Data import & export data from different medium like SAS,
Statistica.
 Compliances and Validations.
What are the options?
 Many commercial products available
SAS, Statistica, Minitab, and others
 Excel
Widely available (part of MS Office Suite)
Not a statistical software – spreadsheet
Finance, math, and statistics applications

 SPSS
Robust software for sophisticated statistical applications
Upgrade with add-ins
WHY SPSS?
 Strengths
 Very robust statistical software
 Many complex statistical tests available
 Good “stats coach” help with interpreting results
 Easily and quickly displays data tables
 Can be expanded
 Using the syntax feature
 Purchasing add-ins

 Limitations
 Can be expensive
 Not intuitive to use
 Typically requires additional training to maximize
features (at a cost)
 Graphing feature not as simple as Excel
RESEARCH & DEVELOPMENT
SPSS given the technique of specialize in design, development,
and implementation of corporate analytical and data mining
solution integrated with the existing data acquisition and storage
of systems. Its continuously given the solution in Pharmaceutical
and Medical research.
 Quality and Manufacturing.
 Compliance and Validation..
 Empower Researcher with Tools.
 Regulatory Safety Testing.
 Clinical Trails.
 Data Mining in Drug Discovery.
QUALITY AND MANUFACTURING

SPSS can provide a single, standardized quality control and

improvement solution that can be easily validated that cover the
whole range of manufacturing statistics, including simple
descriptive statistics and graphics, QC charting, capability
analyses for normal and Non-normal distributions, design of
experiment (DOE) much more.
• Online and offline SPC (Statistical Process Control)
• Process Capability Analysis.
• Measurement System Analysis.
• Design of Experiment
• Process Validation.
COMPLIANCE AND VALIDATION

SPSS offers a pre-validation core platform with fully secure user

administration and configuration control, audit trails on system
configuration changes, data manipulation, analysis results and
integrated data modules. Together these features can radically
change the way of your organization works and remove the need
for extensive manual documentation of analytical processes.
• Validation of Software.
• Analysis of Audit Trails.
• Computer Systems Validation
EMPOWER RESEARCHER WITH TOOLS
Even small improvement in research and development process
directly affect an organization’s bottom line and many
pharmaceuticals research organizations have experienced the
positive impact of deploying SPSS. Offering a choice of desktop
(stand-alone), networks, and server based analytical platforms.
Statistician has provided analytical tools that are easy to use,
relevant and integrated with their data sources.
• Comprehensive Statistical Test & Graphical Tools.
• Efficient use of limited Statistician & Training Resources.
• Integrated with Existing System & Data Sources.
• Rapid return on investment.
REGULATORY SAFETY TESTING

From simple bioassay and dose-response experiments to long-

term survival and carcinogenicity studies, SPSS has the tools to
handle your data. Where the standard study designed are used.
SPSS tools provides the most efficient mechanism for automating
and validating routine analysis report.

• Power and Sample Size Calculation.

• Predictive Data Mining.
• Forecasting and Report Generation.
• Analysis of Complex Drug’s Assay.
CLINICAL TRIALS
Ethical considerations and at least in Phase I and Phase II
Studies small sample sizes make it imperative that the most
power statistical methods be used in ordered to established
efficacy and detect side effects.
SPSS is unique in providing a fully document management
system along with complete analytical toolkit. With ability to
directly query standard database platforms and to import a wide
range of data file format (including SAS files).
• Generalized Linear and Non-Linear Model
• Variance Component Estimations (ANOVA).
DATA MINING IN DRUG DISCOVERY

With the advent of new technologies that allow very large amounts
of data to be captured and stored automatically many new
challenges are presented. In application of classical statistical
methods many were developed specially to extract the maximum
amount of information from minimal data sets. According to the
FDA Critical Path Initiative the use of data mining technology and
methodology is central to improvement discovery, pre-clinical and
clinical research. SPSS perform a excellent crunch the complex
data sets.
• Handle Huge Data Sets with Ease.
• Exploratory Data Mining Techniques.
• Comprehensive Data Mining Toolkit.
SUMMARY
 Industry standard process
 Open system
 Easy to use graphic interface
 Flexibility
 Productivity
Questions!