L 1 loi virus c pht hin vo 1953, thuc h

Adenoviridae. Vi 50 type gy cho con ngi 1 s

bnh cnh sau: vim h hp trn, vim phi, vim
thanh qun, vim kt mc mt, au mt , vim
hch mc treo rut.
Vn t ra l:

- y l loi virus no?

- Tnh cht sinh hc ca loi virus ny khc vi loi
khc ntn?
- C ch gy nn nhng bnh cnh trn ntn?
- Cc XN vi sinh no gip chn on loi virus ny?
- Cch phng bnh?

ADENOVIRUS

MC TIU
1.Nhn thc c kh nng gy bnh ca Adenovirus
2.M t tnh cht vi sinh ca cc Adenovirus
3.Nu 6 bnh cnh lm sng do Adenovirus gy ra
4.K 3 phn ng huyt thanh hc dng chn on

virus hc
5.Nu c cch phng bnh do Adenovirus gy ra

TNH CHT SINH HC

D = 60-70 nm

252 capsomer

TNH CHT SINH HC

Nui cy

TB thn phi ngi

TB Hela (thch hp nht)
Chu k nhn ln 30h/ln
Sc khng

Sng: + 360C (14 ngy)

+ 40C (7 ngy)
B tiu dit: Nc si, tia cc tm, chloramin 1%

TNH CHT SINH HC

Khng nguyn
+ Kt hp vi b th
+ Gy ngng kt hng cu
+ To khng th trung ha

PHN NG KT HP B TH
HE THONG TH
KT ac hieu
muon tm

KN ac hieu
Bo the

HE THONG CH
TH

Phc hp KN-KT
tieu thu het
bo the

HC con nguyen
ven

Bo the

KN ac hiu

Mau th khong
co KT ac hieu
muon tm

Bo the
khong
b tieu thu

HCC b ly giai

Mau th
khong
co
khang
the ac
hieu

Khang
nguyen gay
hieu qua
sinh hoc

Khang
nguyen
khong b KT
trung hoa

Khang nguyen gay hieu qua

sinh hoc

PHN NG TRUNG HA
Tu hong cau
(KN cum, arbovirus)

Ly giai hong cau

(KN Streptolysin O)

Gay chet
chuot
(Cac oc
to)

Huy hoai te bao

(Virus, oc to)

Mau th co
khang the ac
hieu

Khang
nguyen gay
hieu qua
sinh hoc

Khang
nguyen b
KT trung hoa

Hieu qua sinh hoc cua khang nguyen

b trung hoa

PHN NG TRUNG HA

Ngan tu hong cau

(HI [+])

Hong cau khong b ly

giai
(ASO [+])

Bao ve chuot khong b

chet (LD50)

Bao ve cay te bao

(CPE50)

NGAN TU HONG CAU

Mau th
co
KN muon tm

Mau th
khong co
KN muon tm

KT ac hieu
KN muon tm

Phc hp
KN-KT

HC a gan
KN

HC khong tu

HC tu lai
KT ac hieu
KN muon tm

KT con t do

HC a gan
KN

Ngan tu hong cau

Huyet thanh hoc tm khang nguyen ac hieu
(HCG)

Xt nghim gip chn on

1. Phn lp virus:
Bnh phm
(dch hng, mi, mt, phn, nc tiu)
T bo HEP-2 v KB
Tn thng t bo (2 tun)
nh danh

Xt nghim gip chn on

2. Chn on huyt thanh hc:
Phn ng trung ha => nh type
Phn ng ngn ngng kt hng cu=> nh nhm
Phn ng kt hp b th: khng th xut hin sau

15 ngy, ti a 3 tun

ng ly v dch t hc:
ng ly: h hp, phn-ming, tay-mt
Dch t hc:

5-15 % nguyn nhn gy tiu chy cp tr em

5-18% tr cha virus m khng mc bnh
Gy dch au mt vi tc lan nhanh

Phng bnh
Khng c hiu:

Gio dc sc khe cng ng, v sinh c

nhn, v sinh n ung, tit trng k cc trang
thit b khm mt.
c hiu:

Vaccin sng gim ng lc (type 3, 4, 5, 7)

Vaccin cht (type 3, 4, 7)