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what is the order of synthesis for the catecholamines tyrosine (amino acid) -- L-dopa -dopamine -- norepinephrine -- epinephrine
(totally love dat naked ear)
neurotransmitter
-released by what
-binds where
-stays within what usually -term itself: when used, it typically implies that the chemical is
being released by NEURAL terminals
-also implies that it is binding to receptors on POSTSYNAPTIC MEMBRANE of a neuron
-stay within the synapse for the most part (occasionally diffuse out and affect nearby
neurons)
2 mechanisms that clean up neurotransmitters and remove them from the synapse
-reuptake
-enzymes
reuptake
-what does it do
-found on what membrane
mechanism found on PRESYNAPTIC membrane
-like a tube, NTs are pulled back, reabsorbed by presynaptic membrane and recycled
-in terminals it's broken up by enzymes into subparts and those subparts are used to
make new NTs, which are then wrapped in vesicles, ready for use.
enzymes
break down NTs into inactive parts in synapse
-very specific enzymes depending on the neurotransmitter
epinephrine
-released by what (NT or HORMONE)
-commonly called...
-a NT that in certain parts of the nervous system, is released by NEURONS, but
more often it's functioning as a HORMONE (produced and released by ADRENAL
GLANDS, which sit atop each kidney. part of endocrine system). because it's
produced by endocrine glands, it gets into the bloodstream and affects other parts of
body
-commonly called ADRENALINE or the STRESS HORMONE
epinephrine as the "stress hormone" acts upon what and does what
-acts upon sympathetic nervous system
-helps to enhance and continue stimulating the sympathetic nervous system so you
can maintain your FIGHT OR FLIGHT RESPONSE
NOREPINEPHRINE
-mostly found where
-role?
-most often found in AUTONOMIC NERVOUS SYSTEM
-role in regulating ALERTNESS AND WAKEFULNESS (no resting!!)
norepinephrine levels:
-when they peak and drop
-levels peak: at times of higher STRESS, making you more alert and focused on
what's happening around you
-levels drop in afternoon: somewhere b/w 3 and 5 (afternoon slump)
-levels rise again early evening
-released at higher levels and affect the CNS LATER in the night as it approaches the
time for you to WAKE FROM SLEEP
dopamine
-found in what two places
-excitatory, inhibitory, or both
-found in motor system of CNS. substantia nigra (inhibitory effects here)
-sometimes excitatory, sometimes inhibitory effects
parkinsons
-issue with what neurotransmitter
-symptoms
-when do sometimes become obvious
-treatment
-issue with dopamine
-if the substantia nigra (whose job it is to inhibit other areas of the motor system) is
not controlled by dopamine, other neurons will fire faster, resulting in overactivity
-leads to development of tremors, uncontrollable muscle contractions, balance
problems
-symptoms are obvious when about 80% of the dopamine is lost from the substantia
nigra due to cell death or damage
-L-dopa helps patients manage symptoms (given so that when it reaches CNS, it will
stimulate production of dopamine). neurons that are still viable will increase their
production of dopamine to compensate for loss of dopamine due to damanged
neurons. can be taken or ingested peripherally
functions of dopamine
-control of movement
-learning and memory
-MAJOR ROLE IN ADDICTIONS (dopaminurgic system: network in brain that
seems to regulate our sense of PLEASURE).
dopaminurgic system
-network in brain that seems to regulate our sense of pleasure
-drugs w/ low rate of addiction don't stimulate it usually
-natural behaviors (sex and eating) stimulate it
-elevated levels of dopamine function as reward
mao inhibitors
drugs/chemicals that inhibit the activity of mao, resulting in more monoamine NTs
in synapse for longer time
serotonin
-often inhibitory or excitatory
-involved in regulation of...
-plays role in (3 things)
often has inhibitory effects
-involved in regulation of MOOD (related to RELAXATION). elevated levels mean a
more relaxed state
-also plays role in eating behaviors, regulation of sleep, and state of arousal
autoreceptor
-located where
-why that name
-role
-what they do
-located on presynaptic membrane
-called autoreceptors b/c the terminal monitors itself
-regulate the cell so that it's not over or underproducing
-if a lot of NT is being released, all the extra will be forced to bind to autoreceptors,
which send feedback to terminal saying 'there's too much NT!'. this feedback
SLOWS THE RATE OF SYNTHESIS so production of NT slows and vesicles don't
release as much NT
1. Synthesized (created) 2. Put the neurotransmitters in a specific place so they can be used
(stored in synaptic Vesicle) 3. Some neurotransmitters leak out and are destroyed 4.
Exocytosis 5. Auto receptors inhibit any more release of presynaptic neuron 6.
Neurotransmitter binds to receptor (postsynaptic receptor) 7. Deactivation of
neurotransmitter
With respect to neurotransmitters, which of the following is a correct sequence?
In 1937, the primary motor cortex was mapped by electrically stimulating the
cortex of conscious human subjects who were undergoing neurosurgery. This was
accomplished by
Penfield and Boldrey
The primary motor cortex receives cutaneous feedback from only one part of the
body: the hands. This feedback likely plays an important role in
stereognosis
In the primary motor cortex, the neurons that participate in the movement of a
particular finger are
widely distributed over the somatotopic hand area
A study of the firing of primary motor cortex neurons while monkeys moved
freely about indicated that their firing was often related to the
It has been estimated that over half the neurons of the brain are in a structure
that constitutes only 10% of the brain's total mass. This structure is the
cerebellum
Recent fMRI studies have changed the traditional view of the cerebellum by
suggesting that in addition to its sensorimotor functions it is involved in
control and learning of cognitive responses
The _________receives information from various parts of the cortex and feeds
it back to motor cortex
basal ganglia
The _____is part of a loop including the cortex and the basal ganglia
thalamus
Signals from the left primary motor cortex descend through the spinal cord white
matter in one of
four major tracts
Only primates and a few other species, such as hamsters and raccoons, have
cortical neurons that synapse directly on
motor neurons that project to the muscles of the fingers and thumb
red nucleus
In general, the ventromedial descending motor tracts control the muscles of the
trunk
Monkeys could not move their fingers independently after transections of the
dorsolateral corticospinal tracts
In the transection experiments of Lawrence and Kuypers, monkeys with all their
dorsolateral motor pathways transected sat with their arms hanging limply by
their sides. However, these same monkeys had no difficulty
using their arms for standing, walking, and climbing
When a motor neuron fires, all of the muscle fibers of its motor
unit contract together
The motor units of the thumb, fingers, and face contain the
fewest muscle fibers
All of the motor neurons that innervate the fibers of a single muscle are called its
motor pool
Bob tried to open a jar of pickles, but the lid did not budge. The muscles of his
hands and arms were
in isometric contraction
Increases in muscle tension in the absence of any shortening of the muscle are
said to be
isometric
Intrafusal is to extrafusal as
muscle spindle is to skeletal muscle
During a stretch reflex, the extrafusal motor neuron is excited directly by the
spindle afferent neuron
The latency of withdrawal reflexes indicates that the fastest withdrawal reflex
neural circuit involves
2 synapses
If given the correct sensory feedback, the cat spinal cord is capable of controlling
walking movements
The results of the treadmill experiment by Grillner (1985) suggest that part of the
central sensorimotor program for walking is in the
spinal cord
The fact that the same basic movement can be carried out in different ways
involving different muscles is called
motor equivalence
One fMRI study indicated that the central sensorimotor programs for signing
one's name are stored in
secondary motor cortex
Response chunking and changing the level of control are thought to be important
processes in
sensorimotor learning
A major finding of the Jenkins and colleagues PET study of motor learning was
that the
contralateral primary motor and somatosensory cortexes were equally activated
during well-spiced and newly learned sequences
The process of the growth of a fertilized egg into a mature nervous system is
called
neurodevelopment
Embryonic cells that have the potential for unlimited renewal and have the
ability to develop into different kinds of mature cells if they are transplanted to
different sites are often called
embryonic stem cells
Immature cells that have the potential to develop into various kinds of mature
cells are called
multipotent cells
By 40 days after conception, three swellings become visible at the anterior end of
the human neural tube. The most anterior of these swellings eventually develops
into the
forebrain
By 40 days after conception, swellings are clearly visible at the anterior end of
the neural tube. There are
3
After the formation of the neural tube, the number of cells destined to become
part of the adult nervous system
increases rapidly
Most neural proliferation occurs in the layer of the neural tube that is adjacent to
the fluid-filled central canal
Research on the migration of future neocortical neurons has made one important
point: ______is everything.
timing
During the formation of the neural tube, a few cells break off from the neural
plate and form a structure that lies dorsal to the tube. This structure is the neural
crest
Frogs, unlike mammals, have retinal ganglion cells that are capable of
regeneration
In frogs, salamanders, and other simple vertebrates, retinal ganglion cells project
primarily to the
tectum
In Sperry's classic studies of eye rotation and regeneration of the optic nerves, he
assessed the visual capacities of his subjects by assessing their ability to
strike accurately at fly-like stimuli
The first growth cone of a developing tract to reach the target is called a
pioneer growth cone.
Only those growth cones that are not pioneer growth cones can normally find
their way to their targets by
fasciculation
If an optic nerve of a mature frog is transected and half of the associated retina is
destroyed,
the axons grow out from the remaining retinal ganglion cells to targets
systematically distributed over the entire optic tectum
Eyes and optic tectums grow at different rates. As they grow, the synaptic
connections that were originally formed on the tectum by axons of retinal ganglion
cells shift so that the retina is always fully and faithfully mapped on the tectum.
This finding supports the
topographic-gradient hypothesis
Less is known about synapse formation than axon growth because synapse
formation requires
coordinated activity in at least two cells
Neuron death
is a stage of normal early neural development
Most of the cell death associated with early development of the brain is
apoptotic
With a few exceptions, all of the neurons that will compose the adult human
brain have developed and are in their appropriate location by the
seventh month of prenatal development
The disruptive effects of total visual deprivation of the left eye on subsequent
vision through the left eye are greater when the
deprivation occurs early in life and right eye is not deprived at the same time
One eye only has to be totally deprived of stimulation for _____early in life in
order to produce significant reductions in the proportion of visual cortex neurons
that can be activated by stimulation of the deprived eye
a few days
Knudsen and Brainard (1991) raised barn owls with vision-displacing prisms
over their eyes. This led to the ontogenetic development of
a corresponding shift in the auditory topographic map in the tectum
Several studies have shown that early music training increases the size of the
auditory cortex that responds to complex musical tones.
The first evidence that new neurons can be created in the brains of adult animals
came in the early 1980s from the study of
songbirds
Studies have shown that about ______new neurons are created each hour in the
hippocampus of adults
2000
Adult stem cells that migrate to the olfactory bulbs are created at certain sites in
the
ependymal layer
Adult stem cells that become hippocampal neurons are created near the
hippocampus
The area of somatosensory cortex receiving input from the left hand was found to
be bigger in
musicians who finger stringed instruments with the left hand
Although they have many cognitive problems, Williams people have good
musical abilities and language abilities
striatum
Deterioration of the pathway from the substantia nigra to the striatum is often
found in cases of
Parkinson's disease
____ are multipolar cortical neurons with long axons, apical dendrites, and
triangular cell bodies
Pyramidal cell
Pyramidal cell
The _____ of the PNS only projects from the cranial and sacral portions of the
CNS
4 (FOUR)
axon
inferior
Parkinson's disease
L-DOPA
polarized
ions
Cl- ions
electrostatic pressure
Ions pass through the neural membrane via specialized pores called
ion channels
transporters
an IPSP
Hyperpolarization is to depolarization as
inhibitory is to excitatory
IPSP is to EPSP as
hyperpolarization is to depolarization
How far do most postsynaptic potentials travel before they die out?
"summation"
The end of the rising phase of an action potential occurs when the
The brief period of time immediately after the initiation of an action potential
when it is absolutely impossible to initiate another one in the same neuron is
called the
Neurons do not normally fire more than 1,000 times per second because
The fact that the intensity of stimulation is related to the rate of neural firing is
attributable to the
nondecremental
The conduction of an action potential along any axon is mediated by the action of
Conduction of APs from the axon into the cell body and dendrites of a multipolar
neuron is
antidromic
With respect to the maximum speed of axonal conduction in motor neurons, cats
are to humans as
Axodendritic synapses
vesicles
Golgi complexes
ribosomes
axoaxonic synapses
Neuropeptides are transported from the cell body to the buttons at a speed of
about
Many buttons contain two sizes of vesicles; the larger ones typically contain
neuropeptides
Many neurons contain and release two neurotransmitters. This situation is called
coexistence
exocytosis
binds to acetylcholine
postsynaptic neuron
presynaptic membranes
neurotransmitter
Autoreceptors
reuptake
acetylcholine
acetylcholinesterase
GABA
Glutamate
Monoamines
norepinephrine
Epinephrine
Catecholamines
tryptophan
epinephrine
a choline molecule
Acetylcholine is
_____is an endocannabinoid
Anandamide
Close to 100
agonists
Cerebral angiography
horizontal sections
_____ is not an adaptation of X-ray photography and provides the most detailed
three-dimensional view of the structure of the living human brain?
MRI
The reason why radioactive 2-DG is useful for revealing the level of activity of
neurons in different parts of the brain is that 2-DG
fMRI
...
neuropeptides
dopamine agonists
Cocaine and amphetamine in high doses can produce a disorder that is similar to
schizophrenia
are D2 blockers
Cerebral angiography
horizontal sections
_____ is not an adaptation of X-ray photography and provides the most detailed
three-dimensional view of the structure of the living human brain?
MRI
The reason why radioactive 2-DG is useful for revealing the level of activity of
neurons in different parts of the brain is that 2-DG
fMRI
MEG
---- is a method used by cognitive neuroscientists to turn off part of the brain
while the effects on cognition and behavior are assessed
TMS
causal relations
An electroencephalograph is
an EEG machine
the scalp
relaxed wakefulness
psychophysiologist
random signals
The main difference between an average evoked potential (AEP) and a "raw"
evoked potential is that
The P300
Components of AEPs recorded in the first few milliseconds after a stimulus are
electromyography
Electrooculography is
eye movement
4 (FOUR)
If you were startled by a loud noise, there would be an increase in your skin's
conductance of electricity. This response is called
Sweat glands
Hypertension is
Sphygmomanometers
Penile erection is
a plethysmographic response
stereotaxic surgery
The reference point for many stereotaxic atlases of the rat brain is
bregma
aspiration
_____ techniques are least likely to be associated with the destruction of major
blood vessels
Aspiration lesion
The ___ created by the current is the main cause of tissue damage produced be a
radio-frequency lesion.
heat
cryogenic blockage
unilateral lesions
Lesions restricted to structures in one half of the brain usually have effects that
are much less severe than comparable
bilateral lesions
Apraxia
is a disorder of voluntary movement that is not attributable to a simple motor deficit
or to any deficit in comprehension or motivation---apraxia is often cause by
unilateral damage to the left posterior parietal lobe or its connections.
Contralateral neglect
is a disturbance of a patient's ability to respond to stimuli on the side of the body
opposite (contralateral) to the side of the brain lesion, in the absence of simple
sensory or motor deficits. Have difficulty responding to things to the left.
----egocentric left----partially defined by gravitational coordinates.-----tend to not
respond to the left sides of objects, regardless where the object are in their visual
field.
It happens at the higher level of the brain (at the object level) posterior parietal lobe
integrates sensory information.
Premotor cortex
runs in a strip from the suplementary motor area to the lateral fissure.
Mirror neurons
Are neurons that fire when an individual performs a particular goal-directed hand
movement or when he or she observes the same goal-directed movement performed
by another.
-possible neural basis of social cognition (knowledge of others' mental processes
-likely to be found in humans
-indirect evidence from functional bain-imaging studies. they are called EMPATHY
neurons ejemplo; smile----response-- smile
-they have been found in the inferior portion of the posterior parietal lobe.---Autism
is a huge problem with mirror neurons.
somatotopic
layout of the human primary motor cortex is commonly referred to as the MOTOR
HOMUNCULUS (little man) more cortex devoted to body parts that make complex
movements----Somatosensory cortex mirror the motor cortex.
-until recently, each neuron was thought to encode the direction of movement.
stereognosis
the process of identifying objects by touch
astereognosia
damage to the primary motor cortex (deficits in stereonosis) may reduce the speed,
accuracy and force of a patient's movements. the larger the lesion the less movement
you will have.
CEREBELLUM
it constitutes only 10% of the mass of the brain and more than half of the brain
neurons.
-receives information from primary and secondary motor cortex, information about
descending motor signals from brain stem motor nuclei and feedback form motor
responses via the somatosensory and vestibular systems.
-involved in timing, and motor learning--may also do the same for cognitive
responses.
-output on the cerebellum is inhibitory--keeps muscles for firing each other. (trust
the cerebellum)
BASAL GANGLIA
do not contain as many neurons as the cerebellum, but in one sense they are more
complex---are a complex heterogeneous collection of interconnected nuclei.
-they are part of neural loops that receive cortical input form various cortical areas
and transmit it back to the cortex via the thalamus. Many of these loops carry signals
to and from the motor areas of the cortex.
-are thought to be involved in a variety of of cognitive functions, including learning,
in addition to their role in the modulation of motor output.
Two dorsolateral
one group of axons that descend from the primary motor cortex does so through the
medullary pyramids
DORSOLATERAL CORTICOSPINAL TRACT (direct)more notable among its
neurons are the BETZ CELLS- extremely large pyramidal neurons of the primary
motor cortex. 1st motor cells to die---(70-80 people start to shuffle)
they synapse on small neurons in the spinal gray matter, which synapses on the
motor neurons of distal muscles of the wrist hands, fingers, and toes,
-synapse in the red nucleus of the midbrain
DORSALLATERAL CORTICORUBROSPINAL TRACT (rubro refers to red nucleus)
(indirect) synapse at red nucleus and cross before the medulla
-some control the muscles of the face.
-synapse on interneurons that in turn synapse on motor neurons that project to the
distal muscles of the arms and legs.
.+
Two ventromedial
VENTROMEDIAL CORTICOSPINAL TRACT (direct)
CORTICO_BRAINSTEM_SPINAL TRACT (indierect)
Descend ipsilateral from the primary motor cortex directly into the ventromedial
areas of the spinal white matter.
-controls proximal muscles of the trunk and limbs.
tectum
which receives auditory and visual information about spatial location
vestibular nucleus
receives information about balance from receptor in the semicircular canals of the
inner ear
reticular formation
contains motor programs that regulates complex species-typical movements such as
walking, swimming and jumping.
motor end-plate
the release of acetylcholine by motor neurons at neuromuscular junctions activate
the motor-end plate on each muscle fiber and cause the fiber to contract.
motor pool
all of the motor neurons that innervate the fibers of a single muscle
muscle
muscle fiber bind together by a tendon
flexors
act to bend or flex a joint
extensors
act to straighten or extend it
synergistic muscles
any two muscles whose contraction produces the same movement, be it flexion or
extension.
antagonistic muscles
those like act in opposition like the biceps and triceps.
isometric contraction
activation of a muscle can increase the tension that it exerts on two bones without
shortening and pulling them together
dynamic contraction
it can shorten and pull them together.
neuroscience
The study of the nervous system is called:
memory
Jimmie G., the man frozen in time, had a severe problem with his
biopsychology
Psychobiology, behavioral biology, and behavioral neuroscience are all approximate
synonyms for:
D. O. Heeb
The man who played a key role in the emergence of biopsychology as a discipline by
writing "The Organization of Behavior" is:
comparative psychology
The division of biopsychology that studies the neural mechanisms of behavior
through the direct manipulation of the brains of laboratory animals in controlled
experiments is:
neuroscience
Biopsychology is a branch or division of
The brains and behavior of non-human subjects are simpler than those of human
subjects 2. Insights frequently arise from the comparative approach 3. It is
possible to conduct research of lab animals (ethical reasons)
An advantage of biopsychological research on nonhuman animals as opposed to
humans is that:
independent variable
In a well-designed experiment, there is only one systematic difference between the
conditions. This difference is manipulated by the experimenter and is called the:
the sexually frigid animal will often resume sexual activity if the current partner is
replaced with a new one (affected females)
The experiment of Lester and Gorzalka (1988) is significant because it constitutes
the first strong evidence of a Coolidge effect in:
applied research
Research that is intended to bring about direct benefit to humankind is:
Psychopharmacology
Which subdivision of biopsychology is most likely to be identified with an
experiment in which the effects of Prozac on the ability of mice to learn a maze is
studied?
Psychophysiology
cognition
A term that refers to higher intellectual processes such as thought, memory, and
attention is
converging operations
Scientific progress is most likely when different approaches are focused on a single
problem, particularly when the strengths of one approach compensate for the
weaknesses of the others. This is called:
traditional dichrotomies
A major purpose of Chapter 2 of Biopsychology is to teach you not to think about the
biology of behavior in terms of
Socrates
The idea that the human brain and human mind are separate entities was
formalized in the 1600s by
genetics is to experience
Nature is to nurture as
: a mirror
29One way to study self-awareness in nonhuman animals is to confront them with
vole
The conspecific of a vole is a
evolutionary psychology
The field that focuses on the evolution of human behavior is
in which each female could raise more fit young if she had a divided help
According to one prominent theory, monogamy evolved in only those species
phenotype
An organism's observable traits are referred to as its
doubles
Just prior to mitotic cell division, the number of chromosomes in the cell:
4
How many different nucleotide bases are there in DNA
20,000
How many structural (protein-coding) genes are there in the human genome?
Messenger RNA
RNA editing is an important epigenetic mechanism: It occurs when small RNA
molecules act directly on strands of:
selectively breeding so-called maze bright and maze dulls strains of rats
Tryon is famous for
Phenylketonuria
Which of the following disorders was discovered by Asbjrn Flling, a Norwegian
dentist?
false
People with phenylketonuria have a genetic disorder that inevitably leads to
disability
Minnesota Study
The most extensive study of twins reared apart is the:
True
It is now apparent that some genes can be turned on or off due to environmental
influence
among the very poor, the heritability estimate of IQ was close to 0 AND among the
affluent, the heritability estimate was close to 1
Pinel ended his discussion of the genetics of human psychological differences with a
description of the study of Turkheimer and colleagues (2003). The important
finding of this study was that:
carry sensory signals from the skin, sle;etal muscles, joints, eyes, ears, and so on to
the central nervous system
In general, afferent nerves carry sensory information (to or from where):
axon
What part of a neuron is sometimes myelinated?
multi-polar neuron
Neurons with one axon and several dendrites emanating from the soma are
classified as:
oligodendrocytes
In the CNS, axons are myelinated by:
microglia
The particular glial cells that engulf cellular debris and trigger inflammation are
golgi stain
The first neural stain revealed the silhouettes of a few neurons on a slide; it is:
determine the general distribution of cell bodies and the nervous system
Nissl stains (e.g., cresyl violet) are frequently used to:
dorsal
The top of a dog's head is (directional term)
dorsal surface
The spine of a human runs just beneath the body's (directional term)
medulla
The myelencephalon is often called the
?
Which of the following is not in the brain stem?
??
Which of the following is a large structure visible on the dorsal surface of the human
brain stem?
tactum
The inferior and superior colliculi compose the:
In the tegmentum are the periaqueductal gray, the substantia nigra, and the red
nucleus
Which structure is not part of the tegmentum?
diencephalon
The hypothalamus and thalamus compose the:
cortex
Most sensory nuclei of the thalamus project to the
Hypothalamus
Which structure of the diencephalon regulates the pituitary?
ipsilaterial
If a midsagittal cut were made through the human brain, all of the uncut axons
running from the eyes to the brain would be:
sulci
Big is to small as fissures are to:
central fissure
Between the frontal and parietal lobes is the:
telencephalon
The limbic system and basal ganglia are, for the most part, in the
limbic system
A neural circuit that includes the septum, cingulate cortex, fornix, amygdala,
hippocampus, hypothalamus, and thalamus is thought to be involved in the
regulation of motivated behaviors. This circuit is called the:
Parkinson's Disease
Deterioration of the pathway from the substantia nigra to the striatum is often found
in cases of:
Parkinson's disease
) Deterioration of the pathway from the substantia nigra to the striatum is often
found in cases of:
IPSP
A change in the resting potential of a postsynaptic dendrite from -70 mV to -72 mV
is called
inhibitory is to excitatory
Hyperpolarization is to depolarization as
the degree of depolarization on the axon adjacent to the hillock exceeds the
threshold of activation
A neuron normally fires when:
vesicles
Neurotransmitters are often stored in
ribosomes
Neuropeptides are synthesized in the cell body on
neuropeptides
Many buttons contain two sizes of vesicles; the larger ones typically contain:
exocytosis
The process of neurotransmitter release is referred to as:
reuptake
After release, most neurotransmitters are deactivated by
5 hydroxytryptamine
The abbreviation 5-HT stands for
epinephrine
Adrenergic neurons release
Agonist
Drugs that facilitate the activity of the synapses of a particular neurotransmitter are
said to be __________ of that neurotransmitter
dopamine agonists
Cocaine and amphetamines are:
What are the three main principles of sensorimotor function?
1. The sensorimotor system is hierarchically organized
2. Motor output is guided by sensory input
3. Learning changes the nature and locus of sensorimotor control
What are the only responses that are not influenced by sensory feedback?
ballistic movements: brief, all-or-none, high-speed movements
What three sensory systems does the posterior parietal association cortex receive
input from?
1. the visual system
2. the auditory system
3. the somatosensory system
Where does much of the output of the posterior parietal cortex go?
areas of the motor cortex, which are located in the frontal cortex: to the dorsolatoral
prefrontal association cortex, to the various areas of secondary motor cortex, and to
the frontal eye field
What kind of deficits can damage to the posterior parietal cortex produce?
Deficits in the perception and memory of spatial relationships, in accurate reaching
and grasping, in the control of eye movement and in attention
What are the two most striking consequences of posterior parietal cortex damage?
apraxia and contralateral neglect
What is apraxia?
Apraxia is a disorder of voluntary movement that is not attributable to a simple
motor deficit or to any deficit in comprehension or motivation
Most patients with contralateral neglect often behave as if the _____ side of their
world does not exist and fail to acknowledge that they have a problem
left
For most patients with contralateral neglect, the deficits in resonding occur for
stimuli to the left of their own bodies, referred to as ________
egocentric left
True or false: neurons that have egocentric receptive fields and others with objectbased receptive fields have been found in primate parietal cortex
True
What two types of evidence suggest that information about objects that are not
noticed by patients with contralateral neglect might be unconsciously perceived?
1. When objects were repeatedly presented at the same spot to the left of patients
with contralateral neglect, they tended to look to the same spot on future trials,
although they were unaware of the objects
2. Patients could readily identify fragmented (partial) drawings viewed to their right
if complete versions of the drawings had previously been presente to the left, where
they were not consciously perceived
What three areas does the dorsolateral prefrontal association corex send
projections to?
1. Primary motor cortex
2. Secondary motor cortex
3. Frontal eye field
True or false: there are neurons in all cortical motor areas that begin to fire in
anticipation of a motor activity, but those in the dorsolateral prefrontal cortex are
first
true
Areas of the secondary motor cortex receive much of their input from........... and
send much of their input to ..........
receive much of their input from association cortex (ie. posterior parietal cortex and
dorsolateral prefrontal cortex) and send much of their input to primary motor cortex
Which two areas of the secondary motor cortex were known for many years?
1. The supplementary motor area
2. premotor cortex
There are actually _____ areas of secondary motor cortex in each hemisphere
eight
What are the eight different areas in the secondary motor cortex?
Three different supplementary motor areas (SMA, preSMA, and supplementary eye
field), two premotor areas (dorsal and ventral(, and three small areas called the
cingulate motor areas.
Neurons in an area of secondary motor cortex often become more active just prior
to _____________
the intiation of a voluntary movement, and continue to be active throughout the
movement
What is the importance of finding mirror neurons in the venral premotor cortex?
They provide a possible mechanism ofr social cognition: knowledge of the
perceptions, ideas, and intentions of others
Monkeys have at least two different hand areas in the primary motor cortex of
each hemisphere, and one receives input from receptors in the skin rather than
from reeptors in the muscles and joints. What does this faclitate?
sterognosis
What is stereognosis?
The process of identifying objects by touch
True or false: There is a conventional view that many primary motor neurons are
tuned to movement in a particular direction
True
In alternate studies, it was found that the firing of many primary motor cortex
neurons is most closely related to the _______ of a movemement, not to the
direction of the movemetn
endpoint
What are two important sensorimotor structures that help cordinate and module
motor activity?
the cerebellum and basal ganglia
The basal ganglia are involved in reward circuity as well as, in newer models,
cognition (in addition to their role in the modulation of motor output)
...
What is the fact that the same basic movement can be carried out in different ways
involving different muscles called?
motor equivalence
What are two important processes that influence the learning of central
sensorimotor pathways?
1. response chunking
2. shifting control to lower levels of the sensorimotor sstem
What are the two advantages of shifting the level of ccontrol to lower levels of the
sensorimotor system?
1. It frees up the higher levels of the system to deal with more esoteric aspects of
performance
2. It permits great speed because different circuits at the lower levels of the
hierarchy can act simultaneously, without interfering with one another