Chapter 2 Review Question Answers 1.

Excretion, particularly if water soluble Rapidly metabolized Rapidly partitioned into tissue depots Conjugate acid: !e product of a base plus water Conjugate base: !e product of an acid plus water #$ at p% ".& #1$ at p% '.& (it! a p)a of *.+" and a p!ysiological p% of *.', selegiline would be approximately +,$ in t!e ionized form. !erefore, it would be more soluble at p% &.+ and less soluble at p% -.+. ./0R C033 Co560 Co5/70 8og 9 8og 3 % / -. *. 1uantitati2e structure acti2ity relations!ip computer4aided drug design comparati2e molecular field analysis comparati2e molecular similarity indices analysis partition coefficient usually in octanol:water systems distribution coefficient in an octanol:water system t!at ta;es into account t!at a percentage of t!e molecule may be in t!e ionized state !ig!4t!roug!put screening

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2an der (aals, dipole:dipole, !ydrogen, ionic, co2alent 8ipins;si Rule of 6i2e is a set of rules t!at defines drug li;eness and is used w!en searc!ing a c!emical database to screen out compounds t!at would be poor candidates for de2elopment.

C!. 2 Re2iew .uestion 0nswers