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Whats a Drug?
procaine morphine botulinum toxin
nicotine
CH3 N
Brain
Bottom ventral
Spinal cord
presynaptic neuron
Nestler, Hyman, Malenka, Molecular Neuropharmacology, McGraw-Hill Professional Publishing g
postsynaptic neuron
Box 2 - 2 Figure A
An adult human brain contains ~ 1011 neurons, and each of these might receive 103 synapses apiece, apiece for a total of 1014 synapses. Most of these synapses form during the first 2 yr of life. Thus 1014synapses/108 s = 106 synapses/s form in a fetus and infant!
Binding region
Membrane region
Cytosolic eg o region
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=32169
Drug receptors are proteins. Heres the acetylcholine binding protein interfacial aromatic box occupied by nicotine
Y198 C2
W149 B
Y93 A
Y190 C1
non-W55 D
Ligand-binding region
acetylcholine or nicotine
acetylcholine or nicotine
acetylcholine or nicotine
M1 M2 M3
M4
Drug Receptor
current
time
GTP GDP + Pi
inside
Downstream from GPCRs are intracellular messengers. We have several ways to measure them. Live-cell Live cell imaging is one way. Biochemistry is another. Fluorescence Microscopy
Drugs Drugs and the Brain Brain See two items on the course Web site: Henry Lesters sources of research funding; and the disclaimer about medical advice End of Organization and overview module, part A
2012 California Institute of Technology