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43
Indian Medicinal Plants in Trade Medherb Green Pages - India and Indonesia 2009
INDIAN MEDICINAL PLANTS IN TRADE there was a least chance of using material other than the genuine
one as medicine. But present day scenario is entirely different and
(A case study of adulterants and their identification)
has gone dramatic change during the last century on account of the
shift of manufacturing process from home scale produce to
Abstract
industrial production and most of the herbal practitioners and plant
Out of about 46,000 plant species described in India around
based Pharmaceutical Companies largely depend upon the crude
6000 species are used as medicinal plants in all the codified and non
drug dealers and traders to meet their requirement of raw materials.
codified systems of medicine prevalent in India. From these, 2400
Today over 700 manufactured products are prepared by more than
species are documented in codified medicinal systems namely
9000 licensed manufacturing units in India and the annual domestic
Ayurveda, Siddha, Unani, Swa-rigpa (Tibetan), Homoeopathy and
consumption by the Indian herbal Industry during the year 2005-
Western and 3600 species are exclusively used by ethnic
2006 was 1,70,000 MT (Ved & Goraya, 2007). Because of wide spread
communities across the various ecosystems in the country. Around a
belief that herbal medicines are safer than synthetic drugs, demand
1000 species used by codified systems are also used by the ethnic
of medicinal plants has increased many fold in the national and
communities. Thus, the ethnic communities totally use around 4600
international markets. Besides, demands of medicinal plants are also
species. Out of these 6000 medicinal plants 960 species are in trade
increasing to meat the needs of modern medicines, nutraceuticals,
for manufacturing medicines by more than 9000 licensed
food supplements, herbal cosmetics, and toiletry products in
manufacturing units all over the country.
national and international markets. It is estimated that the current
Under the crude drug identification services of NISCAIR, 3586
domestic turnover of herbal products in India is in between Rs. 7000
crude drug samples have been received for identification from
to 8000 crores per annum. Foreign trade related to finish herbal
various plant based pharmaceutical companies, traders of
products as well as raw materials is Rs. 3,600 crores per annum.
medicinal plants, crude drug dealers, research students and
Further, the domestic as well as export turnover of herbal products
teachers from various Universities, Colleges of Pharmacy, and
in India will increase up to Rs. 14,500/- and 9,000/- crores
scientists from various Research Institutions, during April 1998 to
respectively by 2012 (Anonymous, 2008).
November 2008. Out of them, 401 samples have been found
botanically erroneous. The usage of such adulterated or spurious
Thus the commercial exploitation of medicinal plants at global
raw materials for manufacturing medicine in place of genuine one is
level has shown tremendous growth making it a 68 Billion US $
responsible for lowering quality and efficacy of the drug because the
industry with about 30% annual growth, which is expected to touch
adulterated material may not have the active compound. Moreover,
one trillion US $ by 2020 and 5 Trillion US $ by the years 2050 (Singh,
it may have toxic compound that may cause deleterious effect on
2007).
human health. Consequently, reliability of the finished products at
national and international level is affected and betraying the faith of
As cultivation of medicinal plants in India is limited, over 90
people on Indian Systems of Medicine.
percent medicinal plants are being harvested from the wild habitats
For the protection of consumer's interest, correct botanical
to meet ever-growing demands of national and international
identity of the crude drug is essential. Unfortunately there is no
market. But, due to various natural and man made factors like earth
single method to assure 100 per cent correct identification of the
quakes, landslides, Tsunamy, floods, draughts, Forest wildfires,
crude drug material but the goal can be achieved through the
population growth, urbanization, industrialization, mining,
application of a variety of different methodologies. The whole construction of highways, dams, introduction of exotic species,
process starts with from the collection of the material and keeping increase in agriculture land, slash or burn agriculture practices,
good voucher specimens that act as reference material followed by grazing, over exploitation, injudicious or unscientific collection from
macroscopic and microscopic examinations, Chemical analysis and wild, illegal trade in endangered species, etc. natural habitats of
DNA-based techniques. Therefore, the present study suggests that medicinal plants are destroying. As a result, natural population of
correct botanical identity and authenticity of the crude drug medicinal plants is depleting. Recently, International Union for
materials must be ensured before using the same for preparing Conservation of Nature and Natural Resources (IUCN) has reported
medicine. that over 200 Indian medicinal plants have come at the verge of
danger of threat (Singh, 2007). Consequently, availability of these
Introduction medicinal plants is decreasing. Due to less availability of medicinal
Crude drugs are the starting raw material for manufacturing plants and high demand of these plants, there is a gap in demand
herbal medicines. Efficacy of any medicine depends on the and supply that lead to adulteration and substitution for genuine
genuineness and quality of the raw materials used for its material. The works carried out on identification of spurious crude
preparation. In the days of yore, Vaidyas or Hakims were well drugs have been reviewed by Mehrotra et al (2003). Singh & Kumar
acquainted with the herbs used by them as medicine for treatment (2005) are of the opinion that about 9.48 percent crude drug
of an ailment. They were not only used to collect medicinal plants samples found spurious in the market. The usages of such
from the nearly forests, but also preparing various drug adulterated or spurious raw materials for manufacturing medicine
formulations themselves as per needs of the patients. Therefore, deteriorate the quality and efficacy of the finished product.
Moreover, the adulterants may be having toxic compounds that may Materials and methods
produce deleterious effect on human health. Because of this, Under the crude drug identification services, 3486 crude drug
reliability of the finished products at national and international level samples have been received during April 1998 to November 2008
is affected and betraying the faith of people on Indian System of for identification, either in botanical name(s) or in Trade, local or
Medicine. For instance, recently, countries like USA, Canada, and English name(s), from various plant based pharmaceutical
European Union have imposed ban on consumption of some of the companies, traders of medicinal plants, crude drug dealers, research
Indian Ayurvedic medicines.
students, faculty members of various universities and pharmacy
colleges, and scientists of research institutions. These samples are
Keeping in view the above, National Institute of Science
deposited in RHMD for future references.
Communication And Information Resources (NISCAIR), a
constituent establishment of the Council of Scientific & Industrial
Research (CSIR), New Delhi has set up Raw Materials Herbarium & Soon after receiving the crude drug sample(s) they have been
Museum Delhi (RHMD). The RHMD has been recognized by the studied under binocular microscope (BM) for their physical
Index Herbariorum, New York, USA, a constituent establishment of appearance followed by soaking them in lukewarm water for 2-4
the International Association of Plant Taxonomists (IAPT) and New hours, depending upon the hardness of the material, for softening
York Botanical Gardens, USA. The acronym RHMD has been allotted tissues. The techniques for studying macroscopic and microscopic
to it by them. characters were followed by Stace (1965), Gupta (2003) and Lohar
(2007). The characters observed under microscope were matched
RHMD houses over 7000 authentic Herbarium specimens, 2200 with the characters described in published literature like the Wealth
crude drug samples, 200 Zoological specimens and 225 mineral of India, an encyclopedia of raw materials, the Ayurvedic
samples, which have been acquired by donation from the regional Pharmacopoeia of India, the Unani Pharmacopoeia of India,
centres of Botanical Survey of India (BSI), Zoological Survey of India Illustrated manual of herbal drugs used in Ayurveda, Indian Materia
(ZSI), Geological Survey of India (GSI), Central Council for Research Medica, Indian Medicinal Plants, and various regional, state and
in Ayurverda & Siddha (CCRAS), and from the national laboratories national floras. For checking English, regional or trade names,
like National Botanical Research Institute, (NBRI), Lucknow, Central besides the above said books, Torkelson (1999) and Kareem (1997)
Drug Research Institute (CDRI), Lucknow, Forest Research Institute, have also been followed. To ensure correct identity, detailed
Dehradun, North –East Institute of Science & Technology, (NEIST)
comparative studies of the sample(s) received for identification were
Jorhat, Indian Institute of Integrative Medicine, (IIIM), Jammu,
carried out with those authentic crude drug samples deposited in
Institute of Minerals & Metals (IMMT), Bhubaneswar and several
RHMD.
other departments of various Universities, and also collected
through field collections by our staff from all over the country.
These authentic samples have been preserved in RHMD and being Results
used as standard reference materials while identifying the crude Results obtained after critical study of the crude drug samples
drug samples. received for identification are given in Tables I , II and III.
Table 1 :
Year-wise breakup of samples received and identified during Apr. 1998 to Nov. 2008, and the percentage of samples found incorrect.
Sl no. Year No. of samples No. of samples No. of samples found Percentage of
received found correct spurious /incorrect spurious samples
1. 1998-1999 88 68 20 22.72
2. 1999-2000 72 59 13 18.05
3. 2000-2001 188 173 15 7.97
4. 2001-2002 232 217 15 6.46
5. 2002-2003 316 291 25 7.91
6. 2003-2004 312 268 44 14.10
7. 2004-2005 323 292 31 9.59
8. 2005-2006 718 649 69 9.61
9. 2006-2007 426 388 38 8.92
10. 2007-2008 401 326 75 18.70
11. 2008-2009 410 354 56 13.65
Total 3486 3085 401 11.50
(Average)
Table 2 :
Samples received by botanical name(s) identified as incorrect
Sl no. Probable trade name Sample received as Part Sample identified as
1 Biranjasif, Gandana Achillea millefolium Linn. Seeds Pimpinella anisum Linn.
2 Atis Nepali Aconitum napellus Linn. Rhizome Aconitum chasmanthum Stapf
3 Bankhor, Pangar Aesculus indica Colebr. Seeds Entada pursaetha DC.
4 Dad Mari, Kurand ghas Ammannia baccifera Linn. Whole plant Corchorus depressus (L.) C. Chr.
syn. C. antichorus Raeusch.
5 Malaria plant, Sweet annie. Artemisia annua Linn. Whole plant Artemisia nilagirica (C.B. Clarke) Pamp.
6 Artemisia moorcroftiana Wall. Whole plant Artemisia brevifolia Wall. ex DC.
7 Shatawar Asparagus racemosus Willd. Root Asparagus sarmentosus Linn.
Asparagus adscendens Roxb.
Asparagus gonocladus Baker
Asparagus curillus Wall.
8 Neem Azadirachta indica A. Juss. Leaves Melia azedarach Linn.
9 Pot Marigold Calendula officinalis Linn. Whole plant Tagetes errecta Linn.
Cosmos bipinnatus Cav.
10 Kusum Carthamus tinctorius Linn. Whole plant Verbesina encelioides(C.)Benth. & H. ex A.
11 Tarwar Cassia auriculata Linn. Flowers Peltophorum pterocarpum Back. ex K. H.
12 Pawad Cassia tora Linn. Flowers Senna montana (B. Heyne ex Roth) V. Singh,
syn. Cassia montana B. Heyne ex Roth.
13 Brahma-manduki Centella asiatica (L.) Urban Whole plant Merremia emarginata (Burm.f.) Hallier f.
syn. Merremia gangetica (L.) Cufo
14 Kasni Cichorium intybus Linn. Roots Stem of Cichorium intybus Linn.
15 Dalchini Cinnamomum zeylanicum Breyn. Bark Cinnamomum impressinervium Miessn.
Cinnamomum cassia Blume
Cinnamomum tamala Nees & Eberm.
16 Crysopogon aciculatus (Retz.) Trin. Whole plant Heteropogon contortus (L.) Beauv.
syn. Andropogon contortus Linn.
17 Kachur Curcuma zedoaria Rosc. Rhizome Hedychium spicatum Buch. –Ham.
18 Akasbel Cuscuta reflexa Roxb. Whole plant Cuscuta chinensis Lamk.
Cuscuta hyalina Heyne ex Roth.
Mollugo cerviana (L.) Seringe
19 Dhub, Hariali Cynodon dactylon Pers. Whole plant Poa annua Linn.
20 Dioscorea villosa Linn. Root/Rhizome Dioscorea deltoidea Wall.
21 Kulthi Dolichos biflorus Linn. Seeds Macrotyloma uniflorum (Lamk.) Verdc.
syn. Dolichos uniflorum Lam.
22 Vai-Vidang Embelia ribes Linn. Fruits Embelia tsjeriam
–cottam ( Roems & Schult.) A. DC.
23 Field Horse Tail Equisetum arvense Linn. Whole plant Equisetum diffusum D. Don
24 Dudhi Euphorbia hirta Linn. Whole plant Enicostimma hyssopifolium (Willd.) V.
syn. E. littorale Blume
25 Saunf Foeniculum vulgare Mill. Roots Stem of Foeniculum vulgare Mill.
26 Kavitha, Kaith Feronia elephantum Correa Fruits Hydnocarpus alpina Wight
27 Pitpara Fumaria officinaslis Linn. Whole plants Fumaria vaillantii Loisel.
syn. F. indica Pugsley
28 Yellow Gentian Gentiana lutea Linn. Whole plant Valeriana officinalis Linn.
29 Anantmool Hemidesmus indicus R.Br. Roots Decalepis hamiltonii Wight. & Arn.
30 Bassant, Balsana Hypericum perforatum Linn. Whole plant Hypericum dyeri Rehder
Hypericum oblongifolium Choisy
Syn.H. cernuum Roxb.
H. elodeoides Choisy
H.oblongifolium Choisy
Reinwardtia indica Dun.
Table 3 :
Samples received by Trade/English name(s), identified incorrect
Sl no. Sample received Expected vide literature Part Sample identified as
1 Al Morinda citrifolia Linn. Leaves Morus alba Linn.
2 Anjubar Polygonum bistorta Linn. Whole plant Bistorta vivipara (L.) Delarbre
syn. Polygonum viviparum Linn.
3 Anantamul Amaranthus caudatus Linn. Root Ichnocarpus frutescens R.Br.
Hemidesmus indicus R.Br.
Tylophora indica (Burm.f) Merrill.
Syn. T. asthamatica Wight. & Arn.
4 Asaroon Asaram europaeum Linn. Root Valeriana jatamansi Jones
5 Ashoka Saraca asoca (Roxb.) de Wide. Bark Polyalthea longifolia Thw.
Syn. S. indica auct. non Linn.
6 Babuna Corchorus depressus (L.) C. Chr. Whole plant Brassica compestris Hook.f. & Thoms.
Cotula anthemoides Linn.
Matricaria chamomilla Linn.
7 Bala Abutilon indicum (L.) Sweet Whole plant Malvastrum coromandelianum Garcke
Amomum subulatum Roxb. Siegesbeckia orientalis L.
Barleria strigosa Wall.
Hibiscus tiliaceus L.
Paederia foetida L.
Pavonia odorata Willd.
Pavonia zeylanica (L.) Cav.
Observations and discussions The seed samples received in the name of Aesculus indica Colebr,
Out of 3486 crude drug samples, received for identification, 401 have been identified as seeds of Entada pursaetha DC., which have
samples have been identified either as their allied species or mixture been reported poisonous and produce toxic symptoms like
of the two or even altogether different plants belong to different vomiting and drowsiness if consumed raw ( Chopra et al, 1958).
families as given in table II and III. However, the samples of Piper
longum Linn., Cichorium intybus Linn. , Foeniculum vulgare Mill., The samples received as bark of Cinnamomum zeylanicum
received as roots, have been found as shoots/stem of these plants. Breyn. have been identified the bark of its allied species like
The samples received as fruits of Punica granatum Linn. and Tamarix Cinnamomum impressinervium Miessn., Cinnamomum cassia
gallica auct non Linn. have been identified as rinds of the fruits of Blume, Cinnamomum tamala Nees & Eberm. , where as the bark
Punica granatum Linn. and insect galls of Tamarix gallica auct non sample received as Salix alba Linn. was identified the bark of
Linn. respectively. Out of the nine samples received in the name of Valeriana pyrolaefolia Decne, which is altogether a different plant
Hypericum perforatum Linn., only one sample was found genuine from a different family. The samples received as whole plants of
Hypericum perforatum Linn., where as seven other samples have Carthamus tinctorius Linn., have been identified as Verbesina
been identified as its allied species like Hypericum dyeri Rehder, enceloides (Cav.) Benth. & Hook., which is reported a potential
Hypericum oblongifolium Choisy, H. elodeoides Choisy, H. hazard for grazing livestock and has been responsible for livestock
oblongifolium Choisy , and one sample was of Reinwardtia indica deaths in the U.S.A.
Dun., altogether a different plant belonging to the family Linaceae. It
www.ncbi.nlm.nih.gov/pubmed/1573558
is interesting to note that none of these allied species has reported
to contain hypericine, the active constituent present in Hypericum
The samples received as Anjubar, have been identified as
perforatum Linn., (Singh, 1999). Some of the samples received in the
Bistorta vivipara (L.) Delarbre, instead of the genuine drug
name of Asparagus recemosus Willd. have been identified as roots of
Polygonum bistorta Linn. The plant Bistorta vivipara (L.) Delarbre is
its allied species like Asparagus sarmentosus Linn., Asparagus
reported to aggravate the conditions of rheumatism, arthritis, gout,
adscendens Roxb., Asparagus gonocladus Baker, and Asparagus
kidney stones or hyperacidity if consumed by the people who are
curillus Wall. One sample received as roots of Aconitum napellus
suffering from these diseases
Linn. has been identified as Aconitum chasmanthum Stapf, which is
www.pfaf.org/index.php)
highly toxic and the skin become numbness while simply contact
with it.
www.pfaf.org/database/plants.php?Aconitum+chasmanthum The samples received as Brahami, supposed to be the samples of
either Bacopa monnieri (L.) Wettst. or Centella asiatiaca (L.) Urban
A sample received as leaves of Azadirachta indica A. Juss., has vide literature but the samples have been identified as Malva pusilla
been identified as leaves of Melia azedarach Linn. Though, the - Sm. (Mehta et al. 1991) and Merremia emarginata (Burm.f.) Hallier
leaves of Melia azedarach Linn have also been used similarly as f.. The drug Brahami, either Bacopa monnieri (L.) Wettst or Centella
natural insecticide like the leaves of Azadirachta indica A. Juss to asiatiaca (L.) Urban, said to be used to improve intellect, however,
keep with stored food. But due to presence of a poisonous the plants Malva pusilla - Sm. and Merremia emarginata (Burm.f.)
compound Tetranortriterpene neurotoxins in the leaves of Melia Hallier f.. have not been reported to possesses this property, instead
azedarach Linn., on consumption, shown deleterious effect on the plants Malva pusilla - Sm , when grown on nitrogen rich soils,
human health like stomach irritation, vomiting, bloody diarrhoea, tend to concentrate high levels of nitrates in their leaves, may cause
paralysis, irregular breathing, and respiratory distress. deleterious effect on human health
www.ces.ncsu.edu/depts/hort/consumer/poison/Meliaaz.htm www.pfaf.org/database/plants.php?Malva+pusilla