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Lymph Node
i. Blood Artery capillaries Vein at hilum of the LN
ii. Lymph Afferent lymphatics branch at subcapsular space
cortical sinuses medullary sinuses efferent lymphatics (see
lots of lymphocytes in efferent lymphatic) thoracic duct
1. subcapsular sinus: thin walled endothelial cells deep to
capsule, mostly clear and w/o cells, but has some
macrophages/dendritic cells
iii. Lymph fluid: acellular mostly w/ few inflam cells with antigns for
IC presentation
2. LN architecture disrupted in malignancy
3. Follicular structures
i. Germinal Center (Inside) Mantle zone Marginal zone
(spleen)
ii. Nave B cells enter at mantle zone antigen presentation
migrate to germinal center proliferate/somatic hypermutation
migrate to marginal zone or blood (blood for LN)
4. Germinal center
i. Normal reactive, non-neoplastic germinal center: Polarized
ii. Light zone: smaller, less proliferative cells w/ less antigen
stimulation, Centrocytes
iii. Dark zone: larger cells w/ dispersed, delicate chromatin,
moreblastlike, more proliferation, Centroblasts (2-3x larger than
centrocytes), blastoid chromatin pattern)
5. Reactive lymph node follicles
i. Tingible body macrophages:
1. Macros with debris in cytoplasm present at areas of cell
turnover/proliferation in reactive LNs
ii. Follicular dendritic cell
1. stromal element of a LN, form framework for a LN
6. Paracotex
i. T cell dominant, vascular