Escolar Documentos
Profissional Documentos
Cultura Documentos
Diseased Science
It is more important to know what sort of person has a disease than to know
what sort of disease a person has. attributed to Hippocrates
Arturo Casadevall and Ferric C. Fang
We have recently observed a widespread affliction of scientists known as impact factor mania (1), also referred to
as impactis (2), for which there appears to be no cure. This
has led us to consider whether additional unrecognized
medical conditions may be unique or overrepresented
among scientists.
Ahypothesemia. Characterized by the absence of a hypothesis. Some scientists have hypothesized that this is a
problem (3). See also hypothesosis.
Amnesia Originosa. An inability to recall the actual
origin of an idea that one now regards as ones own.
Afflicted individuals are able to present others ideas as
their own without guilt or attribution to the original
source.
Appendiceal Hypertrophy. A relatively new condition
that frst became manifest when journals began to allow
supplementary data. Authors suffering from appendiceal
hypertrophy stuff their papers with supplementary data
irrespective of its relevance, perhaps hoping to induce data
overload and reviewer fatigue. Reviewers, in particular
those suffering from experimentitis infnitum (see below),
may aggravate appendiceal hypertrophy by demanding
additional information of uncertain value. Preventive
measures include charging extra fees for supplementary
data analogous to the taxes imposed on tobacco use.
Areproducibilia. The inability to obtain the same experimental result twice (4). This is not necessarily a problem for individuals who publish irreproducible results and
simply move on to leave other scientists to deal with the
problems (5, 6). However, recurrent areproducibilia may
impair scientifc reputation as subsequent work by the
individual is not considered credible.
Borderline Probability Disorder. Afflicted individuals
may dismiss the potential importance of results with P
0.06 while unquestioningly accepting the importance of
results with P 0.05 (7). See also signifcosis.
CNS Depression. The feeling after ones paper has been
rejected by Cell, Nature, and Science (1). The malady generally abates once the paper is published in a lower-tier
journal.
Dogmatitis. 1. Manifested by a courageous adherence
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10. Walbot, V. 2009. Are we training pit bulls to review our manuscripts?
J. Biol. 8:24.124.3.
14. Casadevall, A., and F. C. Fang. 2013. Is the Nobel Prize good for
science? FASEB J. 27:4682 4690.
15. Casadevall, A., and F. C. Fang. 2009. Is peer review censorship? Infect.
Immun. 77:12731274.
12. Casadevall, A., and F. C. Fang. 2009. Mechanistic science. Infect. Immun. 77:35173519.
16. Casadevall, A., and F. C. Fang. 2012. Winner takes all. Sci. Am. 307:13.
17. Casadevall, A., and F. C. Fang. 2009. Important scienceits all about
the SPIN. Infect. Immun. 77:4177 4180.
Molecular Genetics
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