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Anonymous. Ophthalmology Times. Cleveland: Jun 15, 2007. Vol. 32, Iss. 12; pg. 42, 1
pgs
Abstract (Summary)
Extended UV exposure has been linked to eye damage, including cataract, age-related
macular degeneration, pterygium, and photokeratitis.
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Full Text
(215 words)
Copyright Advanstar Communications, Inc. Jun 15, 2007
Pterygium (conjunctiva)
From Wikipedia, the free encyclopedia
Pterygium (conjunctiva)
Classification and external resources
ICD-10 H11.0
ICD-9 372.4
DiseasesDB 10916
MedlinePlus 001011
eMedicine oph/542
MeSH D011625
Contents
[hide]
• 1 Pathology
• 2 Prevention
• 3 Symptoms
• 4 Treatment
• 5 See also
• 6 References
• 7 External links
[edit] Pathology
[edit] Prevention
As it is associated with excessive sun or wind exposure, wearing protective sunglasses
with side shields and/or wide brimmed hats and using artificial tears throughout the day
may help prevent their formation or stop further growth. Surfers and other water-sport
athletes should wear eye protection that block 100% of the UV rays from the water, as is
often used by snow-sport athletes.
[edit] Symptoms
Symptoms of pterygium include persistent redness, inflammation, foreign body sensation,
dry and itchy eyes. In advanced cases the pterygium can affect vision as it invades the
cornea with the potential of obscuring the optical center of the cornea and inducing
astigmatism and corneal scarring.[4][5]
[edit] Treatment
Today a variety of options are available for the management of pterygium, from
irradiation, to conjunctival auto-grafting or amniotic membrane transplantation, along
with glue and suture application. As it is a benign growth, pterygium typically does not
require surgery unless it grows to such an extent that it covers the pupil, obstructing
vision or presents with acute symptoms. Some of the irritating symptoms can be
addressed with artificial tears. However, no reliable medical treatment exists to reduce or
even prevent pterygium progression. Definitive treatment is achieved only by surgical
removal. Long-term follow up is required as pterygium may recur even after complete
surgical correction.
If there is recurrence after surgery or if recurrence of pterygium is thought to be vision
threatening, it is possible to use strontium (90Sr) plaque therapy. 90Sr is a radioactive
substance that produces beta particles which penetrate a very short distance into the
cornea at the site of the operation. It suppresses the regrowth of blood vessels that occur
with return of the pterygium. The treatment requires some local anaesthetic in the eye and
is best done at the time of, or on the same day as the pterygium excision.
The 90Sr plaque is a concave metal disc about 1-1.5cm in diameter which is hollow and
filled with an insoluble strontium salt. The side placed on the eye is a very thin and
delicate silver film that will contain the strontium but allow the beta particles to escape.
The dose of radiation to the conjunctiva is controlled by the time that the plaque is left in
contact with the surface. The integrity of the plaque surfaces is paramount to prevent
exposure to patients and so is wipe tested to see if radioactive matter is escaping.
Obviously this test must be done very very gently.
Conjunctival auto-grafting is a surgical technique that is effective and safe procedure for
pterygium removal. When the pterygium is removed the tissue that covers the sclera
known as the conjunctiva is also extracted, auto-grafting replaces the bare sclera with
tissue that is surgically removed from the inside of the patients’ upper eyelid. That “self-
tissue” is then transplanted to the bare sclera and is fixated using sutures, tissue adhesive,
or glue adhesive.
Amniotic membrane transplantation is an effective and safe procedure for pterygium
removal. Amniotic membrane transplantation offers practical alternative to conjunctival
auto graft transplantation for extensive pterygium removal. Amniotic membrane
transplantation is tissue that is acquired from the innermost layer of the human placenta
and has been used to replace and heal damaged mucosal surfaces including successful
reconstruction of the ocular surface. It has been used as a surgical material since the
1940s, and has been shown to have a strong anti-adhesive effect. [6] [7] Using an amniotic
graft facilitates epithelialization, and has anti-inflammatory as well as surface
rejuvenation properties. Amniotic membrane transplantation can also be fixated to the
sclera using sutures, or glue adhesive.[8] [9] [10] [11] [12] Amniotic membrane transplantation
with Tisseel glue application and Mitomycin-C has shown excellent cosmetic outcomes
with a surface free of redness, stitching, or patches which makes the ocular surface
suitable for vision correction surgery sooner.[13] [14] [15]
Full Text
(2697 words)
Copyright Slack, Incorporated Nov/Dec 2001
[Headnote]
* BACKGROUND AND OBJECTIVE: To assess the outcome of simple excision with
preserved human amniotic membrane transplantation in the treatment of primary
pterygium.
m PATIENTS AND METHODS: A total of 59 eyes with primary pterygium underwent
surgical excision. In Group 1, 28 eyes were treated with simple excision and preserved
human amniotic membrane transplantation. In Group 2, 31 eyes were treated with bare
sclera excision. These two groups were compared in recurrence, final appearance of the
operation site, and complications. Patients were followed for at least 10 months.
[Headnote]
* RESULTS: During a mean follow up of 14.9 months, we observed 3 (10.7%)
recurrences in Group 1 and 20 (38.7%) recurrences in Group 2 (P:0.03). In Group 1, 20
(71.4%) eyes and 14 (45.2%) eyes in Group 2 had a satisfactory final operation site
appearance (P:0.041). No serious complication was observed in both groups.
0 CONCLUSION: Simple excision and preserved human amniotic membrane
transplantation appears to be a safe and effective way of treating primary pterygium
because of the lack of serious complications and a relatively low rate of recurrence.
[Ophthalmic Surg Lasers 2001;32:464-4691
Table 1.
DISCUSSION The main goal of treatment for eyes with pterygium is to achieve a
permanently healthy and cosmetically acceptable ocular surface without recurrence of
pterygium.2' However, recurrence could not totally be prevented despite various surgical
techniques and adjunctive treatments (Table 3). Even some treatment modalities may be
fraught with serious sight-threatening complications such as scleral ulceration,
scleromalacia and corneal perforation.'- Conjunctival autografting following surgical
excision of the pterygium seems to achieve promising surgical outcomes with low
recurrence rates and without serious complications.1,15-19 However, this technique
sacrifices the remaining healthy conjunctiva that may be vital for further eye procedures.
Thus, amniotic membrane grafting may be a viable option.
The use of amniotic membrane in ophthalmology was first reported by de Rotth22 in
1979. In this study, live amniotic membrane, which also included chorion, was used in
the surgical treatment of symblepharon in 6 patients. Despite the initial successful
anatomic appearance, all membranes, except one, dissolved and disapeared in a very
short time. Although not proven histologically, their poor outcome might be attributed to
the use of live rather than a preserved amniotic membrane and/or the presence of chorion
in the transplanted tissue, leading to subsequent allograft rejection. In 1995, Kim and
Tseng23 reintroduced the use of amniotic membrane that was separated from the chorion,
processed, and then preserved. Results of later studies using preserved membrane in a
variety of ocular disorders are encouraging.15,20,23-28 In these studies, the risk of any
adverse effect, such as allograft rejection, was avoided by using a substrate without live
cells. Amniotic membrane seems to have a beneficial effect in promoting healthy and
rapid wound healing in the treatment of pterygia, conjunctival lesions and scars,
symblepharon, persistent corneal epithelial defects with ulceration, deep corneal ulcers,
chemical and thermal burns, ocular cicatricial pemphigoid, and Stevens-Johnson
syndrome.15,20,23-28 Besides, the reconstructed surface shows reduced inflammation
and reduced scarring.20,28 Interestingly, Lee and Tseng25 reported dissolution of the
membrane in 5 of 11 eyes following preserved amniotic membrane grafting for the
treatment of persistent epithelial defects with ulceration.15 Except for one, epithelization
lasted in all other patients. Growth factors that are present in the preserved amniotic
membrane might be liberated following dissolution and have stimulated healthy wound
healing.29 In our series, we observed dissolution of the membrane in 3 eyes, 3 to 5 weeks
following grafting. In the long-term follow up, only 1 of these 3 eyes experienced
recurrence. The absence of recurrence in the other 2 eyes led us to think the possibility of
an ongoing beneficial effect after dissolution. Spontaneous dissolution phenomenon
should be the subject of other prospective studies focusing on ultrastructural examination.
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Table 2.
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[Photograph]
Figure 1.
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[Photograph]
Figure 2.
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Table 3.
In the current study, amniotic membrane grafting following simple excision of primary
pterygium resulted in a 10.7% probability of recurrence, compared with 38.7% for bare
sclera excision. The great variations in recurrence rates, even among different studies
using the same surgical procedure, can be explained by demographic differences and
variations of the same surgical technique. Our two groups shared similar characteristics
that enabled us to make a healthier comparision among the two distinct surgical
techniques (Table 1). Also, as all surgeries were performed by a single surgeon, the
amount of subconjunctival tissue removal and extent of cauterization were virtually alike.
In a similar study, there was a 10.9% recurrence rate following amniotic membrane
grafting with simple excision of primary pterygium.15 This result is similar to our rate
because surgical technique, preservation method, and processing of amniotic membrane
were alike.
Besides recurrence rate, operated eyes were also graded according to the final appearance
of the operation site. Satisfactory final appearance (grade 1) was present in 71.4% of eyes
in the amniotic membrane group, which was significantly higher than the 45.2% of the
bare sclera group. This finding seems to support previous speculations about the role of
the amniotic membrane in promoting healthy epithelial wound healing with reduced
inflammation and scarring. 15,20,23-28
In the two studies using preserved amniotic membrane for treating pterygia (current
studyl5), except for minor complications, no sight-threatening complication developed
(Table 2). Although being effective in preventing recurrence of pterygium, treatment with
mitomycin C, beta irradiation, and thiotepa may result in serious complications like
uveitis, secondary glaucoma, cataract, scleral ulceration and necrosis, scleromalacia,
corneal ulceration, corneal melting and perforation, bacterial corneoscleritis, fungal
panophthalmitis, bacterial corneoscleritis, and skin depigmentation.1-7,11 In this aspect,
amniotic membrane grafting seems to achieve relatively low recurrence rates, without
injuring otherwise healthy eyes.
Because of the latest preservation techniques, amniotic membrane transplantation is
feasible anytime necessary. Besides the efficiency in preventing frank recurrence,
amniotic membrane grafting following simple excision appears to be an easy, safe,
cosmetically satisfying, and efficient way of treating pterygium without jeopardizing the
remaining healthy conjunctiva and the eye.
[Reference]
REFERENCE
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[Reference]
1. Waller SG, Adamis AP Pterygium. In: Parks MM, Mitchell PR, eds. Duane's
Ophthalmology (on CDROM). Philadelphia: J.B. Lippincott; 1995: vol 6, chap 35.
2. Adamis AP, Starck T, Kenyon KR. The management of pterygium. Ophthalmol Clin
North Am. 1990;3:611 623.
3. Farrell PLR, Smith RE. Bacterial corneoscleritis complicating pterygium excision. Am
J Ophthalmol. 1989;107:515-517.
4. Ewing-Chow DA, Romanchuk KG, Gilmour GR, Underhill JH, Climenhaga DB.
Corneal melting after pterygium removal followed by topical mitomycin C therapy. Can J
Ophthalmol. 1992;27:197-199.
5. Rubinfeld RS, Pfister RR, Stein RM, Foster CS, Martin NF, et al. Serious
complications of topical mitomycin-C after pterygium surgery. Ophthalmology.
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[Reference]
6. Gupta S, Basti S. Corneoscleral, ciliary body, and vitreoretinal toxicity after excessive
instillation of mitomycin C. Am J Ophthalmol 1992;114:503-504.
7. Tarr KH, Constable IJ. Late complications of pterygium treatment. BrJ Ophthalmol
1980;64:496-505.
8. Aswad MI, Baum J. Optimal time for postoperative irradiation of pterygia.
Ophthalmology. 1987;94:14501451.
9. Nowell JE Management of pterygia 20 years later. South MedJ 1986;79:1382-1384.
10. de Keizer RJW, Swart-van den Berg M, Baartse WJ. Results of pterygium excision
with Sr 90 irradiation, lamellar keratoplasty, and conjunctival flaps. Doc Ophthalmol.
1987;67:33-44.
11. MacKenzie FD, Hirst LW, Kynaston B, Bain C.
[Reference]
Recurrence rate and complications after beta irradiation for pterygia. Ophthalmology.
1991;98:1776-1781.
12. Nakamura K, Bissen-Miyajima H, Shimmura S, Tsubota KI Clinical application of
Er:YAG laser for the treatment of pterygium. Ophthalmic Surg Lasers. 2000;31:8-12.
13. Forster W, Atzler U, Ratkay I, Busse H. Therapeutic use of the 193-nm excimer laser
in corneal pathologies. Graefes Arch Clin Exp Ophthalmol. 1997;235:296-305. 14. Krag
S, Ehlers N. Excimer laser treatment of pterygium. Acta Ophthalmol 1992;70:530-533.
15. Prabhasawat P, Barton K, Burkett G, Tseng SCG. Comparison of conjunctival
autografts, amniotic membrane grafts, and primary closure for pterygium excision.
Ophthalmology. 1997;104:974-985.
16. Tan DTH, Chee SP, Dear KBG, Lim ASM. Effect of pterygium morphology on
pterygium recurrence in a controlled trial comparing conjunctival autografting with bare
sclera excision. Arch Ophthalmol. 1997;115:1235-1240.
[Reference]
17. Kenyon KR, Wagoner MD, Hettinger ME. Conjunctival autograft transplantation for
advanced and recurrent pterygium. Ophthalmology. 1985;92: 1461-1470.
18. Riordan-Eva P, Kielhorn I, Ficker LA, Steele ADM, Kirkness CM. Conjunctival
autografting in the surgical management of pterygium. Eye. 1993;7:634-638.
19. Starck T, Kenyon KR, Serrano E Conjunctival autograft for primary and recurrent
pterygia: surgical technique and problem management. Cornea. 1991;10: 196-202.
20. Shimazaki J, Shinozaki N, Tsubota K. Transplantation of amniotic membrane and
limbal autograft for patients with recurrent pterygium associated with symblepharon. BrJ
Ophthalmol. 1998;82:235-240.
21. Hirst LW, Sebban A, Chant D. Pterygium recurrence time. Ophthalmology.
1994;101:755-758.
22. Treflford JD, Trelford-Sauder M. The amnion in surgery, past and present. Am J
Obstet Gynecol. 1979;134:833-845.
23. Kim JC, Tseng SCG. Transplantation of preserved human amniotic membrane for
surface reconstruction in severely damaged rabbit corneas. Cornea. 1995;
[Reference]
14:473-484.
24. Tseng SCG, Prabhasawat P, Lee S. Amniotic mem
brane transplantation for conjunctival surface reconstruction. Am J Ophthalmol. 1997;
124:765-774.
25. Lee SH, Tseng SCG. Amniotic membrane transplantation for persistent epithelial
defects with ulceration. Am J Ophthalmol. 1997;123:303-312.
26. Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular
surface reconstruction in patients with chemical and thermal burns. Ophthalmology.
1997;104:2068-2076.
27. Tsubota K, Satake Y, Ohyama M, Toda I, Takano Y, et al. Surgical reconstruction of
the ocular surface in advanced ocular cicatricial pemphigoid and StevensJohnson
syndrome. Am J Ophthalmol. 1996;122:3852.
28. Kruse FE, Rohrschneider K, Volcker HE. Multilayer amniotic membrane
transplantation for reconstruction of deep corneal ulcers. Ophthalmology. 1999;106:
1504-1510.
[Reference]
29. Koizumi NJ, Inatomi TJ, Sotozono CJ, Fullwood NJ, Quantock AJ, et al. Growth
factor mRNA and protein in preserved human amniotic membrane. Curr Eye Res.
2000;20:173-177.
30. Singh G, Wilson MR, Foster CS. Mitomycin eye drops as treatment for pterygium.
Ophthalmology. 1988;95: 813-820.
31. Cardillo JA, Alves MR, Ambrosio LE, Poterio MB, Jose NK. Single intraoperative
application versus postoperative mitomycin C eye drops in pterygium surgery.
Ophthalmology. 1995;102:1949-1952.
32. Manning CA, Kloess PM, Diaz MD, Yee RW. Intraoperative mitomycin in primary
pterygium excision. Ophthalmology. 1997;104:844-848.
33. Chen PP, Ariyasu RG, Daza V, LaBree LD, McDonnell PJ. A randomized trial
comparing mitomycin C and conjunctival autograft after excision of primary pterygium.
Am J Ophthalmol. 1995;120:151-160.
34. Ngoy D, Kayembe L. Comparative study of mitomycin C and thio-tepa in the
treatment of pterygium. Preliminary study. JFr Ophthalmol. 1998;21:96-102.
35. Krag S, Ehlers N. Excimer laser treatment of pterygium. Acta Ophthalmol.
1992;70:530-533.
[Author Affiliation]
Nalan Fatma Tekin, MD; Suleyman Kaynak, MD; Ali Osman Saatci, MD; Guray Cingil,
MD
[Author Affiliation]
From the Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
[Author Affiliation]
Accepted for publication April 9, 2001.
Address reprint requests to Suleyman Kaynak, MD, Retina Goz Hastaliklari Arastirma ve
Tedavi Merkezi, 1388 sok. No:16/A, 35220 Alsancak, Turkey [email:
retina@doctormail.com].
Full Text
(580 words)
Copyright Advanstar Communications, Inc. Apr 1, 1999
Figure 2
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(905 words)
Copyright Advanstar Communications, Inc. Jul 15, 2005
[Headnote]
Viable alternative
[Headnote]
Increased patient comfort, OR time savings help to offset cost of adhesive
[Photograph]
Dr. Hovanesian
In the first study, statistically significant differences favored fibrin tissue adhesive over
sutures for shorter operative time (13 versus 21 minutes, respectively) and for lessening
pain after surgery. While patients in 38% of sutured cases rated their pain as moderate to
severe, only 4% of cases performed with the fibrin adhesive were associated with that
level of pain. In addition, the proportion of cases associated with no pain was nearly two-
fold greater in the fibrin tissue adhesive group versus in the eyes with sutures, 41%
versus 23%, respectively.
Graft survival
In the longer-term study, all grafts survived and there were no pterygium recurrences,
defined as a >1-mm regrowth or need for reoperation. One graft developed a 1-mm
diameter area of central necrosis. However, it spontaneously re-epithelialized within 2
weeks when managed with lubrication and topical treatment with a steroid and antibiotic
and had done well at last follow-up at 6 months.
"Pterygium surgery is frequently combined with use of a conjunctival-limbal autograft
because that technique is associated with a low rate of recurrence. Unfortunately, sutures
used to fix the graft can cause significant postoperative inflammation," said Dr.
Hovanesian, clinical instructor, Jules Stein Eye Institute, UCLA, Los Angeles.
"The fibrin tissue adhesive costs about $75 for one dose. However, its use seems to have
no adverse impact on recurrence rate, and its benefits of OR time savings and increased
patient comfort offset its higher cost relative to sutures," he added.
Attention to technique
Dr. Hovanesian's technique for the surgery begins with a standard excision of the
pterygium from the cornea and conjunctiva, taking no more than a 1-mm margin of
normal conjunctiva. Then, a thin conjunctival autograft is taken from the superior limbus
region using careful dissection to ensure an adequate complement of limbal stem cells is
harvested while leaving Tenon's fascia in place as much as possible.
"This technique ensures a good cosmetic result in the graft and causes minimal scarring
of the superior conjunctiva so that it is preserved if glaucoma surgery becomes necessary
in the future," Dr. Hovanesian said.
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Figure 1 The superior limbal conjunctival autograft is dissected free from Tenon's fascia,
and dissection is performed into the clear cornea to obtain limbal stem cells (blue line).
Figure 2 Once freed from the limbus, the autograft includes stem cells.
Figure 3 A drop of thrombin solution and a drop of fibrinogen sealant are placed on the
scieral bed and the conjunctiva! autograft, respectively. (Figures courtesy of John A.
Hovanesian, MD)
The harvested graft is inverted to lay epithelium against corneal epithelium, cut free with
Vannas scissors, and moved in a limbus-to-limbus configuration near the bare sciera site.
The two components of the fibrin tissue adhesive are mixed on the eye in three steps by:
* placing a drop of the watery thrombin solution on the dry, bare sciera;
* placing a sparing amount (less than 1 drop) of the more viscous sealer protein solution
(fibrinogen/aprotinin) on the stromal side of the conjunctival autograft; and
* inverting the graft onto the sciera using forceps.
The graft is then positioned, keeping its limbal edge aligned with the corneoscleral
junction, and smoothed using forceps to achieve good edge alignment.
"The surgeon has only 10 to 15 seconds to position the graft appropriately before the
mixture congeals, so it is important to move quickly," Dr. Hovanesian said.
The fibrin tissue adhesive secures the graft well for 7 to 10 days, which allows adequate
time for healing. Postoperative care consists of overnight patching over ointment with
four-times-daily administration of prednisolone acetate 1% and a fluoroquinolone
antibiotic.
Fibrin glue was first developed for use in neurologic, cardiac, and abdominal surgery. Its
use in ophthalmic surgery is off-label, although there is a growing list of publications
reporting its value in various applications, noted Dr. Hovanesian.
Although the components of the fibrin tissue adhesive are derived from pooled human
and bovine blood, it has been used internationally for more than 25 years in
approximately 8 million surgeries with no documented cases of transmission of hepatitis
B or C, HIV, bovine spongiform encephalopathy, or prion-mediated disease.
FYI
John A. Hovanesian, MD
Phone: 949/951-2020
Fax: 949/951-9244
E-mail:jhovanesian@harvardeye.com
Dr. Hovanesian has no financial interest in Tisseel VH or Baxter Healthcare.
[Sidebar]
Take-Home Message
A retrospective review of 98 eyes undergoing pterygium surgery with fibrin tissue
adhesive (Tisseel VH Fibrin Sealant, Baxter BioSurgery) to secure a conjunctival-limbal
autograft demonstrates the adhesive is a safe alternative to sutures. It compares favorably
with respect to recurrence risk, and has advantages for minimizing surgical time and
postoperative pain.