PARENT ERALS

PARENTERAL ROUTES OF ADMINISTRATION SUBCUTANEOUS ROUTE

SMALL AMOUNT OF MEDICATION INJECTION OF DRUG MADE THROUGH USUALLY IN THE LOOSE INTERSTITIAL TISSUE OUTER UPPER ARM ANTERIOR THIGH LOWER ABDOMEN 1.3 mL > 2 mL CAUSE PAINFUL PRESSURE SYRINGES 3 mL CAPACITIES AND 24-26 GAUGE NEEDLES ARE USED IRRITATING DRUGS NOT SUITABLE FOR SC INJECTION

SUBCUTANEOUS ROUTE

EXAMPLE: INSULIN INJECTIO N

PARENTERAL ROUTES OF ADMINISTRATION

INTRADERMAL ROUTE
INJECTED INTO THE CORIUM DIAGNOSTICS DETERMINATIONS, DESENSITIZATION, OR IMMUNIZATION. USUAL SITE FOR ID INJECTION IS THE ANTERIOR FOREARM NEEDLE IS INSERTED HORIZONTALLY INTO THE SKIN .1 mL USUALLY ADMINISTERED

INTRADERMAL ROUTE
ID INJECTIO N OF IMMUNIZ ATON SUBSTA NCE

OFFICIAL TYPES OF INJECTION

OFFICIAL TYPES OF INJECTION

INJECTION:
LIQUID THAT ARE DRUG SUBSTANCES OR SOLUTIONS
EG. INSULIN INJ. USP

OFFICIAL TYPES OF INJECTION

FOR INJECTION:
DRY SOLIDS + SUITABLE VEHICLE = SOLUTIONS CORFORMING REQUIREMENTS FOR INJECTION

EG. CEFUROXIME FOR INJ, USP

OFFICIAL TYPES OF INJECTION

INJECTABLE EMULSION
LIQUID PREPARATION > DISSOLVED IN SUITABLE EMULSION MEDIUM
EG. PROPOFOL,USP

OFFICIAL TYPES OF INJECTION

INJECTABLE SUSPENSION
LIQUID PREPARATION OF SOLID SUSPENDED IN A SUITABLE LIQUID MEDIUM
EG. METHYLPREDNISOLONE ACETATE SUSPENSION, USP

OFFICIAL TYPES OF INJECTION

FOR INJECTABLE SUSPENSION
DRY SOLID + SUITABLE VEHICLE = PREP. CONFORMING REQ. FOR INJECTABLE SUSPENSIONS
EG. IMIPENEM AND CILASTATIN FOR INJECTABLE SUSPENSION, USP

DIFFERENCES BETWEEN PARENTERALS AND OTHER DOSAGE FORM

DIFFERENCES BETWEEN PARENTERALS AND OTHER DOSAGE FORM SOLVENTS OR VEHICLE MUST MEET

SPECIAL PURITY USE OF ADDED SUBSTANCES FALLS UNDER SPECIFIC GUIDELINES OF USE AND RESTRICTED IN CERTAIN PARENTERAL PRODUCTS. USE OF COLORING AGENTS IS STRICTLY PROHITED SHOULD MEET STERILITY STANDARDS AND MUST BE PYROGEN LIMITED MUST MEET COMPENDIAL STANDARDS FOR

DIFFERENCES BETWEEN PARENTERALS AND OTHER DOSAGE FORM EACH CONTAINER OF AN INJECTION
IS FILLED TO VOLUME IN SLIGHT EXCESS OF THE LABELED TO BE WITHDRAWN. VOLUME OF INJECTION PERMITTED IN MULTIPLE CONTAINERS ARE RESTRICTED AS ARE TYPES OF CONTAINERS THAT MAY BE USED FOR CERTAIN INJECTIONS. SPECIFIC LABELING REGULATIONS APPLY TO INJECTIONS

SOLVENTS AND VEHICLES FOR INJECTIONS

 PURIFIED WATER, USP

SOLVENTS AND VEHICLES FOR INJECTIONS

NMT 1 mg/100 mL WATER FOR INJECTION MUST BE PYROGEN FREE INTENDED FOR MANUFACTURING INJECTABLE PRODUCTS TO BE STERILIZED AFTER PREPARATIONS STORED IN TIGHT CONTAINERS SHOULD BE USED WITHIN 24 HOURS AFTER COLLECTION CONTAINERS ARE USUALLY GLASS OR GLASS LINED

SOLVENTS AND VEHICLES FOR INJECTIONS STERILE WATER FOR INJECTION, USP

PACKAGED IN SINGLE DOSE NLT 1L PYROGEN FREE AND NMT .25 USP ENDOTOXIN / Ml NO ANTIMICROBIAL AGENT OR OTHER ADDED SUBSTANCE INTENDED TO BE USED AS A SOLVENT, VEHICLE OR DILUENT 1L BOTTLES CANNOT BE ADMINISTERED IV
USED AS RECONSTITUTION OF MULTIPLE ANTIBIOTICS

SOLVENTS AND VEHICLES FOR INJECTIONS

BACTERIOSTATIC WATER FOR INJECTION
STERILE WATER + ANTIMICROBIAL AGENTS PACKAGED IN PREFILLED SYRINGES NMT 30ml LABEL(NAME, PROPORTIONS OF AGENTS) PRESENCE OF BACTERIOSTATIC AGENT GIVES THE FLEXIBILITY FOR MULTIPLE VIALS BEC. OF THE PERESENCE OF

SOLVENTS AND VEHICLES FOR INJECTIONS

BACTERIOSTATIC WATER FOR INJECTION
USP REQUIRES TO USE A LABEL STATE NOT FOR USE IN NEONATES RESULTS THE PROBLEMS WITH NEONATES AND TOXICITY OF BENZYL ALCOHOL
BENZYL ALCOHOL POISONING IS THE GASPING SYNDROME.

SOLVENTS AND VEHICLES FOR INJECTIONS

SODIUM CHLORIDE INJECTION, USP
STERILE ISOTONIC SOLUTION OF NaCl + water NO ANTIMICROBIAL AGENTS 154 mEq EACH SODIUM & CHLORIDE IONS / L USED AS A STERILE VEHICLE IN SOLUTIONS OR SUSPENSIONS OF DRUGS FOR PARENTERAL ADMINISTRATION USE TO RECONSTITUTE MEDICATIONS USED AS A CATHETER OR IV LINE FLUSH TO MAINTAIN PATENCY

SOLVENTS AND VEHICLES FOR INJECTIONS

BACTERIOSTATIC SODIUM CHLORIDE INJECTION, USP
STERILE ISOTONIC SOLN OF NaCl & WATER FOR INJECTION CONTAINS 1 OR MORE ANTIMICROBIAL AGENTS MUST BE SPECIFIED IN THE LABELING NOT BE PACKAGED IN 30ml WHEN USED AS A VEHICLE, CARE MUST BE EXERCISED ALSO USED TO FLUSH A CATHETER OR IV LINE TO MAINTAIN PATENCY USED IN SMALL QUANTITIES, BENZYL ALCOHOL IS SAFE BUT STILL NOT WITH

BACTERIOSTATIC SODIUM CHLORIDE INJECTION, USP

SOLVENTS AND VEHICLES FOR INJECTIONS

RINGERS SOLUTION, USP
STERILE SOLUTION OF
SODIUM CHLORIDE POTASSIUM CHLORIDE CALCIUM CHLORIDE

EMPLOYED AS A VEHICLE FOR DRUGS ACTS AS AN ELECTROLYTE REPLENISHER AND PLASMA VOLUME EXPANDER

SOLVENTS AND VEHICLES FOR INJECTIONS

LACTATED RINGERS SOLUTION, USP
RINGERS SOLUTION + SODIUM LACTATE ELECTROLYTE REPLENISHER SYSTEMIC ALKALIZER