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1) Definition

2) Role Of Inflammation In Health &


Disease
3) Stimuli For Acute Inflammation
4) The mechanism of acute inflammation
Generally, Inflammation is the reaction of
the vascularized connective tissue in response
to the injury or stimuli
Acute Inflammation >> rapid host
response (minutes/hours/days) that
serves to deliver leukocytes & plasma
protein (antibodies) >> site of injury
1) INFECTIONS
- Bacterial/Virus/Fungal/Parasitic >>
inflammation

2) TISSUE NECROSIS
- From any cause
(eg.ischemia/trauma/physical/chemical
injury)
3) FOREIGN BODIES
- (Splinters,dirts,sutures) >> inflammation

4) IMMUNE REACTIONS (HYPERSENSITIVITY)
- Normal protective immune system
damages individuals tissue >>
autoimmune disease
2 Events :

1) Vascular Event
- Change In vascular flow & caliber
- Extravasation of plasma fluid & protein

2) Cellular Event
- Leukocyte immigration & phagocytosis


i. Margination
ii. Rolling
iii. Activation
iv. Adhesion
v. Migration
vi. Diapedesis (Transmigration)
vii. Chemotaxis & Phagocytosis
Distinguishing the morphological types of
acute inflammation
Recognize the morphological changes
at tissue and cellular level
Outpouring of watery, relatively protein-
poor fluid depending onsite of injury
(from plasma or mesothelial lining )
Skin blister ; from burn or viral infection
Fluid in serous cavity is called effusion

SEROUS
INFLAMMATION
SEROUS
EFFUSION
More severe injury
Result in greater vascular permeability
that allows larger molecules (eg;
fibrinogen) to pass through endothelial
barrier
the accumulated extravascular fibrin
appears as an eosinophilic meshwork of
threads or sometimes as an amorphous
coagulum
Large collection of purulent exudate
(pus)- neutrophils, necrotic cells, edema
fluid
Localized suppuration;
Pyogenic microorganism ;
staphylococci
Abscesses are focal collections of pus
that may be caused by seeding of
pyogenic organisms into a tissue or by
secondary infections of necrotic foci

local defect, or excavation, of the
surface of an organ or tissue that is
produced by necrosis of cells and
sloughing (shedding) of necrotic and
inflammatory tissue

OR
Definition: any
messenger that
acts on blood
vessels,
inflammatory cells
or other cells to
contribute to an
inflammatory
response
WHERE DOES THE MEDIATORS
CAME FROM?