Escolar Documentos
Profissional Documentos
Cultura Documentos
Injury or Infection
Pyrogens particularly IL-1 and IL-6 cross blood brain barrier to cause fever
Fever causes more vasodilation, inhibits bacterial growth, and stimulates more leukocytes
At the damage site, TLRs, GPCRs, Opsonin receptors and Cytokine receptors help immune cells recognize the pathogen
IL-8
TNF IL-1
Neutrophils
1. 2. 3. 4. 5. 6.
Extravastion Migration to damage site Recognition (PRR; TLR; NOD etc) Ox. Burst in Neutrophils M activation Repaired tissue
Vasodilation
IL-6
Fever