ANTI FUNGAL

REVIEW
MYCOSIS ?
SUPERFICIAL MYCOSIS

SYSTEMIC MYCOSIS
 CLASSIFICATION
• DRUGS FOR SYSTEMIC MYCOSIS

Amphotericin B
AZOLES
Fluconazole
Itraconazole
ketoconazole
Flucytosine
DRUGS FOR MUCOCUTANOUES MYCOSIS

GRISEOFULVIN

TERBINAFINE
DRUGS FOR SUPERFICIAL MYCOSIS

Nystatin

Clotrimazole

Miconazole

Econazole
 SUPERFICIAL MYCOSES

Dermatophyte infections
• Ring worms
• tinea

Candida infections
•Cutaneous
•Moucosa Alimetary tract.
• vaginal
 Superficial mycoses
Infection Drugs Route
Imidazoles Topical
Ring worm Clotrimazole Topical
Econazole Topical
Tinea
Miconazole Topical
Sulconazole Topical
 Candida Infections
amphotericin Topical
Clotrimazole Topical
Econazole Topical
Cutaneous
Miconazole Topical
Nystatin Topical
 Candida Infections
amphotericin IV
Mucosa Fluconazole Orally / IV
Alimentary ketoconazole Only Orally
tract
Miconazole Lozenges / Gel /
Nystatin Suspension or
tablets
 Candida Infections
Clotrimazole
Econazole
Isoconazole Pessaries
Vaginal
ketoconazole Vaginal tablets
Miconazole cream
Nystatin
 Systemic mycosis

Aspergillosis
Candidiasis
Coccidiodoidomycosis
Cryptococcosis
Histoplasmosis
Sporotrichosis
 Classification of anti fungal drugs
according to
Mechanism of action

Drugs that disrupt the cell membrane

Drugs that inhibit mitosis

 Drugs that disrupt cell membranes

• Polyene antibiotics

•Amphotericin B
•Nystatin
 AZOLES
Imidazoles Ketoconazole
Miconazole
Clotrimazole
Isoconazole
Ticonazole

Triazoles Fluconazole
Itraconazole
 Mechanism of action
• Polyene antibiotics

Binds to sterols (ergo sterol) present

in the cell Membranes Leakage
of intracellular ions & enzymes
Cell death
 Azoles
• Imidazoles (KIMC)
Interfere with fungal oxidative
enzymes Lethal accumulation of
hydrogen peroxide

Triazoles (FI)

Inhibit demethylase enzyme

damage cell membrane
 Drugs that inhibit Mitosis

• Griseofulvin
• Flucytosine

Flutycosine 5 flurouracil

Inhibit nucleic acid synthesis