The cell cycle-specific agent vincristine sulphate (Oncovin) acts in which phase of the cell's life cycle? 44-2 D G 0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.
The cell cycle-specific agent vincristine sulphate (Oncovin) acts in which phase of the cell's life cycle? 44-2 D G 0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.
The cell cycle-specific agent vincristine sulphate (Oncovin) acts in which phase of the cell's life cycle? 44-2 D G 0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc.
Clayton: Basic Pharmacology for Nurses, 15
th Edition
Chapter 44: Drugs Used for Cancer Treatment
Test Bank
MULTIPLE CHOICE
1. The nurse is educating a patient with cancer about combination chemotherapy. Which is an accurate statement? A. Combination chemotherapy is the administration of an antineoplastic drug that will be toxic during a specific phase of cellular growth. B. Combination chemotherapy is the administration of an antineoplastic drug that is active throughout the cell cycle. C. Combination chemotherapy is the administration of antineoplastic drugs that change the way the body responds to cancer or strengthens the immune system. D. Combination chemotherapy is the administration of antineoplastic drugs, which results in cell death during different phases of the cell cycle.
ANS: D
Feedback A This is a single drug regimen, not a combination. B This is a single drug regimen, not a combination. C This is a single drug regimen, not a combination. D Use of combination drug therapy is superior in therapeutic effect to the use of single-agent chemotherapy.
2. The cell cyclespecific agent vincristine sulphate (Oncovin) acts in which phase of the cells life cycle? A. S phase B. Mitotic phase C. Phase G 1
D. Phase G 0
ANS: B
Feedback A The S phase is the stage of active synthesis of two sets of DNA. B Vinca alkaloids block the formation of the mitotic spindle during mitosis, thus inhibiting cell division. C Phase G 1 is considered a presynthetic phase in which the cell prepares for DNA synthesis by manufacturing necessary enzymes. Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-2 D G 0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.
3. What is the importance of correlating the dosage schedule with cell cyclespecific drug therapy? A. Ongoing proliferation of neoplastic tissue B. The known cellular kinetics of the neoplasm C. The hormonal requirements of the patient D. The bodys response in strengthening the immune system
ANS: B
Feedback A The object of chemotherapy is to stop the proliferation of neoplastic tissue. B Cell cyclespecific agent scheduling should be correlated with the known cellular kinetics of the particular type of neoplasm being treated. This type of drug is schedule-dependent and selectively toxic when the cell is in a specific phase of growth. C Hormones are only used in specific types of cancer and are not related to cell cycle specificity. D Immunomodulators are used to enhance the bodys response in strengthening the immune system.
4. When are cancer cells most sensitive to chemotherapy? A. Resting phases B. Rapid division C. Remission intervals D. Slow replication
ANS: B
Feedback A Cancer cells are not sensitive to chemotherapy during resting phases. B The cancer cells are the most sensitive to chemotherapy when the cells are dividing rapidly. C Cancer cells are not sensitive to chemotherapy during remission intervals. D Cancer cells are not sensitive to chemotherapy during slow replication.
DIF: Cognitive Level: Knowledge REF: 697 Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-3 TOP: Nursing Process Step: Implementation MSC: NCLEX Client Needs Category: Physiological Integrity
5. What is the advantage of combination therapy using cell cyclespecific and cell cycle nonspecific agents? A. Decreased expense and time needed for administration B. Decreased toxicity to patients and the nurses who administer the drug C. Increased cell death in various cycles and decreased toxicity D. Increased rate of treatment success
ANS: D
Feedback A Combination therapy is not more economical or faster. B Combination therapy is not less toxic because it exposes patients and nurses to additional medications. C The use of combination drug therapy allows for cell death during different phases of the cell cycle, but the agents often have toxic effects on different organs at different time intervals after administration. D Combination therapy is far superior to the use of single-agent therapy. The use of a cell cyclespecific and cell cyclenonspecific agent together facilitates cell death during different phases of the cell cycle.
6. Why is a patient with prostate cancer prescribed an estrogen? A. To achieve hormonal balance B. To decrease the rate of production for malignant cells C. To soften prostatic tissue D. To suppress prostate gland function
ANS: B
Feedback A Estrogen is not given for hormonal balance. B Estrogen therapy is used during the treatment of prostate cancer to decrease the rate of production of malignant cells. The use of female hormones decreases the amount of male hormones available for use by the cancer cells. C Estrogen does not soften prostatic tissue. D Estrogen does not suppress prostate gland function.
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-4 7. Which assessment by the nurse would be a sign of neurotoxicity related to chemotherapy? A. Paresthesia B. Euphoria C. Nausea D. Hallucinations
ANS: A
Feedback A Signs and symptoms of neurotoxicity include numbness and tingling in extremities, confusion, changes in gait, and motor weakness. B Euphoria is not a sign of neurotoxicity related to chemotherapy. C Nausea is not a sign of neurotoxicity related to chemotherapy. D Hallucinations are not a sign of neurotoxicity related to chemotherapy.
8. Which symptom is the patient who is receiving bleomycin (Blenoxane) therapy most likely to exhibit? A. Increased respiratory rate and cough B. Weight gain and peripheral edema C. Numbness and tingling of hands and feet D. Lethargy and orthostatic hypotension
ANS: A
Feedback A Compromised respiratory function may occur in patients receiving bleomycin therapy. Increased respiratory rate and cough can be signs that further problems are developing, such as heart failure. B Bleomycin does not cause weight gain and peripheral edema. C Bleomycin does not produce numbness and tingling of hands and feet. D Bleomycin does not produce lethargy and orthostatic hypotension.
9. What is the purpose of administering filgrastim (Neupogen) to a patient who is post bowel resection secondary to cancer? A. Decrease the gastrointestinal toxicity secondary to chemotherapeutic agents B. Suppress the immune response C. Work as an antiemetic and stimulate his appetite D. Increase the white blood cell counts Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-5
ANS: D
Feedback A Filgrastim does not affect GI toxicity. B Filgrastim does not suppress immune response; it works to enhance it. C Filgrastim does not affect appetite or nausea. D Filgrastim works to stimulate white blood cell production and decrease the incidence of infection. Filgrastim is a colony-stimulating factor, which stimulates white blood cell proliferation and maturation. It is particularly helpful for patients prone to neutropenia secondary to cancer therapy.
DIF: Cognitive Level: Application REF: 700 TOP: Nursing Process Step: Implementation MSC: NCLEX Client Needs Category: Health Promotion and Maintenance
10. What is the intended outcome of the chemoprotective drug amifostine (Ethyol)? A. Decreased nausea and vomiting B. Increased effectiveness of the chemotherapy C. Maintenance of body weight D. Decreased renal toxicity
ANS: D
Feedback A Chemoprotective drugs do not decrease nausea and vomiting. B Chemoprotective drugs do not enhance the effectiveness of chemotherapy treatment. C Chemoprotective drugs do not help prevent weight loss. D Amifostine is used to reduce the cumulative renal toxicity associated with the repeated administration of cisplatin in patients with advanced ovarian cancer.
11. Why are bone marrow stimulants used in the treatment of cancer? A. To increase uptake of the chemotherapy from the interior of the bones B. To strengthen bones weakened by pathologic processes C. To enhance the patients immune system during treatment D. To protect the bone marrow from destructive actions from the cancer treatment
ANS: C
Feedback A Bone marrow stimulants do not increase uptake of drugs. B Bone marrow stimulants do not strengthen bones. Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-6 C Bone marrow stimulants trigger the recovery of bone marrow cells several days earlier than would be the natural course of recovery. The major benefit to this earlier recovery is that patients immune systems are able to respond to and stop infections from being so pathologic, and patients can be released from the isolation room several days earlier. D Bone marrow stimulants do not protect the bone marrow from destructive effects of chemotherapy or radiation.
12. The nurse is providing education about chemotherapy to a patient who is being discharged. Which statement by the patient indicates a need for further teaching? A. I will shave with an electric razor. B. I will take aspirin for a headache. C. I will wash my laundry separate from other family members. D. I will flush the toilet twice after using.
ANS: B
Feedback A Shaving with an electric razor is preferable for a patient undergoing chemotherapy because of the decreased risk of bleeding. B Patients should not take any aspirin or aspirin-containing products. C The clothing of the chemotherapy patient should be washed separately from other household linens. D Because most chemotherapeutic agents are excreted in the urine and feces, it is best to flush the toilet two or three times.
1. Which are major chemotherapeutic agents? (Select all that apply.) A. Alkylating agents B. Antineoplastic antibiotics C. Hormones D. Antimetabolites E. Antinuclear antibodies F. Chelating agents
ANS: A, B, C, D
Feedback Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-7 Correct Alkylating agents are considered major chemotherapeutic agents. Antineoplastic antibiotics are considered major chemotherapeutic agents. Hormones are considered major chemotherapeutic agents. Antimetabolites are considered major chemotherapeutic agents. Incorrect Antinuclear antibodies are antibodies produced by the immune system that attack the body's own tissues instead of foreign toxins. They are frequently present in people with systemic lupus erythematosus and, less commonly, in other diseases. Chelating agents are used to detoxify a patient from heavy metal poisoning.
2. Which nursing considerations are taken into account prior to the administration of cisplatin IV? (Select all that apply.) A. Review of laboratory data for presence of myelosuppression and hepatic and renal parameters B. Administration of IV hydration as prescribed C. Administration of epoetin alpha (Epogen) D. Administration of prechemotherapy mesna (Mesnex) E. Assessment for dermatologic conditions
ANS: A, B, D
Feedback Correct Premedication nursing considerations regarding cisplatin, an alkylating agent, include checking laboratory reports for baseline data reflecting hepatic and renal function and baseline hematologic studies that reflect the degree of myelosuppression present before initiating chemotherapy. Premedication nursing considerations regarding cisplatin, an alkylating agent, include assessing patient hydration and the health care providers orders for oral and IV hydration instructions before drug therapy. Premedication nursing considerations regarding cisplatin, an alkylating agent, include administering prechemotherapy drugs including mesna, ondansetron, and antianxiety drugs. Incorrect Epogen is given to treat anemia associated with chemotherapy; it is not given before administration of chemotherapy. Dermatologic assessment is not necessary before administering cisplatin.
3. Which signs and symptoms assessed by the nurse are indicative of thrombocytopenia? (Select all that apply.) Test Bank
Mosby items and derived items 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. 44-8 A. Pinpoint red rash B. Casts in urine C. Brown, fatty stools D. Increase in menstrual flow E. Coffee ground emesis
ANS: A, D, E
Feedback Correct Pinpoint red rash indicates thrombocytopenia, which causes an increased tendency to bleed. An increase in menstrual flow indicates thrombocytopenia, which causes an increased tendency to bleed. Coffee ground emesis indicates thrombocytopenia, which causes an increased tendency to bleed. Incorrect Thrombocytopenia may cause hematuria. Thrombocytopenia may cause dark, tarry stools.
DIF: Cognitive Level: Application REF: 704 TOP: Nursing Process Step: Assessment MSC: NCLEX Client Needs Category: Health Promotion and Maintenance
4. Which are treatments that may be used alone or in combination for the treatment of cancer? (Select all that apply.) A. Surgery B. Radiation C. Chemotherapy D. Immunotherapy E. Phlebotomy
ANS: A, B, C, D
Feedback Correct Treatment of cancer often requires surgery. Treatment of cancer often requires radiation. Treatment of cancer often requires chemotherapy. Treatment of cancer often requires immunotherapy. Incorrect Phlebotomy does not treat cancer cells.