TheeffectofDMToncancercell

Introduction

Cancer:
Canceristhediseasethatcausedbyunstoppablecelldivision,withouttreatedcancer
canleadtoseriousillnessordeath.Moreover,therearemorethan100typesofcancerinthe
modernday,whichdifferentintheoriginofcancer,ratesofdivision,andtreatmentresponses.

http://www.cancer.org/cancer/cancerbasics/whatiscancer

Sigma1receptor:
Normally,cellapoptosiswillcontrolbythemitochondrial Ca2+ signaling,inwhich
mitochondriawillrespondtoit.However,thissignalisdeterminedbytheamountof Ca2+ in
cytosol,whichisregulatedbyIP3Rsreceptorintheendoplasmicreticulum.Iftheamountof
Ca2+ isoverload,itwillleadtotheapoptosisofthecell.Besides,IP3Rsreceptorhelpsto
maintainhomeostasisof Ca2+ ,providepropermitochondrial Ca2+ signalingtomitochondria,
andpreventcellapoptosis.Therefore,thisishappeninthemitochondriaassociatedER
membranes(MAM)withtheassistanceofERchaperones.

Sigma1ReceptorisakindofERchaperonesandanonopioidERprotein(opioid
receptor),whichcommonlyfoundinthecentralandperipheralnervoussystem.Itbindswith
benzomorphan,steroids,andpsychotropicdrugs(an
alkylaminecore)
.Moreover,itregulates
+
neuritogenesis, K channel,memory,drugaddiction,andalsoIP3Rsmediated Ca2+ signaling.
Hence,Sigma1receptorisoneoffactorsthatantiapoptoticaction.

http://cancerres.aacrjournals.org/content/64/14/4875.full.html
http://www.sciencedirect.com/science/article/pii/S0092867407010999
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712323/
http://www.ncbi.nlm.nih.gov/pubmed/24204710
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947205/

N,N
Dimethyltryptamine(DMT):
N,NDimethyltryptamineorDMTisahallucinogenicdrug,whichcanbetakenby
consumed,drinked,inhalationorsmoked.Itisusuallyfoundinmanytypesofplantsand
animals,butthemostcommononeisinarootofnativetreeinSouthAmericacalledMimosa
Hostilis.Therefore,italsobefoundinahumanbraininasmallamountaswellmoreover,its
functionisstillunknownandthetargetedreceptorstillunclear.However,D.Fontanilla,whois
theanalystofDatamonitorHealthcaresteam,recentlyhaveresearchonDMTwhichisan
endogenousagonistforthesigma1receptor.

http://www.datamonitorhealthcare.com/people/dominiquefontanilla/

https://drugsforum.com/forum/showwiki.php?title=DMT
http://www.wisegeek.org/whatisdmt.htm
http://deoxy.org/gz_howy.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947205/

WoundHealing:
Woundhealingprocessconsistsof4phaseshemostasis,Inflammation,Growthand
rebuilding,andStrengthening.
Hemostasisisaphrasethatbleedingbegins.Inthisphrase,theclottingwilloccur.
Inflammationisaphrasethatnutrientandoxygenwillaccessintothewoundforhealing.
Growthandrebuildingisaphrasethatwillbuildupthemissingpart.Moreover,
chemicalssignalswillbesendtostimulatedproducingofcollagen
Strengtheningisaphrasethattheywilltaketimetogetstronger.

http://www.hopkinsmedicine.org/healthlibrary/conditions/surgical_care/how_wounds_heal_134,1
43/
http://www.ncbi.nlm.nih.gov/pubmed/19930861
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857239/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495371/

http://biology.stackexchange.com/questions/2602/pipettingdamageoncells
http://www.biolink.org/home/sites/files/students_manualv7.pdf