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ACUTE RENAL FAILURE

(PATHOPHYSIOLOGY)

Decrease renal blood flow


Primary kidney diseases
Urine outflow obstruction

Necrosis of nephrons

Increase BUN decreaseGFR Fluid retention ECF Intravascular Increase vessel


Increase creatinine pressure permeability
(HPN)
Further loss of
Protein plasma
nephrons function
leaks into
interstitial space
Impaired kidney function

Edema

Loss of non-excretory renal function Loss of excretory renal function

Disturbances in Immune Impaired insulin Increase hydrogen Decrease Decrease


reproduction disturbance action excretion phosphate excretion of K
excretion
Decrease libido, Delayed wound Erratic Metabolic acidosis Hyperkalemia
infertility healing infection glucose levels Hyperphosphatemia
Excretion of
Increase Failure to Decrease calcium
Failure to convert nitrogenous waste
production of produce absorption
inactive forms of calcium
lipids erythropoietin
Uremia
Hypocalcemia
decreaseCa absorption
anemia
Advanced
Bleeding tendencies
atheresclerosis
Hypocalcemia Pallor

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