Species or

Endpoint of Route of
Effect Test- Sex Concentration Method Further Details Comment Reference
Effect Application
System

neurotoxici MMI CF-1 male intravenous 644 mg/kg 22-30 g mice; MMI: minimal motor No effect Lian, Huiling;
ty albino mice received impairment; title comp. in Steiner, Solomon
mouse title comp. in 0.1 percent S.; Sofia, R. Duane;
microspheres; methylcellulose in 0.9 Woodhead, Jose H.;
mice were paced percent saline solution Wolf, Harold H.;
on a rotating road adjusted to pH 6.2 was White, H. Steve;
(6 rpm); inability encapsulated into Shen, Gregory S.;
of mice to microspheres by a Rhodes,
maintain suspension/precipitation Christopher A.;
equilibrium for 1 method McCabe, R. Tyler
min was Journal of
estimated as MMI; Pharmaceutical
evaluation of Sciences, 2000 ,
toxic effect of title vol. 89, # 7 p. 867
comp. - 875
Title/Abstract Full
Text Scopus

antiepilepti MES CF-1 male intravenous 193.4 mg/kg 22-30 g mice; title comp. microspheres No effect Lian, Huiling;
c albino mice received in 0.1 percent Steiner, Solomon
mouse title comp. in methylcellulose in 0.9 S.; Sofia, R. Duane;
microspheres; 2 h percent saline solution Woodhead, Jose
after dosing, adjusted to pH 6.2 were H.; Wolf, Harold
current was prepared by a H.; White, H.
delivered to mice suspension/precipitation Steve; Shen,
by corneal method Gregory S.;
electrodes to Rhodes,
evoke maximal Christopher A.;
threshold seizures McCabe, R. Tyler
(50 mA); Journal of
efficiency of title Pharmaceutical
comp. against Sciences, 2000 ,
maximal vol. 89, # 7 p. 867
electroshock - 875
(MES) estim. Title/Abstract Full
Text Scopus