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Other Drugs

Alprostadil
Bosentan
Epoprostenol

Latanoprost
Mesna
Succimer

Alprostadil
Vasodilator
Prostaglandin E1

IV infusion

Activates PG EP receptors

Local products

Vascular smooth m.
relaxation & vasodilation
Maintain PDA in neonates
awaiting surgery
IV infusion

Male erectile dysfunction


Local injection or pellets

Apnea
Hypotension
Arrhythmia
Prolonged/painful erection
lightheadedness

Bosentan
Vasodilator
Endothelin-1 receptor
antagonist
Blocks endothelin A & B
receptors
pulmonary vascular
resistance & dyspnea
Improves walking distance
Pulmonary arterial HTN

CI in pregnancy
Causes birth defects

serum aminotransferase
levels

Epoprostenol
Vasodilator
Naturally occurring
prostacyclin (PGI2)
Activated prostaglandin IP
receptors
Vascular smooth m.
relaxation

pulmonary blood flow &


reduces dyspnea
Pulmonary arterial HTN

Flushing
Hypotension
Tachycardia
Diarrhea
N, V

Latanoprost
Ocular hypotensive agent
Prostaglandin F2 analogue
Activates prostaglandin FP
receptors
aqueous humor outflow via
uveoscleral pathways
Lowers intraocular pressure
Chronic open-angle glaucoma
Topical ocular admin

Alters color of iris causing


permanent eye color change
by amount of melanin in
melanocytes

Mesna
Antidote
Sulfhydryl compound
Detoxifies urotoxic
metabolites acrolein of
ifosfamide &
cyclophosphamide
Hemorrhagic cystitis d/t
ifosfamide &
cyclophosphamide

Succimer
Antidote
Metal chelating agent
dimercaptosuccinic acid
Chelates lead
Water-soluble chelates to
excreted in urine

blood lead levels