~EUROMED *: St. John’s Wort Extract Description EUROMED St. John's wort extract i @ standardized herbal ‘extract of Hypericum perforatum L herb, aleaty plant native to all of Europe, west Asa, the Canary Islands and North Arca Chemistry ‘i John's wort contains several groups of substances, identified fend quantified according te modern scientific anclytical methods. The naohthodianthrones hypericin and pseudo- hypericin are characteristic substances of pharmacoiogical interest. Other important constituents ave flavonelds hyperforins along with essential ai, carotenoids, and preanthocyaniins Indications Extracts of St. John's wort are used in depressive states and paychovegetative disorders as well as anxiety andior nervous ‘agitation. thas a mood-enhancing and drve-improving effect ‘95 well as relieving both anxiety and tension; the capacity for ‘enjoying if is increased. Itdoes not cause tiredness or affect responses because it does not interact with ether drugs. Its suitable fer patients ofall ‘age groups os well as for patients with multiple diagnoses. Contraindications, interactions and side-effects Si. John's wort extract is generally wel tolerated. Side-effects ‘are rare when the standardized extracts taken, In exceptional ‘cases gastro-intestinal irrtations and photosensitization in fair-skinned people may occur. It does not have a sedative effect and can be recommended without restrictions fer patients who are working and require full concentration for driving and fer operating machines. It is not addictive and its effect Is not increased by alcohol Therapeutic Safety St. John's wort extracts notable frit particulary high level of clinical safety. To-date acute cases of St. John's wort extract Poisoning have nat been reportedEUROMED > Analytical Specifications Denomination ST. JOHN'S WORT DRY EXTRACT Used plant drug 3 Hypericum perforatum Used plant parts 5. Herb with flower Powder, greyish brown colour, aromatic edour slightly biter taste me Max. 5.0% ‘Total hypercins expressed as hypercin min. 0.3% (DAC-1986, 3rd comp. 1991)-Total hypericins expressed as hypericn min. 0.15-0.25% (HPLC). Hyperforin1.0-4.0% (HPLC). Flavonoids min. 4.0% (HPLC) > Ace. Ph. Eur ed, 5:14, cat. 98 > Selected References > SCOP Menogronh Hyer hea . dar wort open Sent Cooperate on Phtheapy ou 1936) 2 > ages Handbuch er Drogen snd Zor _Arzneistotte Springer-Verlag Berlin Heidelberg 08) 0.09 > Hypericum extract: for the use in depression ty cuRONED ie > wo turomeder e oheratmec tvitan