TABLE 3 Classification and Bnet Desorption of Main ‘Theories of Aging ‘Biological level! theory Deseription Moiecutar ‘Codon restriction Fidelity andor accuracy of mANA message ‘ransiaton is mpased wan agng due 10 cel inability to decode the tipie codons (bases) in mRNA molecules Somatc mutation Type of stochastic theory of aging that assumes “fat an acoumulston of ewonmental insu -evertusly races a level mcompathia wih ite, prmaniy because of genete damage Error catastrophe Errors in mtommation wanster due 1 alterations in AINA polymerase and tRNA ayniheiase may Jncesse wih age, resuting in ncessed production of abnoma! protans Gene regulation Aging is caused by changes in the expression of "genes reguiaiing both development and aging Dysdifferentiatos Gradual accumulaton of rancom molecular ‘samage impairs reguiaten of gene expression Cetiar ‘Wear anditear —ntrinsic and exirinsie factors influence Me span Fiee rachcal ‘Credative metsbatiam produces thee radicals that ‘accumulation ‘af highly reactne and thus damage DNA snd ‘or proteins and thus degrade the system structure nd function Apoptosis Process of systematcally diamanting key cellular ‘components 2s fhe outcome of a programmed tracellular cascade of genetically determined steps, System Riste-of-wing An old theory that assumes that theres a certain number of csiories.or heart bests alloted to an ingividual and the faster these are used, the shorter he ide Neuroendocrine Alterations in either the number or the sensitvily ‘of venous neuroendocrine reception give tse 19 homeostatic or homeodynamic changes that ‘esuit in senescence Immunologe Immune system reduces «5 delenses against ‘antgens, resulting in an inceasing incidence of infectons and autommune diseases: Evolutionary Antagonstic ‘Alleles that have beneficial effects on fiiness at pleictropy ‘young.ages can also have Geletenous elects on ‘iiness ister mile Mutation ‘The foros of natural ssiection declines at older ‘accumulaton ages 10 @ point where & has litle impact on (Disposable soma Preferential allocation af energy resources for reproduction to the deinment of maintenance and suraval of somane oes