CHEMISTRY PROJECT

Drug: Antacid Effectiveness Analysis

To determine the neutralizing ability of antacids
in different brands using back titration

7C Candy Kwok (12)

Maggie Lam (13)
Cecilia Wu (23)
 THEORY

■ ANTI ACID IS A KIND OF MEDICINE

THAT USED TO CURE STOMACH
ACHE
■ IN THIS EXPERIMENT ,WE WILL PUT
THE ANTI ACID IN KNOWN
MOLARITY (O.1M)HCl AND IS BACK
TITRATED AGAINST STANDARD
NaOH SOLUTION.
■ WE CAN DETERMINE THE
NEUTRALIZING POWER OF EACH
BRAND OF SAMPLE BY RECORDING
THE VOLUME OF NaOH USED IN
BACK TITRATION
■ THE ONE WHICH USE LESS NaOH IN
BACK TITRATION MEANS THAT IS
THE STRONGER
 WEISEN-U

Composition

OUTER LAYER (yellowish green) INNER CORE (white to yellowish white)

Biodiastase 2000…25mg Methylmethionine Sulfonium Chloride…
25mg
Dried Aluminum Hydroxide Gel…192mg

Magnesium Hydroxide…159mg
 ACTAL
■ Composition
■ Al(OH)3 216 mg)
 Unknown

■ Composition
■ Aluminium/ magnesium hydroxide
simethicone
 Apparatus & reagents used
■ 0.1M NaOH solution
■ 0.1M HCl solution
■ 3 tablets of antacids of different brands
■ Phenophthalein indicator
■ Pipettes and pipette fillers
■ 100ml volumetric flasks
■ Electric balance
 Apparatus & reagents used
■ Mortars and pestles Distilled water in wash bottle
■ Hot plates Tap water.
■ White tiles
Burettes
Filter funnel
■ Thermometer
Labels
■ Stop watch Glass rods
■ Dropper Stands and clamps
■ Conical flask Beakers
Chemical reactions involved

■ Acid + Base  Salt + Water

■ NaHCO3 + HCl NaCl + H2O + CO2

■ CaCO3 + 2HCl CaCl2 + H2O + CO2

■ Al(OH) 3 + 3HCl AlCl3 + 3H2O
■ Mg(OH) 2 + 2HCl MgCl2 + 2H2O
■ No. of moles = Molarity × volume
Procedure
 Procedure
■ Transfer an antacid tablet to a clean mortar
and crush it in to a fine powder
■ Weigh the mortar filled with fine powder
■ Transfer the powder to a conical flask
■ Weigh the mortar again
■ Dissolve the antacid with 150ml of distilled
water by using hot plate
■ Cool the dissolved antacid to room
temperature (25℃ ) by immersing it in tap
water
■ Transfer the dissolved antacid to a 250ml
volumetric flask.
■ Fill the flask to the mark with water.
■ Cap the flask and invert several times to
mix well.
■ Use a pipette to transfer 25ml of dilute HCl
solution to the conical flask that HCl is in
excess.
■ Add the dissolved antacid to the conical
flask
■ Swirl the flask until the liquid become
slightly cloudy.
■ Clean, rinse and fill a burette with NaOH
solution
■ Release a small amount of NaOH solution
to leave the tip entirely filled.
■ Record the initial NaOH volume reading
from the burette.
■ Place a white tile under the flask.
■ Add 3-4 drops of phenothalein to the flask.
■ Add NaOH solution from the burette with
continuous swirling until the colour of the
liquid change from colourless to pale pink.
■ Record the final NaOH volume reading
from the burette.
■ Repeat the experiment by using antacids in
different brands.
 NO. OF MOLE OF HCl
NEUTRALIZED BY EACH SAMPLE
■ WEISEN U:(2.559/1000)mol
■ TAITAN:(2.12/1000)mol
■ HYDROSOIL:(1.24/1000)mol
 Source of error
■ Some ingredients in the anti-acid may affect
the pH value of the mixture and the result.
■ Loss of active ingredient during
transferring.
■ The meniscus didn’t sit at the graduated
mark of the burette or pipette.
■ The coatings of anti-acid may not dissolve
in acid or dissolve slowly.
■ The other ingredients may affect the
solubility of the bases inside the anti-acid
■ The reaction may not be complete.
■ Error in taking burette reading (0.05 cm3).
■ The end point may not equal to the
equivalence point.
■ The antacid was coloured and the solution
was cloudy and it was difficult to observe
the colour change and hence the end point
may be overshoot.
■ During the heating process, some of the
liquid may evaporate.
 Improvements

■ Sufficient time should be given for the

reaction of acid and base.
■ pH metre should be used to detect the end
point.