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PH/MAR 2012/PHC113

UNIVERSITI TEKNOLOGI MARA FINAL EXAMINATION

COURSE COURSE CODE EXAMINATION TIME

: : : :

INTRODUCTION TO PHARMACEUTICS PHC113 MARCH 2012 3 HOURS

INSTRUCTIONS TO CANDIDATES 1. This question paper consists of two (2) parts : PART A (10 Questions) PART B (7 Questions)

2.

Answer ALL questions from all two (2) parts in the Answer Booklet. Start each answer on a new page. Do not bring any material into the examination room unless permission is given by the invigilator. Please check to make sure that this examination pack consists of : i) ii) the Question Paper an Answer Booklet provided by the Faculty

3.

4.

DO NOT TURN THIS PAGE UNTIL YOU ARE TOLD TO DO SO This examination paper consists of 6 printed pages
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PART A (30 marks)

Answer ALL questions. Each question carries 3 marks 1. If 40 grams of 1.5% hydrocortisone is mixed with 60 grams of 2% hydrocortisone, what is the % w/w of hydrocortisone in final mixture? [Ans: 1.8%] 2. The recommended dose of drug A is 5 mg/kg/day. How many milligrams (mg) of drug A is required to be given every six hours to a 35 year-old patient? (Patient weight = 50kg) [Ans: 41.66mg every 6 hours.] 3. The pharmacist hands you a bottle of 75% alcohol solution and you are asked to mix it with 1000 mL of 10% alcohol solution in order to prepare 500 mL of 30% alcohol. How many milliliters (mL) of 75% alcohol should be used?[Ans: 153.84cc 75% solution is required] 4. A pharmacy assistant has 100 mL of 0.25% w/v stock solution. How many milliliters (mL) of a 1:2000 w/v solution can be made from the stock? [Ans: 500 mL] 5. A transdermal patch for smoking cessation contains 30 mg of liquid nicotine per patch. If nicotine has a specific gravity of 1.01, how many milliliters (mL) of the agent are required to manufacture 5 million patches? [Ans: 148500 mL] 6. Lactic acid Salicylic acid Trichloroacetic acid Flexible collodion q.s. ad 4g 10 g 2g 100 g

If the specific gravity of the above mixture is 0.781, what are the % w/v of lactic acid, salicylic acid and trichloroacetic acid in the mixture? [Ans: 3.12 % (w/v) lactic acid, 7.81 % (w/v) salicylic acid, 1.56 % (w/v) TCA] 7. Potassium Permanganate Tablets 0.2 g

Disp. # 50 Sig: 4 tablets in 5 pints of water and use as directed. Express the concentration, as a ratio strength, of the solution prepared according to the directions given in the prescription.[ Ans: 1:2956]

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8. The freezing point of a 5% w/v solution of boric acid is 1.55C. How many grams (g) of boric acid should be used in preparing 2000 mL of an isotonic solution? [Ans: = 33.54g Boric Acid]

9. Dextrose, anhydrous Sodium chloride Sterile water for injection 2.5% (E = 0.18) q.s q.s ad 1000 mL

Label : Isotonic dextrose and saline solution. How many grams (g) of sodium chloride should be used in preparing the above solution?[ Ans: 4.5g NaCl] 10. Calculate the osmolarity, in milliosmoles per milliliter (mOsm/mL), of a parenteral solution containing 2 mEq/mL of potassium acetate (KC2H3O2)? Assume complete dissociation of KC2H3O2 into K+ and C2H3O2 - ions. (Molecular weight of KC2H3O2 = 98) [Ans: 4 mOsm/mL]

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PART B

QUESTION 5 A clinical pharmacist fills a medication order calling for an infusion fluid of dextrose 5% w/v in a 0.9% w/v sodium chloride injection and 20 milliequivalents (mEq) of potassium chloride in a total volume of 500 mL. The intravenous infusion is administered through an intravenous (IV) set that delivers 10 drops per milliliter. The infusion has been running at a rate of 15 drops per minute for 10 hours. (Molecular weight : Dextrose = 180; NaCl = 58.5; KCl = 74.5) During the 10-hour period: a) How many milliequivalents (mEq) of KCl have been administered? [Ans: 36 mEq KCl] b) How many grams (g) of KCl have been administered? [Ans: 2682 mg or 2.682g KCl] c) How many milimoles (mmol) of KCl have been administered? [Ans: 36 mmol KCl]

(2 marks)

(1 mark)

(3 marks)

d) What is the total osmolarity (mOsm/L) of the infusion fluid? Express your answer to the nearest one decimal place. [Ans: 666 mOsmol/L of IV fluid] (4 marks)

QUESTION 7

a) Patients name: Amy Weight : 88 lb Age: 10 year-old Metronidazole suspension 7.5 mg/kg/day Ft. 5 mL/dose Sig. 5 mL b.d x 14 days Signed & Stamped Dr. LKK

i) How many milligrams (mg) of metronidazole will the patient received per dose? [Ans: 300 mg should taken in 2 divided doses, hence 1 dose will be 150 mg.] (3 marks) ii) How many milliliters (mL) of the suspension should be prepared and dispensed? [Ans: 140 mL] (2 marks)
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If metronidazole is available in 200 mg tablets, how many tablets should be crushed, in order to fill the prescription? [Ans: 21 tablets] (2 marks) b)

iii)

Acetaminophen drops Disp. 20 mL Sig. 0.8 mL q.d.s

If acetaminophen drops contain 1 g of acetaminophen per 20 mL container, how many milligrams (mg) are there in each prescribed dose? [Ans: 40 mg] (2 marks) If the dropper is calibrated to deliver 25 drops/mL, how many drops should be administered per dose? [Ans: 20 drops] (1 mark) ii)

i)

END OF QUESTION PAPER

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