Aplastic anemia(most common bone marrow toxicity)--- causes pancytopenia : a severe

decrease in all cell types: red blood cells, white blood cells, and platelets. Metformin--- causes LACTIC ACIDOSIS(SEVERE)

TCAs --- causes CARDIAC ARRYTHMIAS BLOOD DONATION:

APHERESIS--- involves removal of whole blood from a donor. Within an instrument that is essentially designed as a centrifuge, the components of whole blood are separated. One of the separated portions is then withdrawn, and the remaining components are retransfused into the donor. ALLOGENIC DONATION--- blood donated with unknown receiver AUTOLOGOUS DONATION--- blood donated for self use (SAFEST) DIRECTED DONATION--- with specific receiver Diphenhydramine HCl--- is an antihistamine. Its use prior to a blood transfusion decreases the likelihood of a transfusion reaction. Hepatitis B--- is the most common infection spread via blood transfusion. BLOOD TRANSFUSION--- large bore catheters are used since they are less likely to produce clotting problems Vesicants---highly active corrosive materials that can produce tissue damage even in low concentrations ASPIRIN--- not given to children <12 y.o to prevent Reyes Syndrome Topical agents--- produce a localized effect. When used with steroidal preparations, pt, becomes more prone to viral infections(e.g. varicella zoster, herpes-simplex) Diphenhydramine(Benadryl)/ hydroxyzine( atarax)--- are first generation OTC anti-histamines cause PARADOXICAL CNS STIMULATION MMR(mumps, MEASLES,Rubella)--- do not administer if pt. is allergic to egg(R: measles vaccine have egg proteins) IgG- major Ig, the only Ig that crosses the placenta igA-found in secretions esp in colostrum IgM- first Ig to be made by the fetus IgE-allergic reactions Oral contraceptives- cause thromboembolic complications(MI,DVT,),acne, headache, and dizziness)
Prostin VR Pediatric (alprostadil) Injection, USP 500 micrograms per mL---causes apnea to neonates weighing <2kg at birth