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PATHOPHYSIOLOGY OF INFARCTION

ACUTE MYOCARDIAL INFARCTION


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MODIFIABLE FACTORS: Hypertension Smoking levels of triglyceride, total cholesterol & LDL DM Obesity Excessive intake of saturated fats, carbohydrates or salt Sedentary lifestyle/physical inactivity Stress/Type A personality Drug Abuse

NONMODIFIABLE FACTORS: (+) Family Hx of AMI Aging Men and Postmenopausal Women

Change in the Condition of Plaque in the Coronary Artery

Rest Pain

Activation of Platelets Platelet Aggregation, Adhesion, & Buildup of Platelet Mass

Claudication ATHEROSCLEROSIS N/V THROMBOSIS

Release of Thromboplastin

Fainting

Platelet release Thromboxane A2, Serotonin, Platelet Factors 3 & 4

Sweating Coagulation and Vasospasm Cool extremities

Enlargement of Thrombus

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