Injectable is composed of micronized, dehydrated amniotic
membrane allograft that provides anti-inammatory cytokines and growth factors for enhanced soft tissue healing. Injectable Micronized Amniotic Membrane Allograft for Enhanced Soft Tissue Healing !"#$%&'()$ !"#$% & Description AmnioFix Injectable is composed of micronized amniotic tissue, uniquely processed to optimize surgical performance and ease of use. The proprietary Purion, SM
Process retains the amniotic growth factors and cytokines inherent in this tissue. The result is an injectable product that offers surgeons a clear advantage. Conta|ns a comb|nat|on ol rowtH factors unique to placental tissue beduces |nNammat|on at tHe |nject|on s|te LnHances tHe norma| wound Hea||n process Anti-Inammatory and Healing Properties In vivo and in vitro studies have shown that the properties of amniotic membrane help to reduce |nNammat|on and solt t|ssue healing. 1,2,3,4 Nat|ve 0rowtH be|at|ve /mount be|ease lroh|e Factors Present Determined by Initial (w/in 11 minutes) ELISA Assay Delayed (after 11 minutes) PDGF-AA +++++ PDGF-BB + bFGF ++ TGF-b1 ++ EGF + Inammation Reduction Human amniotic tissue has been proven to conta|n ant| |nNammatory prote|ns sucH as interleukin (IL)-1 receptor antagonist; tissue inhibitors of metalloproteinase (TIMPs) -1, -2, -4; IL-4 and IL-10. 1,2,3,4 Growth Factors Growth Factors contained in Purion processed dehydrated amniotic membrane, relative amounts and re|ease proh|e. Safety and Ease of Use AmnioFix Injectable is processed using Purion, a unique approach that provides an added level of tissue safety and ease of use. Lllect|ve m|crob|a| reduct|on, us|n Purion Process 0eHydrated, m|cron|zed membrane lor simple mixing and application byear sHe|l ||le at room temperature; no special storage required 0ver 4b,CCC Human membrane |mp|ants to date AmnioFix
is a registered trademark of MiMedx Group, Inc. www.mimedx.com
/mn|ol|x |s processed by 3ur|ca| B|o|o|cs, a l|ledx 0roup Company. bC CHasta|n Center B|vd., 3u|te bC, bennesaw, 0/ 3C44 ZCZ l|ledx 0roup, lnc. /|| b|Hts beserved. /lb.CCZ beduces lnNammat|on Enhanced Soft Tissue Healing Non-Immunogenic Item Number Size /lbCbC C.bm| /lbZb .Zbm| /lbZCC Z.Cm|
1 3o|omon /, bosenb|att l, lonroy 0. 3uppress|on ol |nter|euk|n a and |nter|euk|n |n Human ||mba| ep|tHe||a| ce||s cu|tured on tHe amn|ot|c membrane stroma| matr|x. Br J 0pHtHa|mo| ZCC;b:444449. 2 3H|mmura 3, 3H|mazak| J, 0HasH| Y, 1subota b. /nt||nNammatory ellects ol amn|ot|c membrane transp|antat|on |n ocu|ar surlace d|sorders. Cornea ZCC;ZC:4C3. 3 1oda /. et a| 1He lotent|a| ol /mn|ot|c lembrane//mn|on0er|ved Ce||s lor beenerat|on ol Var|ous 1|ssues. J. lHarmaco| 3c| Cb |ZCC/, ZbZZ 4 Hao Y, la 0H, Hwan 00, b|m w3, ZHan l. ldent|hcat|on ol ant|an|oen|c and ant||nNammatory prote|ns |n Human amn|ot|c membrane. Cornea. ZCCC;9:34-3bZ. !"#$%&'()$ !"#$% & Ordering Information Customer 3erv|ce: bb.4//.4Z9 Lma||: customerserv|ce@m|medx.com www.amn|ohx.com/|njectab|e Product Offering leasured by Lll3/ test|n un|ysed and |ysed t|ssue |n suspens|on 21% 46% 47% 41% 50% 79% 54% 53% 59% 50% Non-immunogenic Human amniotic tissue is non-immunogenic and does not elicit a substantial immune response