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Is the infection of the large intestine by the

protozoan parasite Entamoeba Histolytica with or


without clinical manifestations.

Transmitted in areas where poor sanitation allows


contamination of drinking water and food with
feces
Person to person through the fecal-oral ingestion of
cysts
Men who have sex with men
Use of human feces (night soil) for soil fertilizer
Contamination of foodstuffs by flies, and possibly
cockroaches

Cysts and trophozoites


are passed in feces
Infection occurs by
ingestion of mature
cysts
Excystation occurs in
small intestine and
trophozoites are
released , which
migrate to the large
intestine

1- secreting proteolytic
enzymes( histolysine )
and cytotoxic
substances.

2 - contactdependent cell
killing
3 cytophagocytosis

Asymptomatic

Symptomatic infection

Intestinal amebiasis
Dysentery

Ekstraintestinal amebiasis

Non-dysenteric colitis
Hepatic

Pulmonary Brain

Liver abscess Acut nonsupprative

Mild symptoms :
- Abdominal cramps
- Diarrhea
(Passage of 3-8 semiformed stools per day)
(Passage of soft stools with mucus and
occasional blood)
- Fatigue
- Flatulance
- Rectal pain while having a tenesmus
- Unintentional weight loss

Severe symptoms
- Abdominal tenderness
- Bloody stools
(Passage of liquid stools with
streaks of blood)
(Passage of 10-20 stools per day)
- Fever
- Vomitting

Microscopic examination of protozoan morphology


Antibody detection
Can be detected in 75-85% of patient with
symptomatic E.Histolytica infection
Serology test

Metronidazole by oral 500-750mg tid 5-10


days. This is followed by paromomycin
25-35mg/kg tid 7-10 days
Medicines to stop the diarrhea are
ussually not prescribed because they
can make the condition worse