Bullous pemphigoid Bullous pemphigoid is a chronic autoimmune condition in which subepidermal blisters develop due to a circulating IgG autoantibody

directed against antigens in the dermoepidermal junction. Bullous pemphigoid is predominantly a disease of the elderly. Tense blisters develop on erythematous urticarial areas, especially on the flexural aspects of the limbs. The lesions may be very itchy and the blisters may become large and remain intact for days, sometimes becoming haemorrhagic. The face and scalp are not usually affected, but the oral mucosal may develop small blisters. Nikolskys sign is negative.