PATHOPHYSIOLOGY OF MENINGIOMA Non modifiable risk factors: y y y y y Gender (female)70% Age (above 50 up to 80 yrs old) Hereditity (nervous system

disorders: neurofibromastosis type 2) Monosomy of chromosome 22 (70-80%) Female hormones Modifiable risk factors: y y y y Exposure to ionizing radiation Previous head trauma Cellphone use virus

Increase number and growth of normal meningothelial cells.

presence of encapsulated tumors Increase ICP is less common

Benign tumor

Slow growth

Arise from the arachnoid cap cells penetration in the inner dura at the venous sinuses

formation of mass Growth through the holes at the base of the skull or outside the skull Attachment to the dura size adapts to the shape it occupies

Invasion at the bones

Increase growth and size

May extend to the dural space

Erosion of cranial bone

Leads to localized thickening

Compresses the optic nerve

Hyperostosis Vision changes

Indentation in the brain parenchyma or other neurovascular structures Increase ICP

Production of osteoblastic reaction

Lesion seen on CT

Focal seizures

Headache

NEXT PAGE

Benign tumor formation in the occipital area

Craniotomy

Tissue trauma

Open wound

Disruption of cell membrane Risk for infection Starts of inflammatory process

Nociceptors on the dermis

Impaired tissue integrity

Send impulse to central nervous system Pain on surgical site

Release of prostaglandin and bradykinin

Activity intolerance