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1: Arch Surg. 1986 Dec;121(12):1421-4.

Chemoprevention of colorectal neoplasms. Ascorbic acid and beta-carotene. Related Articles

Antioxidants vs carotenoids. Inhibitors or promoters of

Colacchio TA, Memoli VA. experimental colorectal cancers. [Arch Surg.1989]

The organospecific, 1,2-dimethylhydrazine-induced rat tumor model was used to test tumor Effect of beta-carotene, sodium ascorbate and cellulose on
formation in groups of animals receiving regular chow, powdered chow with 7%/wt ascorbic acid [CancerinLett.
1,2-dimethylhydrazine-induced intestinal carcinogenesis 1994]
rats.
supplement, pelleted chow with 1%/wt beta-carotene supplement, and pelleted chow with Effect of beta-carotene and wheat bran fiber on colonic aberrant
placebo beadlets. Following a 16-week induction period, animals were killed and tumor [Carcinogenesis
crypt and tumor formation in rats exposed to azoxymethane and.1995]
formation was recorded. Tumor formation in the ascorbic acid supplement group was found to be
Low doses of beta-carotene and lutein inhibit AOM-induced rat
significantly less than the control group. The beta-carotene group showed no difference in tumor
colonic ACF formation but high doses augment ACF [Inincidence.
t JCancer.2005]
formation compared with the placebo-beadlet control group. Tumor incidence was generally the
same between the two control groups, and the ascorbic acid group had significantly fewer Review Colorectal cancer in animal models--a review.
tumors than the beta-carotene group. In sum, ascorbic acid supplements in high doses [J Surg Res .1987]
significantly decreased tumor formation, whereas beta-carotene supplements in moderately high
» See Reviews... | » See All...
doses had no effect on tumor formation in this model.

PMID: 3789912 [PubMed - indexed for MEDLINE] Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)

Ascorbic acid is used to prevent and treat scurvy, a disease
caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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Chemoprevention of colorectal neoplasms. Ascorbic acid

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Dietary antioxidants and the risk of lung cancer.