April 6, 2015

Unit Five Nutrition Therapy for Hepatobiliary and Pancreatic Disorders

Case 13 Acute Pancreatitis

1. Describe the normal exocrine and endocrine functions of the pancreas.

The pancreas is a large digestive gland located behind the stomach. The
pancreas has two major functions endocrine and exocrine functions. The
pancreas is the only organ that has both exocrine and endocrine functions.
The exocrine functions produce enzymes necessary for digestion while the
endocrine functions produces hormones to regulate the use of body fuel,
mainly glucose.
2. Determine the potential etiology of both acute and chronic pancreatitis. What
information provided in the physical assessment supports the diagnosis of
acute pancreatitis?
Acute pancreatitis has some persisting symptoms. These symptoms include
upper abdominal pain that normally worsens with ingestion of food. The
mechanism that leads to pancreatic injury is not known, however there are
common characteristics like the premature activation of trypsin within the
pancreas, resulting in auto digestion of the pancreatic cells. The enzymes
released by destroying by destroyed pancreatic cells eventually reach the
bloodstream, which causes elevated serum amylase and lipase levels. A
diagnosis of acute pancreatitis is based on clinical symptoms and abnormal
serum amylase and lipase levels.
Chronic pancreatitis is an irreversible inflammation, which leads to fibrosis
with tissue calcification. Signs and symptoms are chronic abdominal pain
and elevated pancreatic enzyme levels.
The patient described having increasing abdominal pain, which is a typical
symptom. He also complained of frequent nausea and which are both
associated with acute pancreatitis as well.
3. What laboratory values or other tests support this diagnosis? List all abnormal
values and explain the likely cause for each abnormal value.
The patient has several lab values that support the diagnosis of acute
pancreatitis. His LDH levels, AST levels, BUN levels, Serum cholesterol and
triglyceride levels, CRP levels, and WBC count are all elevated. The most
telling lab values are the extremely elevated Lipase and Amylase levels. The
high levels of bilirubin are common among pancreatitis patients. These are
what helped diagnose acute pancreatitis.
The patient has several other abnormal laboratory values. His high serum
osmolality, BUN, and creatinine all indicate that the patient is dehydrated.
There is an elevated level of alkaline phosphatase could be due to
inflammation in the liver. If there is inflammation, gallstones can form and
then block bile ducts, this then causes bile to collect and back up. This
backup causes damage to liver which in turn causes an increase in ALP
levels. ALT is alanine aminotransferase. The ALT levels are a biological
marker of gallstone pancreatitis. Creatine phosphokinase or CPK levels

could be elevated because of the inflammation in the patients muscle. CPK

is an enzyme found in muscles and CPK levels become elevated when there
is any kind of muscle damage or inflammation. Segs % and Bands % are
types of neutrophils. The neutrophils are elevated because they are a type of
white blood cells and elevated white blood cell count is typical among acute
pancreatitis patients. He also tested positive for Bilirubin and Urobilinogen, in
his urine. These all indicate that there is a problem in the in the some type of
biliary obstruction. Protein and Protein chk were both positive and this could
be seen in the urine of some patients with pancreatitis. The presence of
ketones is also a possible sign of pancreatic problems.
4. The physician lists an APACHE score in his note. What factors are used to
determine this score? What does this mean?
APACHE means Acute Physiology and Chronic Health Evaluation II and it is
a classification system in which the severity of the disease is calculated.
Values of 12 clinical measures are used from the first twenty-four hours after
admission. The patients age, chronic health conditions and physiological
variables are all taken into account when determining a score. The higher the
APACHE score, the more severe the disease and also the higher the risk of
death. The criteria used to get a score are: the age, Glasgow coma score,
temperature, MAP, heart rate, respiratory rate, FiO2 levels, PaO2 levels,
Arterial pH, Sodium levels, Potassium levels, Creatinine levels, whether or
not the patient had acute renal failure, hematocrit levels, and WBC. The
patients APACHE score was 4, this indicates that his severity of disease is
low and also that his mortality rate is low.
5. What are the potential complications of acute pancreatitis?
Potential complications of acute pancreatitis include shock, pulmonary failure,
renal failure, gastrointestinal bleeding, and multiorgan system failure.
6. Historically, the patient with acute pancreatitis was made NPO. Why? This
patient has an NG tube placedwhy?
Usually a patient with acute pancreatitis is made NPO because it is assuming
that not having the patient consume foods by mouth would stimulate the
pancreas and aggravate it causing even more inflammation of the pancreas.
This patient has an NG tube placed because he needs nutrients to his body
as soon as possible, but he also needs the food to be partially digested in
order for his body to be able to break them down. He stated that he has eaten
very little over the past three days because of pain, nausea, and vomiting, so
it is important that he gets some nutrients into him through enteral feeding
immediately.
7. The physician has written an order for a nutrition consult to start enteral
feedings. Using the most current literature and ASPEN guidelines, explain the
role of enteral feeding in acute pancreatitis. Do you agree with the initiation of
enteral feeding? Why or why not?

In past years, it was thought that pancreatic neglect was the best way to treat
pancreatitis, but now new research has been done with shows that
stimulating the gut with enteral nutrition is beneficial to the patient. Also,
parenteral nutrition is used as a last resort for patients, if they can process
food even a little bit then having them still use their digestive tract is important
to keep it functioning.
I agree with the initiation of enteral feeding in this patient, because it is
important he get nutrients using his digestive tract. Enteral feeding would
have the food already partially broken down so it would be easier for the
stomach to break down, which would reduce the pain. Also, if the digestive
tract is not used, then the patient could be at risk for the digestive tract to stop
working. Also,recent studies have shown that enteral nutrition helps patients
to recover faster over parenteral nutrition.
8. Does this patients case indicate the use of an immune-modulating formula?
According to current evidence, enteral feeding is prefered over parenteral
feeding. It is recommended that the tube feeding consists of supplements
such as omega-3 fatty acids, and other necessary vitamins. Immunemodulating formula is not recommended because extra supplementation is
not needed.
The patient shows signs of elevated WBC, which indicates an immune
response. This is probably due to the pancreatitis. Immune modulating
formula formula is not needed.
9. What research supports the use of probiotics in acute pancreatitis? Is there
any evidence supporting the use of supplemental glutamine?
There is conflicting evidence when it comes to the use of probiotics and its
effects in acute pancreatitis. Some studies have shown that there are positive
effects of using probiotics, but more recent studies have found opposite
results.
There is evidence supporting the use of supplemental glutamine in acute
pancreatitis patients. Studies show that glutamine supplementation reduced
the mortality rate of patients.
10. Assess Mr. Mahons height and weight. Calculate his BMI and % usual body
weight.
BMI:
BMI = ( Weight in Pounds / ( Height in inches x Height in inches ) ) x 703
(245 lbs / (71 in)^2) x 703 = 34 BMI Classified as obese
UBW: 195 lbs
%UBW = (100 x Actual Weight)/Usual body weight
= (100 x 245 lbs)/195 lbs = 126%

11. Evaluate Mr. Mahons initial nursing assessment. What important factors
noted in his nutrition assessment will affect your nutrition recommendations?
His excessive intake of alcohol, constant vomiting and nausea, and a steady
weight gain over the past 5 years would affect my nutrition recommendations
to him. His excessive amounts of alcohol intake puts more strain on his
pancreas because of the need to process the high amounts of alcohol,
causing oxidative stress to the gland. He would need to cut down on the
alcohol consumption or remove alcohol from his diet to allow his pancreas to
recover. His constant nausea and vomiting would affect my nutrition
recommendations because I would need to keep in mind that it is hard for him
to eat and keep food down. Supplements of vitamins and minerals may need
to be given to make sure he receives the appropriate amount of nutrients to
keep him healthy and in safe ranges of nutrient intake. His constant weight
gain over the past five years could make me recommend for him to decrease
his his caloric intake once he is able to keep food down again. I believe his
decrease in alcohol consumption would help with this issue, but counseling
him on a general healthy diet could help him decrease his weight to a healthy
BMI.
12. Determine Mr. Mahons energy and protein requirements. Explain the rational
method you used to calculate these requirements.
Energy Needs
Harris-Benedict Equation
Height: 511= 71 in = 180.34cm Weight: 245lb = 111.13kg Age: 29
Males: REE= 66.5 + 13.8 (weight in kg) + 5.0 (height in cm)- 6.8 (year old)
66.5 + (13.8 x 111.13kg) + (5 x 180.34) - (6.8 x 29)
66.5 + 1,533.6 + 901.7 - 197.2 = 2,305 kcal
Light activity : 2,305 X 1.3 = 2,997 kcal per day - to maintain weight
Protein Intake:
High levels of distress from abdomen pain
2 g/kg = 2g x 111.13kg = 222 g of protein daily
13. Determine Mr. Mahons fluid requirements. Compare this with the information
on the intake/output record.
30-40 cc/kg avg size adult and 18-54 yrs old
35cc = 35cc x 111.13kg = 3,890 cc or 3,890 ml
The information on the intake/output record says he is intaking 4,500mL and
he is output is 4,879mL per day. This information tells me that he needs more
fluid than his recommended fluid requirements and more fluid than his
nutrition chart suggests because he is losing more fluid than he is taking in.
This could lead to dehydration and cause other health complications.

14. From the nutrition history, assess Mr. Mahons alcohol intake. What is his
average caloric intake from alcohol each day using the information that he
provided to you?
His average caloric intake from alcohol would be about 1,100 kcals or more
from consuming about 11 alcoholic servings daily and more on weekends.
One serving of alcohol averages at about 100 kcals. He consumes 6 beers
and 4.5 shots daily, and more than that on weekends.
15. List all medication that Mr. Mahon is receiving. Determine the action of each
medication and identify any drug-nutrient interactions that you should monitor.
Drug

Mechanism of Action

Drug-nutrient interactions

Imipenen

inhibits bacterial cell-wall synthesis;

binds to penicillin-binding proteins

Alcohol should not be

consumed. Taking with meals
or on an empty stomach may
affect results - should be taken
in between meals.

Pepcid

H-2 histamine blocker. Reduces the

amount of acid in the stomach. Helps
to heal and prevent stomach ulcers,
and prevents symptoms like heartburn.

H-2 blockers inhibit B12

absorption, and are associated
with decreased iron
absorption.

Meperidine

Analgesic; acts as an agonist at the opioid receptor

Alcohol should not be

consumed or else dangerous
side effects or death can
occur.

Ondansteron

Antiemetic through inhibition of 5-HT3;

selective serotonin 5- HT3 receptor
antagonist.

Low levels of potassium or

magnesium in the blood may
also increase your risk of QT
prolongation (delayed
repolarization of the heart).

Milk of
Magnesia

Draws fluid from the body and retains

fluid thats in the lumen of the intestine,
thus stimulating nerves within the
colon wall, inducing peristalsis and
resulting in successful release of
colonic content

Interferes with absorption of

many nutrients, such as
thiamine.

Colace
(docusate)

Softens stool by allowing incorporation

of water and fat, by the reduction of
surface tension of the oil-water
interface of the stool.

Impacts magnesium levels and

increases amount of
potassium excreted in the
stool.

Ativan

CNS depressant.

Alcohol and other CNS

depressants should not be
consumed, as consumption
could lead to fatal respiratory
depression.

16. Identify the pertinent nutrition problems and the corresponding nutrition
diagnoses.
The patient has not been able to eat due to pain - inadequate oral/food
intake
The patient drinks 4-5 shots and 6 beers daily - excessive alcohol intake
Patient is diagnosed with acute pancreatitis, which compromises the
function of his pancreas - impaired nutrient utilization
17. Write you PES statement for each nutrition problem.
Inadequate oral intake, RT patient feeling pain resulting in loss of appetite,
AEB diagnosed acute pancreatitis secondary to N/V.
Impaired nutrient utilization, RT compromised pancreatic function AEB
excessive vomiting and diarrhea and significantly elevated liver enzymes
Lipase (980 U/L) and amylase (543 U/L).
Excessive alcohol intake, RT lack of nutrition education and/or
unwillingness to stop drinking, AEB 24-hour recall (4-5 shots of
bourbon/day and 6 beers/day).
21. If this patients acute pancreatitis resolves, what will be the recommendation
for him regarding nutrition and his alcohol intake when he is discharged?
Alcohol should be avoided, even well after he is recovered.
Supplementation of thiamin and folate, as well as a general multivitamin
would be wise due to take care of any deficiencies resulting from his
alcoholism. Once a liquid or solid diet is reached, the diet should consist of
high-protein, low-fat, easily digestible foods over 5-6 small meals.
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