Menstrual Masterx

Clinical Applications

Menstrual Masterx provides the conditionally essential omega-3 fatty acids EPA (eicosapentaenoic) and DHA
(docosahexaenoic) from Antarctic krill (Euphausia superba); phospholipids (80% as phosphatidylcholine);
and the carotenoid astaxanthin, which provides antioxidant support and has a characteristic red color.

Distributed By PPM Pharmacy

3300 NW 56th St. Suite 101
Oklahoma City, OK 73112

Provides a Highly Absorbable, Phospholipid Form of Omega-3 EPA and DHA

Helps Promote a Healthy Cytokine Balance in the Body*
Helps Maintain a Healthy Omega-3 Index*
Supports Healthy Cell Membrane Fluidity*
Supports Normal Blood Lipid Metabolism*
Supports Cardiovascular Health*
Supports a Healthy, Comfortable Response to Menstrual Cycle Fluctuations*

All Star Nutraceuticals Formulas Meet or Exceed cGMP Quality Standards

Discussion
Menstrual Masterx, also known as Onemia, is a patented formulation designed to support normal blood lipid metabolism, support antioxidant mechanisms,
and promote a healthy cytokine balance in the body. These effects, in turn, support cardiometabolic health.*
Omega-3 Fatty Acids Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)conditionally essential omega-3 fatty acidshave been extensively
studied for their positive effects on cardiovascular health, cognitive integrity, immune function, and the bodys production of arachidonic acid-derived
eicosanoids.[1,2] Research suggests that serum levels of EPA and DHA are inversely associated with cardiovascular health,[3,4] while the omega-3 index (a
measurement of EPA and DHA in erythrocyte membranes) has become recognized as a biomarker of cardiovascular health.[4] Clinical trials suggest that
Menstrual Masterx promotes an improvement in omega-3 index scores.[5] Menstrual Masterx provides EPA and DHA from krill in concentrated, bioavailable,
phospholipid forms that were found to have a greater impact on blood lipid metabolism and promote an increase in omega-3 index scores more profoundly
and more quickly than fish oil.*[5,6]

Antarctic Krill (Euphausia superba) Krill, a coldwater marine crustacean, is a rich source of omega-3 EPA and DHA. Krill oil has been used in several
human clinical trials, and research consistently suggests that it supports antioxidant activity, healthy cell membranes, cardiovascular health, and positively
influences the production of arachidonic acid-derived eicosanoids.[8-10] Krill is considered to be stable and relatively resistant to oxidation, unlike other sources
of polyunsaturated fatty acids (PUFAs). Krills stability is attributed to its antioxidant content, including vitamin E and astaxanthin.[9] Krill is low on the food chain
and its harvesting and sustainability is monitored.[11]
Astaxanthin As a red-orange member of the carotenoid family, astaxanthin participates in antioxidant activity. Both animal and clinical research suggest that
astaxanthin supports antioxidant mechanisms and helps promote a healthy cytokine balance in the body.[12] Krill is recognized as a rich source of astaxanthin
and a potentially valuable contributor to cardiovascular and cell membrane health.*[9]
Research A double-blind crossover trial compared uptake of EPA/DHA from krill (in phospholipid form) to uptake from two forms of fish oil (ethyl esters [EEs]
and re-esterified triacylglycerides [rTAGs]. Results suggested that krill oil had superior bioavailability and promoted the highest incorporation of EPA and DHA into
plasma phospholipids.[13] A multicenter, three-month, prospective, randomized, double-blind, placebo-controlled study compared the effects of krill oil versus
fish oil on blood lipid metabolism. Results suggested that krill oil, even at lower doses, had a more profound effect on maintaining normal blood lipid metabolism
than fish oil did.[6] The study used highly concentrated krill oil (Menstrual Masterxs main component) in doses of 1, 1.5, 2, or 3 g versus 3 g of fish oil. In the
same study, researchers also observed that krill oil supported blood glucose metabolism better than fish oil did.*
A randomized, double-blind, parallel-arm trial of 76 subjects indicated that 2 g/day of krill oil significantly increased plasma EPA and DHA levels and was welltolerated.[14] In six clinical trials, highly concentrated krill oil was administered to a total of 203 subjects at a dose of up to 6g/day with no serious side effects
observed.*[5]
Krill oil also appears to be superior to fish oil for supporting a healthy, comfortable response to menstrual cycle fluctuations. A prospective, randomized, doubleblind, three-month clinical trial of 70 women was conducted comparing 2 g of krill oil to 2 g of fish oil during menstrual cycle fluctuations. For subjects taking
krill oil, self-assessment questionnaire scores (based on the American College of Obstetricians and Gynecologists criteria) revealed a statistically significant
improvement in emotional and physical state from baseline. In addition, questionnaire scores were statistically significant between those taking krill oil and
those taking fish oil. There was also a significant reduction in the krill oil groups consumption of other treatments for menstrual cycle fluctuations.*[15]

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

Menstrual Masterx

Phospholipids Considered the building blocks of healthy cells, phospholipids help maintain cell membrane fluidity and function. The phospholipid form
(versus triglyceride form) of EPA and DHA is easily recognized, integrated, and utilized by the bodys cells. The major phospholipid in Menstrual Masterx is
phosphatidylcholine (PC), a phospholipid that is highly concentrated in the heart, brain, liver, and kidneys.*[7]

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30

Amount Per Serving %Daily Value

Calories
Calories from fat
Total Fat
Trans Fat

5
5
0.5 g
0g

Krill Oil
Marine Phospholipids
Total Omega-3 Fatty Acids
EPA (eicosapentaenoic acid)
DHA (docosahexaenoic acid)
Astaxanthin

1%

1g
540 mg
300 mg
155 mg
105 mg
2 mg

Directions
Take two capsules in the morning, preferably
after breakfast, or as recommended by
your
healthcare
practitioner.
Swallow
whole. Do not crush or chew capsules.
Consult your healthcare practitioner before use,
especially if you have coagulopathy or are taking
an anticoagulant. Do not use if the seal is broken or
missing.

**
**
**
**
**
**

Percent Daily Values are based on a 2,000 calorie diet.

** Daily Value not established.
Other Ingredients: Capsule (tilapia fish gelatin, titanium dioxide,
and water) and medium-chain triglycerides.
Contains: Shellfish (krill) and may contain traces of fish.

References
1. Linus Pauling Institute. http://lpi.oregonstate.edu/infocenter/othernuts/omega3fa/#metabolism. Accessed April 20, 2012.
2. GOED Omega-3. http://www.goedomega3.com/clinical-studies.html. Accessed April 20, 2012.
3. Pottala JV, Garg S, Cohen BE, et al. Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable
coronary heart disease: the Heart and Soul study. Circ Cardiovasc Qual Outcomes. 2010 Jul;3(4):406-12. [PMID: 20551373]
4. Harris WS. The omega-3 index as a risk factor for coronary heart disease. Am J Clin Nutr. 2008 Jun;87(6):1997S-2002S. [PMID: 18541601]
5. Onemia. http://onemia.com/professional/studies.php. Accessed May 8, 2012.
6. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev. 2004
Dec;9(4):420-8. [PMID: 15656713]
7. Phosphatidylcholine. Natural Standard Database. http://naturalstandard.com/databases/herbssupplements/phosphatidylcholine.asp.
Accessed April 16, 2012.
8. Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids. 2003 Nov;126(1):1-27.
Review. [PMID: 14580707]
9. Tou JC, Jaczynski J, Chen YC. Krill for human consumption: nutritional value and potential health benefits. Nutr Rev. 2007 Feb;65(2):63-77.
Review. [PMID: 17345959]
10. Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007 Feb;26(1):3948. [PMID: 17353582]
11. CCAMLR. http://www.ccamlr.org/en/fisheries/krill-fisheries. Accessed September 9, 2013.
12. Hussein G, Sankawa U, Goto et al. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. 2006 Mar;69(3):4439. Review. [PMID: 16562856]
13. Schuchardt JP, Schneider I, Meyer H, et al. Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3
fatty acid formulationsa comparative bioavailability study of fish oil vs. krill oil. Lipids Health Dis. 2011 Aug 22;10:145. [PMID: 21854650]
14. Maki KC, Reeves MS, Farmer M, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic
acids in overweight and obese men and women. Nutr Res. 2009 Sep;29(9):609-15. [PMID: 19854375]
15. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and
dysmenorrhea. Altern Med Rev. 2003 May;8(2):171-9. [PMID: 12777162]

Does Not Contain

Wheat, gluten, corn, yeast, soy, dairy products, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or
preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

Distributed By PPM Pharmacy

3300 NW 56th St. Suite 101
Oklahoma City, OK 73112

DRS-174
REV. 04/22/14