Breast Cancer a Thing of

the Past: First Steps

Jose Agraz PhD

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Hello!

My name is: Jose Agraz

Visit my website at: www.joseagraz.com

6am-6:20pm

Or else

Questions?
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Guadalajara, Mexico, 1947

Breast Cancer
Career Women, 2010

What's this scary thing?

Breast Cancer
2nd Biggest Killer Among Women*

*American Cancer Society (ACS), Lung cancer is the leading disease in 2015

How does it affect the community?

1 of 8 Females
231,840 new cases in 2015

*ACS, 2nd most diagnosed after skin cancer in 2015

How does it affect the community?

17% Death Rate

40,290 expected to die in 2015*

How is the battle going?

Mortality Decrease
Since 1989, steady decrease in mortality
1. Largest in young white females*
2. Smallest in older black females*

*ACS, mortality decrease 2007 to 2011

Why the diagnosis & mortality differences?

Key to Survival
1. Early Diagnosis
2. Treatment

How early is early?

Early Diagnosis
1. Clinical Breast Exam

Breast Cancer

2. Mammography

Stage Number vs. Survival Rate

Survival Rate %

150
100
50
0
0

Cancer Stage Number

Stages 0 & 1 have a 100% survivability rate

A Path to Understanding These Diseases?

Molecular & Metabolic Imaging

Cell Level Detection
No Direct Technology

Succinate
Molecule

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What are the Current Screening Technologies?

Non-Imaging modalities
1. Biopsy
2. Blood Screening, e.g. PSA
3. Physical Examination

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What are the Current Screening Technologies?

Imaging modalities
1. Ultrasound
2. X-ray
3. PET CT
4. MRI

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How about a MRI with a little help from my friends?

MRI

*Pics courtesy of Jerusalems Shaare Zedek Medical Center

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MRI Add-On Enhancing Instrument

Versatile & Robust

1. Multiple Methods Capabilities
2. Sterile System
3. Long Term Stability

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What in the World is the PHIP?

upside
X20,000 Amplification!!

24mm

443m

US
Quarter
Empire State Building, NY
* Curtesy of Pratip Bhattacharya, MD Andersen Cancer Center

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My Research Contribution

PHIP Instrument
Instrument Designed, Built, And Tested

Inside View

Front View

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My Research Contribution

PHIP Instrument
Play Instrument Intro Movie here...

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My Research Contribution

PHIP Instrument
Play Instrument Intro Movie here...

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What is Nuclear Spin?

Wobble Spin=Polarization
Lots of Polarization = Hyper-Polarization
Hydrogen Polarization

Spinning Top Analogy

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What is PHIP?

Hydrogen

Carbon

PHIP
Para-Hydrogen Induced Polarization
Play para-Hydrogen Movie here...

Hydrogen spin transfer to Carbon

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The Key to PHIP

Para-hydrogen
Hydrogen to Carbon Spin Transfer

ortho-Hydrogen

para-Hydrogen
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Where is the Beef?

PHIP at Work

Play Molecule Experiment Movie here...

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Pig's heart

Heart Imaging
Play Pig's Heart Imaging Movie here...

* Curtesy of Pratip Bhattacharya, MD Andersen Cancer Center

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Pig's brain

Brain Imaging
Play Pig's Brain Imaging Movie here...

* Curtesy of Pratip Bhattacharya, MD Andersen Cancer Center

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Summary
1. PHIP Platform instrument Designed, Built, & Tested
2. Sterile Valve Hosing Setup
3. Ready for Model Trials

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conclusion

Unique problem
Great Potential to Safe Lives in the Future

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Acknowledgements

Shawn Wagner

Robert Pozos

Alex Grunfeld

Jess Mata

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Thank you

www.JoseAgraz.com
Questions?

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