Mechanical intestinal obstruction secondary to rectal tumor = Gender Age Status Modifiable Non-modifiable + Lifestyle diet smoking stress Multiple consecutive giving birth w/ interval of only month Repeated trauma into a tissue Interfere tissue function exposure of normal cell to carcinogens alteration to the normal function of cell repeated exposure to carcinogens promotion the activation of oncogenes where in these are mutant genes that causes the transformation of normal cell into tumor cell (Laan that causes the Sansfonmast mutant RAS, protein stimulates cell growth of tumor there will be formation of new blood vessels regulated by growth tumor factor As cell grow high glucose oxygen and estrogen are needed by tumor affection to the hypothalamus and pituitary gland decrease supply of nutrients and oxygen to the other parts failure of the immune response inability to destroy antigensprogress growth tumor MECHANICAL OBSTRUCTION y r + Gases and fluids accumulate Bacterial activity Borborygmi | ven pq inthe area [ Inc contractions of Distension of intestine proximal intestine ¥ Persistent vomiting Increase intraluminal pressure Severe colicky | abdominal v pain + Loss of hydrogen ions, Increase secretions into the potassium intestine I + ib¢ Compression of veins Metabolic alkalosis : Decrease absorption| + Edema of the intestine oe Dec arterial blood supply ¥ Ischemia, Anoxia ¥ ¥ Gangrenous intestinal wall ¥ Cessation of peristalsis Compression of terminal branches of mesenteric artery Necrosis = —_ Perforation of necrotic segments [+ Bacteria or toxins leak into: —— Peritoneal cavity Blood supply ¥ Bacteremia Peritonitis, Septicemia