Pro:

Typical papules with target features

Acral distribution
Mucous membrane erosions
Previous episodes

YES

YES

Is hospitalization needed?
NO

Is it EM?

MAYBE

Bopsy
Direct IF
Serum antibodies

What is the cause?

Con:
Transient lesions
Widespread erythema
Macules and blisters, flat targets
Subacute evolution

NO

Urticaria
ADR with some EM-like features
Autoimmune blisters
SJS

History of recurrent herpes

Cough, URT infection
Other patient infection, e.g., orf No Clue

HAEM
Possible HAEM

Acyclovir prophylaxis

MP-related EM

Post-infection EM
Positive

Herpes serology
Negative

Frequent recurrent

Idiopathic EM
Frequent recurrent
Azathioprine thalidomide