Alcohol Abuse/Malnutrtion Laennecs cirrhosis

Infection/Drugs Post necrotic cirrhosis

Biliary Obstruction Biliary cirrhosis

Destruction of Hepatocytes

Fibrosis/Scarring

S/S: Jaundice Bile Stasis

Obstruction of Blood Flow Increased Pressure in the Venous/Sinusoidal channels Fatty infiltration

Portal-vein hypretension

Increase in pressure resistance

S/S: Bleeding Varices Ascites Enlargement of the esophageal, umbilical, and superior rectus veins Incomplete clearing of protein metabolic waste

Increase in ammonia

Hepatic encephalopathy S/S: Neurologic Impairment Cerebral Edema

Coma

Death