HUMERA

Pharmacologic Name
Adalimumab

Pharmacologic Class
BIOLOGIC RESPONSE MODIFIER
Tumor necrosis factor (TNF) blocker.
Tumor necrosis factorsrefer to a group
ofcytokinesthat can cause cell death (apoptosis).
Cytokinesare a broad and loose category of small
proteins that are important incell signalling.

Formulations
soln for SC inj - prefilled syringe n prefilled pen
10mg/0.2mL,
20mg/0.4mL,
40mg/0.4mL,
40mg/0.8mL;

Indications
rheumatoid arthritis
juvenile idiopathic arthritis
psoriatic arthritis
ankylosing spondylitis
plaque psoriasis
hidradenitis suppurativa
Crohn's disease
ulcerative colitis

Mechanism of action
Psoriasis is a chronic, inflammatory disease/ immune
mediated disease.
The interaction of multiple immune cell types including
T-cells, macrophages, and dendritic cells induces
abnormally rapid keratinocytic proliferation and
incomplete maturation.
These abnormalities result in thickening and scaling of
the skin.
Increased levels of TNF are found in psoriasis plaques.

 The mechanism of action of adalimumab is primarily

linked to the neutralization of TNF-alpha bioactivity by
preventing the interaction of TNF-alpha with the cell
surface TNF receptors
Through this mechanism, adalimumab inhibits several
TNF-alpha-induced events, ie, the release of serum
cytokines

side effects
injection site reactions
hives;
difficulty breathing;
swelling of your face, lips, tongue, or throat.
Because adalimumab suppressesTNF, which is part of
the immune system, latent infections, such
astuberculosis, can be reactivated, and the immune
system may be unable to fight new infections

 Abdominal or stomach fullness

body aches or pain
cough or hoarseness
ear congestion
gas with abdominal or stomach pain
lightheadedness
loss of voice
lower back or side pain
muscle aches and pains
nasal congestion
pain or tenderness around the eyes or cheekbones
rapid and sometimes shallow breathing
shivering
sunken eyes
thirst
trouble sleeping
warmth on the skin
wrinkled skin

Stop drug n report pt education

fever, night sweats, weight loss, tiredness;
feeling full after eating only a small amount;
pain in your upper stomach that may spread to your
shoulder;
easy bruising or bleeding, pale skin, feeling...
Do not giveLIVE VIRUS VACCINESto patient on
adalimumab