Usual Doses of Commonly Prescribed Antibiotics

Pediatric (Age >

1 mo) Dose
Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

N/A

57.5
mg/kg
IV q 12
h

1.52.5
mg/kg IV
q 2448
h

57
mg/kg IV
once/day

N/A

12.5
mg/kg
IV q 8 h

0.34
0.51
mg/kg IV
q 2448
h

N/A

N/A

1
mg/kg
IV q 8 h

Infectiou
s
disease
consulta
tion
required
for

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

N/A

15 mg/kg
IV
once/day

15 mg/kg
IV
once/day

or

or

Oral

Aminoglycosides
Amikacin

7.5 mg/kg 7.5 mg/kg

q 12 h
IV q 12 h
Gentamicin

N/A

57
mg/kg IV
once/day
or
1.7 mg/kg
IV q 8 h

For synergy with a cell

wallactive antibiotic to
treat enterococcal
endocarditis caused by
strains susceptible
to gentamicin

N/A

1 mg/kg
IV q 8 h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
dosage
Dosage
adjusted
to
achieve
peak
serum
concentr
ation of
34 g/
mL and
trough
concentr
ation
of < 1
g/mL

For streptococcal
or Staphylococcus
aureus endocarditis

1 mg/kg
IV q 8 h
or
3 mg/kg
IV
once/day

N/A

N/A

1
mg/kg
IV q 8 h
or
3
mg/kg
IV
once/da

N/A

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

y
Neomycin
For preoperative gut
antisepsis
(with erythromycin and
mechanical cleansing)

For hepatic coma

1 g for 3
N/A
doses
(eg, at 1,
2, and 11
pm on the
day
before
surgery)

N/A

13 g qid

N/A

N/A

15
mg/kg
q4h
for 2
days

N/A

N/A

N/A

N/A

or
25
mg/kg
at 1, 2,
and 11
pm on
the day
before
surgery
0.6
1.75
g/m 2q
6h
or
0.41.2

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

g/m 2q
4h
Streptomycin
For TB

N/A

15 mg/kg N/A
IM q 24 h
(maximu
m: 1.0
g/day)
initially,
then 1.0 g
23
times/wk

N/A

2040
mg/kg
IM
once/da
y

7.5
mg/kg
IM q 72
96 h
(maximu
m: 1 g)

For synergy with a cell

wallactive antibiotic to
treat enterococcal
endocarditis

N/A

7.5 mg/kg N/A

IM q 12 h

N/A

N/A

N/A

Tobramycin

N/A

57
mg/kg IV
once/day

57
mg/kg IV
once/day

N/A

12.5
mg/kg
IV q 8 h

or

or

0.34
0.51
mg/kg IV
q 2448
h

1.7 mg/kg 1.7 mg/kg

IV q 8 h
IV q 8 h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

-Lactams: Cephalosporins (1st generation)

Cefadroxil

0.51 g q
12 h

N/A

N/A

15
mg/kg
q 12 h

N/A

0.5 g po
q 36 h

Cefazolin

N/A

12 g IV q
8h

2 g IV q 8
h

N/A

16.6
33.3
mg/kg
IV q 8 h

12 g IV
q 2448
h

Cephalexin

0.250.5
gq6h

N/A

N/A

6.25
12.5
mg/kg
q6h

N/A

0.250.5
g po q
2448 h

N/A

0.5 g po
q 12 h

or
8.016
mg/kg
q8h
-Lactams: Cephalosporins (2nd generation)
Cefaclor b

0.250.5
gq8h

N/A

N/A

1020
mg/kg
q 12 h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

or
6.6
13.3
mg/kg
q8h
Cefotetan

N/A

13 g IV q
12 h

23 g IV q
12 h

N/A

2040
mg/kg
IV q 12
h

13 g IV
q 48 h

Cefoxitin

N/A

1 g IV q 8 2 g IV q 4
h to 2 g IV h
q4h
or

N/A

2733
mg/kg
IV q 8 h
or, for
severe
infectio
ns, 25
40
mg/kg
q6h

0.51.0
g IV q
2448 h

15
mg/kg
q 12 h
for
otitis

N/A

0.25 g
po q 12
24 h

3 g IV q 6
h

Cefprozil

0.25 g q
12 h
or

N/A

N/A

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

0.5 g q
1224 h
Cefuroxime

0.1250.5
g q 12 h

Oral

Parente
ral

media
0.751.5
g IV q 68
h

1.5 g IV q
6h

1015
mg/kg
suspen
sion q
12 h

2550
mg/kg
IV q 8 h

3 g IV q 8
h

0.250.5
g po q
24 h
or
0.75 g IV
q 24 h

For
older
children
: 125
250 mg
tablets
q 12 h
For meningitis

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

5060
mg/kg
IV q 6 h

N/A

8.3
33.3
mg/kg
IV q 4 h

12 g IV
q 24 h

-Lactams: Cephalosporins (3rd generation)

Cefotaxime

N/A

1 g q 12 h 2 g IV q 4
to 2 g IV q h
4h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

or
16.6
66.6
mg/kg
q6h
Cefpodoxime c

0.10.4 g
q 12 h

N/A

N/A

5
mg/kg
q 12 h

N/A

0.10.4
g po q
24 h

Ceftazidime

N/A

1 g IV q
12 h to 2
gq8h

2 g IV q 8
h

N/A

2550
mg/kg
IV q 8 h

0.5 g IV
q 2448
h

Ceftibuten b

0.4 g q 24 N/A
h

N/A

9
N/A
mg/kg
once/da
y

0.1 g po
q 24 h

Ceftriaxone

N/A

2 g IV q
24 h

N/A

Same as
adult
dose

12 g IV q
24 h

5075
mg/kg
IV q 24
h
or
2537.5
mg/kg

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

q 12 h
For meningitis

N/A

2 g IV q
12 h

2 g IV q
12 h

N/A

50
mg/kg
IV q 12
h or
100
mg/kg
q 24 h
(not to
exceed
4
g/day)
Possibly
a
loading
dose of
100
mg/kg
IV (not
to
exceed
4 g) at
the
start of
therapy

2 g IV q
12 h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

-Lactams: Cephalosporin (4th generation)

Cefepime

N/A

12 g IV q
812 h

2 g IV q 8
h

N/A

50
mg/kg
IV q 8
12 h

0.251 g
IV q 24 h

N/A

0.2 g IV
q 12 h

-Lactams: Cephalosporin (5th generation)

Ceftaroline

N/A

0.6 g IV q
12 h

0.6 g IV q
12 h

N/A

0.250.5
gq8h

N/A

N/A

12.525 N/A
mg/kg
q 12 h

-Lactams: Penicillins
Amoxicillin

or

or

0.875 g q
12 h

For endocarditis
prophylaxis

2 g for 1
dose

0.250.5
g po q
24 h

713
mg/kg
q8h
N/A

N/A

50
mg/kg
1h
before

N/A

2 g po
for 1
dose

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

procedu
re
Amoxicillin/clavulanate

0.250.5
gq8h

N/A

N/A

If > 40
kg:
Adult
dose

N/A

0.250.5
g po q
24 h

or
0.875 g q
12 h
Amoxicillin/clavulanate,
ES-600

N/A

N/A

N/A

45
mg/kg
q 12 h

N/A

N/A

Amoxicillin/clavulanate,
extended-release

2 g q 12 h N/A

N/A

N/A

N/A

N/A

Ampicillin

N/A

0.52.0 g
IV q 46 h

2 g IV q 4
h

N/A

2550
mg/kg
IV q 6 h

0.52.0
g IV q
1224 h

For meningitis

N/A

2 g IV q 4
h

2 g IV q 4
h

N/A

50100
mg/kg
IV q 6 h

2 g IV q
12 h

Ampicillin/sulbactam

N/A

1.53.0 g
IV q 6 h

3 g IV q 6
h

N/A

2550
mg/kg
IV q 6 h

1.53.0
g IV q 24
h

(3 g = 2
g ampicillin + 1 g

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Dicloxacillin b

0.1250.5
gq6h

N/A

N/A

3.125
6.25
mg/kg
q6h

N/A

Nafcillin

Rarely
used

12 g IV q
4h

2 g IV q 4
h

N/A

12.525 12 g IV
mg/kg
q4h
IV q 6 h

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

sulbactam)
0.125
0.5 g po
q6h

or
8.3
33.3
mg/kg
q4h
Oxacillin

Rarely
used

12 g IV q
4h

2 g IV q 4
h

N/A

12.525 12 g IV
mg/kg
q4h
IV q 6 h
or
8.3
33.3
mg/kg
IV q 4 h

Penicillin G b

0.250.5

14

4 million

Penicilli

6,250

0.52

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Serious
Infections

Oral

Parenteral

Oral

g q 612
h
(penicillin
V)

million
units IV q
46 h

units IV q
4h

n VK

1.2
million
units IM
for 1 dose

N/A

N/A

6.25
12.5
mg/kg
q8h

Dose in
Renal
Failure a
Parente (CrCl <
10
ral
mL/min)
100,00 million
0
units IV
units/kg q 46 h
IV q 6 h (maximu
m total
or
daily
4,166.6 dose: 6
66,666 million
units/kg units/da
IV q 4 h y)

Penicillin G benzathine (Bicillin L-A)

For streptococcal
pharyngitis

N/A

25,000
50,000
units/kg
IM as a
single
dose
or
If < 27
kg:
300,00
0
600,00
0 units

1.2
million
units IM
for 1
dose

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

as a
single
dose
or
If 27
kg: 0.9
million
units as
a single
dose
Prophylaxis for
rheumatic fever

N/A

1.2
million
units IM q
34 wk

N/A

N/A

25,000
50,000
units/kg
IM q 3
4 wk

1.2
million
units IM
q 34 wk

For early syphilis

N/A

2.4
million
units IM
for 1 dose

N/A

N/A

50,000
units/kg
IM for 1
dose

2.4
million
units IM
for 1
dose

For late syphilis

(excluding
neurosyphilis)

N/A

2.4
million
units
IM/wk for

N/A

N/A

50,000
units/kg
IM in 3
doses 1

2.4
million
units IM
for 1

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

3 wk
Penicillin G procaine (IM N/A
only)

0.30.6
million
units IM q
12 h

Parente
ral
wk
apart

N/A

N/A

25,000
50,000
units/kg
IM q 24
h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
dose
0.3 to
0.6
million
units IM
q 12 h

or
12,500
25,000
units/kg
IM q 12
h
Piperacillin (1.9 mEq
Na/g)

N/A

3 g IV q
46 h

3 g IV q 4
h

N/A

5075
mg/kg
IV q 6 h

34 g IV
q 12 h

or
33.350
mg/kg
IV q 4 h
Piperacillin/tazobactam
(2.25 g =2.0 g

N/A

3.375 g IV 3.375 g IV N/A

q 46 h
q4h

80
mg/kg

2.25 g IV
q 8 h to

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

piperacillin + 0.25 g
tazobactam)

Parente
ral
IV q 8 h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
4.5 g IV
q 12 h

Ticarcillin (5.2 mEq

Na/g)

N/A

3 g IV q
46 h

3 g IV q 4
h

N/A

If < 60
12 g IV
kg: 50
q 12 h
mg/kg
IV q 46
h

Ticarcillin/clavulanate (
3.1 g = 3 g
ticarcillin + 0.1 g
clavulanic acid)

N/A

3.1 g IV q
46 h

3.1 g IV q
4h

N/A

If < 60
2 g IV q
kg: 50
12 h
mg/kg
IV
(based
on
ticarcilli
n
compon
ent) q
46 h

N/A

12 g IV q
612 h

2 g IV q 6
h

N/A

3040
0.5 g IV
mg/kg
q8h
IV q 68
h

-Lactams: Monobactams
Aztreonam

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Ertapenem

N/A

1 g IV q
24 h

Imipenem

N/A

0.51.0 g
IV q 6 h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

Oral

Parente
ral

1 g IV q
24 h

N/A

N/A

0.5 g IV
q 24 h

1 g IV q 6
h

N/A

For
infants
4 wk to
3 mo:
25
mg/kg
IV q 6 h

0.125
0.25 g IV
q 12 h
(may
increase
risk of
seizures)

-Lactams: Carbapenems

For
children
>3 mo:
1525
mg/kg
IV q 6 h
Meropenem

N/A

1 g IV q 8
h

2 g IV q 8
h

N/A

2040
mg/kg
IV q 8 h

0.5 g IV
q 24 h

Doripenem

N/A

0.5 g IV q
8h

0.5 g IV q
8h

N/A

N/A

0.25 g IV
q 24 h

For meningitis

40 mg/kg

40 mg/kg

N/A

20

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

IV q 8 h

IV q 8 h

0.20.4 g
IV q 812
h

0.4 g IV q
8h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
mg/kg IV
q 24 h

Oral

Parente
ral

1015
mg/kg
IV q 12
h (in
select
circums
tances)

1015
mg/kg
IV q 12
h (in
select
circums
tances)

0.50.75
g po q
24 h

Fluoroquinolones d
Ciprofloxacin

0.50.75
g q 12 h

or
0.20.4
g IV q 24
h

Extended-release for
uncomplicated cystitis

0.5 g q 24 N/A
h for 3
days

N/A

N/A

N/A

N/A

Gemifloxacin

320 mg q
24 h

N/A

N/A

N/A

N/A

160 mg
po q 24
h

Levofloxacin

0.250.75
g q 24 h

0.250.75
IV g q 24
h

0.75 g IV
q 24 h

N/A

N/A

0.250.5
g po or
IV q 48 h

Moxifloxacin

0.4 g q 24 0.4 g IV q
h
24 h

0.4 g IV q
24 h

N/A

N/A

0.4 g q
24 h po

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
or IV

Norfloxacin b

0.4 g q 12 N/A
h

N/A

N/A

N/A

0.4 g po
q 24 h

Ofloxacin

0.20.4 g
q 12 h

0.4 g IV q
12 h

0.20.4 g
IV q 12 h

N/A

N/A

0.10.2
g po or
IV q 24 h

Azithromycin

0.5 g on
day 1,
then 0.25
g q 24 h
for 4 days

0.5 g IV q
24 h

0.5 g IV q
24 h

N/A

0.5 g po
on day
1, then
0.25 g
po q 24
h for 4
days or
0.5 g IV
q 24 h

For nongonococcal
cervicitis and urethritis

1 g for 1
dose

N/A

N/A

N/A

N/A

N/A

For travelers diarrhea

1 g for
1dose

N/A

N/A

510
mg/kg
for 1
dose

N/A

N/A

Macrolides

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

For tonsillitis or
pharyngitis

N/A

N/A

N/A

12
mg/kg
for 5
days

For otitis media or

community-acquired
pneumonia

N/A

N/A

N/A

10
N/A
mg/kg
on day
1, then
5
mg/kg
once/da
y on
days 2
5

N/A

Clarithromycin

0.250.5
g q 12 h

N/A

N/A

7.5
mg/kg
q 12 h

N/A

0.250.5
g po q
24 h

N/A

N/A

1016.6 N/A
mg/kg
q8h

0.25 g
po q 6 h

Extendedrelease: 1
g q 24 h
Erythromycin base b

0.250.5
gq6h

Oral

or

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
N/A

N/A

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

7.5
12.5
mg/kg
q6h
Fidaxomicin

0.2 g q 12 N/A
h

N/A

N/A

N/A

0.2 g po
q 12 h

Lactobionate

N/A

0.51 g IV
q6h

1 g IV q 6
h

N/A

3.75
5.0
mg/kg
IV q 6 h

0.5 g IV
q6h

Gluceptate

N/A

0.51 g IV
q6h

1 g IV q 6
h

N/A

3.75
5.0
mg/kg
IV q 6 h

0.5 g IV
q6h

For GI preoperative
bowel preparation

1 g for 3
doses

N/A

N/A

20
mg/kg
for 3
doses

N/A

N/A

Telithromycin

800 mg q
24 h

N/A

N/A

N/A

N/A

800 mg
po q 24
h

Sulfonamides and trimethoprim

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug

Sulfisoxazole

Oral

Parenteral

1.0 g q 6
h

25 mg/kg
IV q 6 h
(not
available
in US)

Serious
Infections
N/A

Oral

Parente
ral

3037.5 N/A
mg/kg
q6h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
1 g po q
1224 h

or
2025
mg/kg
q4h

Sulfamethizole

0.51 g q
68 h

N/A

N/A

7.5
11.25
mg/kg
q6h

N/A

N/A

Sulfamethoxazole

1 g q 8
12 h

N/A

N/A

2530
mg/kg
q 12 h

N/A

1 g po q
24 h

Trimethoprim

0.1 g q 12 N/A
h

N/A

2
N/A
mg/kg
q 12 h
for 10
days for
UTI

0.1 g po
q 24 h

5 mg
TMP/kg IV

36 mg
TMP/kg

(Not
recomm

or
0.2 g q 24
h
Trimethoprim/sulfameth 0.16/0.8 g 35 mg
oxazolee
q 12 h
TMP/kg IV

36 mg
TMP/kg

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

For Pneumocystis
jiroveciipneumonia e

Parenteral

Serious
Infections

Oral

q 68 h

q6h

q 12 h

IV q 12
h

5 mg
TMP/kg IV
q 68 h

56.6
mg
TMP/kg
q8h

56.6
mg
TMP/kg
IV q 8 h

or

or

3.755
mg
TMP/kg
q6h

3.755
mg
TMP/kg
IV q 6 h

Age > 8
yr: 24
mg/kg
q 24 h

Age > 8 0.1 g IV

yr: 24
or po q
mg/kg
12 h
IV q 24
h

0.32/1.6 g 5 mg
q 8 h for
TMP/kg IV
21 days
q 8 h for
21 days

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
ended if
other
alternati
ves are
available
)
If
essential
, 5 mg
TMP/kg
IV q 24 h
or
1.25 mg
TMP/kg
IV q 6 h

Tetracyclines
Doxycycline

0.1 g q 12 0.1 g IV q
h
12 h

0.1 mg IV
q 12 h

or

or

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

12
mg/kg
q 12 h

12
mg/kg
IV q 12
h
N/A

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

Minocycline

0.1 g q 12 0.1 g IV q
h
12 h

0.1 g IV q
12 h

N/A

Tetracycline b

0.250.5
gq6h

N/A

N/A

Age > 8 N/A

yr:
6.25
12.5
mg/kg
q6h

Doxycycl
ineused
instead

Tigecycline

N/A

100 mg,
then 50
mg (25
mg for
severe
hepatic
dysfuncti
on) IV q
12 hr

Same as
adult
dose f

N/A

Same as
adult
dose

Others

N/A

0.1 g IV
or po q
12 h

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug

Clindamycin

Oral

Parenteral

0.150.45
gq6h

0.6 g IV q
6 h to 0.9
IV g q 8 h

Serious
Infections
0.9 g IV q
8h

Oral
2.66.6
mg/kg
q8h
or
25
mg/kg
q6h

Parente
ral
6.6
13.2
mg/kg
IV q 8 h
or
510
mg/kg
IV q 6 h

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
0.15
0.45 g
po q 6 h
or
0.60.9
g IV q 6
8h

Chloramphenicol

0.251 g
q6h

0.251.0
g IV q 6 h

1 g IV q 6
h

N/A

12.5
18.75
mg/kg
IV q 6 h

0.251.0
g IV q 6
h

For meningitis

N/A

12.5
mg/kg q 6
h
(maximu
m: 4
g/day)

12.5
mg/kg IV
q6h
(maximu
m: 4
g/day)

N/A

18.75
25
mg/kg
IV q 6 h

12.5
mg/kg IV
q6h
(maximu
m: 4
g/day)

Colistin (polymyxin E)

N/A

2.55
mg/kg/da
y IV in 2
4 doses

2.55
mg/kg/da
y IV in 2
4 doses f

N/A

N/A

1.5
mg/kg q
36 h

Dalbavancin

N/A

1000 mg

1000 mg

N/A

N/A

1000 mg

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

as a
single
dose,
followed
by a 500mg dose
1 wk later

as a
single
dose,
followed
by 500mg dose
1 wk later

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
as a
single
dose,
followed
by a
500-mg
dose 1
wk later

Daptomycin

N/A

46
mg/kg IV
q 24 h

810
mg/kg IV
q 24 h f

N/A

N/A

46
mg/kg IV
q 48 h

Fosfomycin

A single
dose of 3
g in 34
oz of
water

N/A in US

N/A

N/A

N/A

A single
dose of
3 g in 3
4 oz of
water

Linezolid

0.6 g q 12 0.6 g IV q
h
12 h

0.6 g IV q
12 h

10
mg/kg
q8h

10
mg/kg
IV q 8 h

0.6 g IV
or po q
12 h

7.5 mg/kg 7.5 mg/kg 7.5 mg/kg 7.5

q 6 h (not IV q 6 h
IV q 6 h
mg/kg
to exceed (not to
(not to
q6h

7.5
mg/kg
IV q 6 h

3.75
mg/kg IV
or po q 6

Metronidazole
For anaerobic infection

Pediatric (Age >

1 mo) Dose

Adult Dose

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
h (not to
exceed 2
g/day)

N/A

N/A

N/A

250 mg
po or IV
q8h

Drug

For trichomoniasis

Oral

Parenteral

Serious
Infections

4 g/day)

exceed 4
g/day)

exceed 4
g/day)

2 g for 1
dose

N/A

N/A

or
0.5 g q 12
h for 7
days
For Clostridium difficile
induced diarrhea
(pseudomembranous
colitis)

0.5 g q 6
8 h for
1014
days

500 mg IV 500 mg IV 7.5

q 68 h
q6h
mg/kg
q8h

7.5
mg/kg
IV q 6 h

For amebiasis

0.50.75
gq8h
for 10
days
followed
byparomo
mycinpo
0.5 g q 8
h for 7
days

0.75 g IV
q 8 h for
10 days
followed
byparomo
mycinpo
0.5 g q 8
h for 7
days

11.6
N/A
16.6
mg/kg
IV q 8 h
for 7
10 days

0.75 g IV
q 8 h for
10 days
followed
byparomo
mycinpo
0.5 g q 8
h for 7
days

11.6
16.6
mg/kg
q8h
for 7
10 days

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

0.25 g q
68 h for
57 days

N/A

N/A

5
mg/kg
q 68 h
for 5
days

N/A

Nitrofurantoin macrocry 50100

stals
mg q 6 h

N/A

N/A

1.25
1.75
mg/kg
q6h

N/A

Not
recomm
ended

Nitrofurantoinmonohyd
rate/macrocrystals

100 mg q
12 h

N/A

N/A

N/A

N/A

N/A

Oritavancin

N/A

1200 mg
as a
single
dose

1200 mg
as a
single
dose

N/A

N/A

1200 mg
as a
single
dose

Quinupristin/dalfopristi
n

N/A

7.5 mg/kg 7.5 mg/kg N/A

IV q 812 IV q 8 h
h

7.5
mg/kg
IV q 12
h for
complic
ated
skin or
skin
structur

7.5
mg/kg IV
q 812 h

For giardiasis

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
N/A

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

e
infectio
n
or
7.5
mg/kg
q8h
for
serious
infectio
ns
Rifampin b
For TB

0.6 g q 24 0.6 g IV q
h
24 h

N/A

510
mg/kg
q 12 h
or

1020
mg/kg
IV q 24
h

0.30.6
g IV or
po q 24
h

1020
mg/kg
q 24 h
For meningococcal
exposure

0.6 g q 12 N/A
h for 4
doses

N/A

Age 1 N/A
mo: 10
mg/kg

0.6 g po
q 12 h
for 4

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

q 12 h
for 2
days

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
doses

Age < 1
mo: 5
mg/kg
q 12 h
for 2
days
For Haemophilus
influenzaeexposure

For staphylococcal
infections (used with a
penicillin,
cephalosporin,

20 mg/kg
q 24 h for
4 days
(not to
exceed
600 mg q
24 h)

N/A

N/A

0.3 g q 8
h

0.3 g IV q
8h

0.3 g IV q
8h

or

or

or

20
mg/kg
q 24 h
for 4
days

N/A

20
mg/kg q
24 h for
4 days
(not to
exceed
600 mg
q 24 h)

0.3 g IV
or po q 8
h

Age < 1
mo: 10
mg/kg
q 24 h
for 4
days

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug

orvancomycin)

Oral

Parenteral

Serious
Infections

0.60.9 g
q 24 h

0.60.9 g
IV q 24 h

0.60.9 g
IV q 24 h

Initial
phase (2
mo): 0.6
g
twice/wk

N/A

N/A

N/A

N/A

N/A

N/A

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
or
0.60.9
g IV or
po q 24
h

Rifapentine
For pulmonary TB (as
part of a 3- or 4- drug
regimen)

Continuati
on phase
(4 mo):
0.6 g
once/wk
For latent TB (in
combination
withisoniazid)

0.9 g
once/wk
(3 mo)

N/A

N/A

N/A

N/A

Tedizolid

200 mg q
24 h

200 mg IV 200 mg IV N/A

q 24 h
q 24 h

N/A

200 mg
po or IV
q 24 h

Pediatric (Age >

1 mo) Dose
Oral

Parente
ral

10 mg/kg
IV q 24 h

N/A

N/A

Dose in
Renal
Failure a
(CrCl <
10
mL/min)
N/A

15 mg/kg
IV q 12 h

N/A

13
mg/kg
IV q 8 h

0.51.0
g IV q
wk

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Telavancin

N/A

10 mg/kg
IV q 24 h

Vancomycin

125 mg q
6 h (only
effective
for C.
difficile
induced
diarrhea

15 mg/kg
IV q 12 h
(often 1 g
q 12)

N/A

1 g IV q 8
h

1 g IV q 8
h

or

or

1.5 g IV q
12 hg

1.5 g IV q
12 h

For meningitis

or
10
mg/kg
IV q 6 h
N/A

15
mg/kg
IV q 6 h

15
mg/kg IV
q wk

a Initial loading dose should be equivalent to the usual dose for patients with normal
renal function, followed by a dose adjusted for renal failure. Dosing adjustments of
aminoglycosides should be assisted by measuring peak (drawn 1 h after the start of a
30-min IV infusion) and trough (drawn 30 min before next dose) serum levels.
b Rate or extent of absorption is decreased when the drug is taken with food.

Pediatric (Age >

1 mo) Dose

Adult Dose
Drug
Oral

Parenteral

Serious
Infections

Oral

Parente
ral

Dose in
Renal
Failure a
(CrCl <
10
mL/min)

c Dosage should not exceed that for adults.

d These drugs are generally avoided in children.
e Dose is based on TMP.
f The standard of care for dosing of this antibiotic for serious infections is complex and
rapidly evolving (see discussion of individual drug for a more information).
g In addition, intrathecal or intraventricular vancomycin 1020 mg/day may be
necessary, and dose may need to be adjusted to achieve trough CSF levels of 10
20 g/mL.
N/A = not applicable; TMP = trimethoprim.