Biology 10/29/2013 5:09:00 AM

Signals relay between cells

1. Direct intercellular signaling- local
2. Contact signaling- local
3. Autocrine signaling- local
4. Paracrine signaling- local
5. Endocrine signaling- long distance

Three stage of cell signaling
1. Receptor activation
2. Transduction
3. Cell Response

Ligand signaling molecule
o Small
o Binds non-covalently specific receptors
o Binging and release between receptor and ligand relatively rapid
o Ligand trigger receptor structure-conformational change
o Ligand-receptor complex is activated initiates a cellular response

Cell surface receptors
Enzyme-linked receptors
G-protein coupled receptors (GPCR)
Ligand-gate ion channels

G-proteins bind to GTP or GDP




10/29/2013 5:09:00 AM

10/29/2013 5:09:00 AM