Escolar Documentos
Profissional Documentos
Cultura Documentos
Edgar Odell Lovetts vision was to create an institution that was relevant and he could see that Houston, with its growth and potential, needed engineers to build the infrastructure the roads, petroleum industry and ship channel. That insight put Rice, from its inception, on track to being a strong engineering school, a path that we continue today. Our focus is to educate engineers who can be effectivewho can be leadersboth nationally and globally. And to continue to be a relevant, vibrant institution, we rely on our alumni to help make things happen here. After spending a year as dean of engineering at Rice, I am struck by how much of what I do day-to-day involves our alumni. Educating top-notch engineers who can go out into the world and have a positive impact on peoples lives takes a lot of hard work. It makes an enormous difference to have the experience, insight and connections of our alumni helping us to achieve this.
The George R. Brown School of Engineering has a large number of loyal, successful alumni who attribute some of that success to their Rice experience. They want to give back to Rice and to help our students and faculty achieve their goals. This is the way it should be. They step up to support design projects at the Oshman Engineering Design Kitchen. They support us by endowing faculty chairs that help us to retain and recruit star faculty. They give their time by getting involved with students in research, design projects and extracurricular activities. We deeply appreciate their contributions and we invite more of you to do the same. There are almost 11,000 living Rice Engineering alumni. I have met only a small fraction of you but I invite all of you to help us celebrate our first 100 years. Join us on campus October 12 at the Rice Engineering Alumni Association Honors Presentation at 4 p.m., then at the School of Engineering Reception which follows, both in Duncan Hall. In the meantime, let us hear from youwhat has your engineering education at Rice given to you? What can you do to help us keep our engineering program strong? Just go to engr.rice.edu, click on Alumni Centennial Blog and add your remembrances and reflections. I look forward to hearing from you.
Ned
Edwin L. Ned Thomas William and Stephanie Sick Dean of Engineering
Content
2 3 4 5 6 8 10 12 14 16 17 18 24 27 33 34 35 36 38 39 40
New faculty Entering the biology age Going viral to fight cancer Shedding light on polymer-based solar cells Making sense of big data The challenge of the nonlinear Cleaning up concrete Robots and molecular behavior Neuroengineering: A new world for engineers Engineering courses online? Of Coursera! Algorithms that go with the flow 100 years of engineering at Rice Student awards Faculty awards REA distinguished service medal REA names outstanding alumni Kate Hallaway: Changing of the REA guard Alumni spotlight: Al Hirshberg REA awards picnic Calendar of events Parting shot
New faculty
Two new faculty members, Jacob Robinson and Isabell Thomann, have joined the George R. Brown School of Engineering this year. Both are in the Department of Electrical and Computer Engineering. Assistant Professor Jacob Robinson received his B.S. in physics from the University of California at Los Angeles in 2003 and his M.S./Ph.D. in applied physics from Cornell University in 2008, where he wrote his thesis on nanoscale light confinement. At Cornell, working under Professor Michael Lipson, he developed silicon nanophotonic resonant cavities for sensing and enhancing the interaction between light and matter. His work led to the creation of new high-resolution, nearfield techniques to image the nanoscale optical modes confined in the cavities. Prior to coming to Rice, Robinson served as a postdoctoral researcher at Harvard in the laboratory of Hongkun Park, where he created vertical silicon nanowires that can interface with living cells. His work has been published in Optics Express, Physical Review Letters, Proceedings of the National Academy of Science, Cell and Nature Nanotechnology. Robinsons research interests include the potential applications for new biotechnology based on densely integrated nanoscale devices. His lab will focus on using emerging nanofabrication technology to develop large-scale, integrated bio-interfaces to provide experimental platforms for reverse-engineering neuronal circuits and will investigate the mechanistic cellular origins of neural diseases. Isabell Thomann joins the School of Engineering as an assistant professor. She earned a bachelors degree in 1998 from Technische Universitt Kaiserslautern in Germany and a diploma in 2001 from the Swiss Federal Institute of Technology (ETH). Thomann earned her Ph.D. in physics from the University of Colorado Boulder in 2009. While at UC Boulder, she was a member of JILA, the joint institute of UC and the National Institute of Standards and Technology (NIST). Upon graduation, she joined the research group of Professor Mark Brongersma at Stanford, where she was part of the pioneering research team attempting to prove that plasmonic resonances in metallic nanoparticles can be used to enhance the rate of solar fuel generation reactions. With a background in optics and solid-state physics, Thomanns research interests include expanding the potential applications of nanophotonics to the conversion of solar energy to chemical fuels. Her work at Rice will focus on designing and fabricating novel metal semiconductor hybrid materials to improve photocatalytic performance. Another focus will be to develop nanophotonic scanning probe techniques and time-resolved spectroscopy tools to advance the in situ characterization of nanostructured photoelectrochemical systems. While at Stanford, Thomann received a postdoctoral fellowship from the German Research Foundation. She is a member of the American Physical Society, the Optical Society of America, the Deutsche Physikalische Gesellschaft, the Materials Research Society, and the International Society for Optics and Photonics. She also serves as a reviewer for scientific journals such as Physical Review Letters, Optics Letters and Optics Express.
02 RICE ENGINEERING
Michael Deem
Marek Kimmel
Oleg Igoshin
Yousif Shamoo
The new interdisciplinary program in systems, synthetic and physical biology (SSPB) at Rice University has named its first director and is scheduled to begin enrolling doctoral students in the fall of 2013. The initiative is a joint venture between the George R. Brown School of Engineering and the Wiess School of Natural Sciences. Michael Deem, the John W. Cox Professor in Bioengineering and professor of physics and astronomy, has been named director. The timing is right. The faculty is enthusiastic and eager to launch an important graduate initiative, said Edwin L. Thomas, the William and Stephanie Sick Dean of Engineering. "This is a true partnership between the schools of natural science and engineering, and has the potential to put Rice at the front of this emerging field. Founders of the program include Yousif Shamoo, professor of biochemistry and cell biology; Marek Kimmel, professor of statistics and of bioengineering; and Oleg Igoshin, assistant professor of bioengineering. The SSPB program will combine curricula and research from both engineering and natural science, and will build further collaborative relationships with the Texas Medical Center.
Deem described SSPB as the intellectually exciting core of the life sciences in this century, and added: SSPB is at the heart of reading, understanding and using the elegant language of biology to construct and deconstruct genetic circuits that determine how cells operate, interact with each other and adapt to their environment. If we truly understand this language, we will be able to re-program cells to make new tissues, biofuels, materials and medicines. The emerging discipline aims at understanding biology from the quantitative and molecular perspectives, aided by recent developments in theory, computation, singlemolecule spectroscopy, biomaterials and biotechnology. Nature has a wealth of skills we have never fully harnessed for medicine and innovation," Shamoo said. Synthetic and systems biology will turn this century from the information to the biology age. New biomaterials and biomedicine will drive the engine of our economy and form the foundation of our future. Included in the SSPB program on the engineering side are faculty members in bioengineering, chemical and biomolecular engineering, computer science and statistics. From natural science are faculty in the biochemistry and cell biology, chemistry, ecology and evolutionary biology, and physics and astronomy departments.
RICE ENGINEERING 03
Junghae Suh
Supported by funding from the National Institutes of Health, Suh went to work at the Salk Institute for Biological Studies Laboratory of Genetics, where she did basic research in Professor Matthew Weitzmans laboratory, looking at how viruses manipulate human cells and how they might be engineered for biomedical use. Viruses are small supramolecular assemblies. They contain nucleic acid, DNA or RNA and are enclosed in a protein shell, or capsid. Their parasitic nature dictates they can only replicate by entering a cells nucleus and unloading their genetic cargo. At Salk, Suh began answering many of her questions about viruses, such as how they navigate through the dense cytoplasm and gain access to the cells nucleus, unpack their genetic information, and use the host cellular environment to replicate. When Suh joined Rices bioengineering program in 2007, she decided to combine her knowledge of viruses with engineering design principles to invent new virus-based nanotechnologies for cancer detection and treatment. At the time my mom was diagnosed, I was expecting my first child. Cancer became this real thing when I realized there is a possibility she wont get the chance to watch my son grow up. Today, the terrifying thought of hearing the words metastatic cancer is what drives me, said Suh. Through the support of a U.S. Department of Defense Breast Cancer Research Program Concept Award and a National Science Foundation CAREER Award, Suh is programming virus nanoparticles to travel through the circulatory system in a locked, inert configuration until they come across metastatic cancer sites. Unique biomarkers present in the tumor microenvironment activate the nanoparticles, enabling them to bind and kill cancer cells. To translate these novel technologies, Suh has initiated inter-institutional collaborative projects with Anil Sood, M.D. and Mien-Chie Hung, Ph.D., both at the University of Texas MD Anderson Cancer Center. The projects are aimed at delivering DNA-based therapeutics to either kill tumor cells or to make them more sensitive to the toxic effects of chemotherapeutics.
RICE ENGINEERING 05
making sense of
BIG
Among the clients seeking Hadley Wickhams help to manage and analyze large quantities of data are a shrimp farmer in Portugal, a cheese scientist in Denmark, an American airport architect and a planner at Disneyland hoping to figure out the most efficient way to manage long queues of customers. Statistics, in other words, isnt what it used to be or what you might think it is. Today, much of the discipline is organized around Big Data, massive, unwieldy quantities of information that stubbornly resist understanding. You might say that any data is big data if its too big, if it cant fit into the memory of a single computer. Most of what I deal with is not that big in a relative sense. You might call the focus of my research big small data, said Wickham, assistant professor of statistics at Rice University. Big data can be loosely defined as masses of information that defy management and analysis with conventional software. The notion is fluid, and some define big data as from 20 to 30 terabytes (or one billion bytes) to many petabytes (or one quadrillion bytes) of information in a single mass of data. After that comes the exabyte, or one quintillion bytes of information. My basic strategy is to break down large quantities of information into smaller quantities, so theyre easier to work with. I want to make it accessible to a larger audience, said Wickham, who earned his Ph.D. in statistics from Iowa State University in 2008 and joined the Rice faculty that year.
DATA
Hadley Wickham
DATA
Researchers estimate that 2.5 quintillion bytes of new data are created every day. That means roughly 90 percent of the data that exist have been created in the last two years, including everything from traffic behavior gathered by cameras, to social media communications, to cell phone signals. For instance, much of Allens medical work has focused on functional magnetic resonance imaging (fMRI), a process that tracks changes in the metabolism of the brain in response to various cognitive or behavioral tasks. The images are analyzed to determine whether apparent differences reveal changes attributable to the experimental activity or to extraneous patient movements or physiological processes. My interest is in developing mathematical tools to help scientists understand these massive amounts of data, sometimes billions of pieces of information, said Genevera I. Allen, assistant professor of statistics, and of electrical and computer engineering at Rice. Allen earned her B.A. in statistics from Rice in 2006, her Ph.D. in statistics from Stanford University in 2010 and joined the Rice faculty that same year. She is also on the faculty of the Baylor College of Medicine in its Department of PediatricsNeurology, and is a member of the Jan and Dan Duncan Neurological Research Institute at Texas Childrens Hospital. Each portion of the fMRI image, the voxel, represents a specific location in the brain, and each voxel is measured every few seconds. The voxels have both spatial and temporal dependencies. By mathematically modeling their space/time structure directly, Allen hopes the researchers can better understand the biological regions of interest in the brain. This work has obvious applications in an area thats getting more attention all the timeAlzheimers disease. Wed like to be able to model the healthy brain and a brain showing early symptoms of the disease, said Allen, who received an NSF grant in June to study multivariate analysis. For more than a decade, Wickham has been a user and developer of R, an open source programming language and software environment used in statistical computing and graphics. He first encountered R as an undergraduate in statistics at the University of Auckland, New Zealand, where R was created. His research focuses largely on data analysis and developing tools to help understand complex statistical models through visualization. Wickham has developed some of the most popular R packages, including ggplot2, plyr and reshape. When youre working with large quantities of data, its important to determine whats relevant and what isnt, whats important and what isnt. In my work, we try to build models and say this is real and this isnt, Allen said. Her goal is to develop mathematical and statistical tools, including convex optimization, multivariate analysis, and machine learning, and apply them to high-dimensional biological data. In this way, researchers can better distinguish biological reality (signal) from extraneous information (noise). Wickhams R packages are used for complex statistical analysis by the U.S. Air Force Research Laboratories, Mozilla Labs and the Vanderbilt University Center for Human Genetics Research. His ggplot2 was used by a doctoral student at New York University to visualize the Wikileaks data. My approach is to give people flexibility, Wickham said. I want to help them look at a small sub-set of data, so then can then scale it up.
06 RICE ENGINEERING
Genevera Allen
This work has obvious applications in an area thats getting more attention all the timeAlzheimers disease. Wed like to be able to model the healthy brain and a brain showing early symptoms of the disease. Genevera Allen
Chris Jermaine
RICE ENGINEERING 07
When a system displays nonlinear behavior, effects are often not proportional to their causes. Unexpected, sometimes undesirable things can happen. Chaos is a definite possibility. Just about everything is nonlinear. Its something we learn to live with, but in many engineering applications we must deal with it. In the area of dynamics and vibration, that can be a real challenge, said Andrew J. Dick, assistant professor of mechanical engineering and materials science at Rice University. One practical application of Dicks research into nonlinearity involves atomic force microscopes (AFM). Less than 30 years old, the device is a high-resolution form of microscopy useful in characterizing and manipulating matter at the micro- and nano-scales. Typically, an AFM consists of a cantilever probe with a pointed tip. The atomic interaction between the probe tip and the sample under study is intrinsically nonlinear. Dicks research suggests not a redesign of the AFM but new ways in which the use of the device might be improved, resulting in less impact between the probe and the sample, less risk of damage
Ive always been one to figure out puzzles. Thats part of the appeal of engineering and mathwhy does something happen the way it does? said Dick, who received his Ph.D. in mechanical engineering from the University of Maryland, College Park, in 2007, and joined the Rice faculty the same year. For the U.S. Air Force, Dick is studying collision events, trying to determine precisely what happens when one objectsay, an artillery shell or other projectilestrikes another. Customarily, the useful data is lost on impact. Dick models such events, measuring velocity and force to study wave propagation. This is basic research, building on math and physics. It also has applications in other areas, such as the blasting and drilling methods used in gas and oil production, said Dick, who spent two summers as a faculty fellow with the Air Force.
08 RICE ENGINEERING
HigH impact
senior design
What do you get when you combine a slingshot, a fish tank, a stack of 2-by-4s and five engineering students determined to help the United States Air Force? For Team CADET, whose adviser was Andrew Dick, the answer was a device to stop high-velocity projectiles without destroying them. With the Air Forces current testing methods, artillery shells are destroyed beyond recovery. The Air Force wants to know more about their behavior as they accelerate and decelerate. The challenge was to simulate high acceleration impacts in a non-destructive way and it turned out to have a hands-on, mechanical engineering focus, said Duncan Eddy, a senior in mechanical engineering and member of the Controllable Acceleration-Deceleration Equipment Tester design team. The other members graduated in May: Autumn Allen, Tremayne Kaseman, William Li and John Stretton. The Air Force simulates deceleration by firing cannons into walls. The strategy is expensive and the sensor module and target are destroyed in the process. CADETs goal was to sustain deceleration for at least 10 milliseconds without destruction. In the Oshman Engineering Design Kitchen, they machined a cylinder of aircraft-gauge aluminum, sealed a digital accelerometer inside and built a 14-foot wooden frame to hold a track of angle iron. On one end, they attached a slingshot made of surgical tubing; on the other, above the track, they fitted a 20-gallon fish tank of transparent plastic. Into Dick has also worked with Satish Nagarajaiah, Rice professor of civil and environmental engineering, and of mechanical engineering and materials science, studying the non-linear behavior of structures during earthquakes. Their goal is the attenuation of vibrations in buildings and bridges through the use of vibration absorbers. In addition to nonlinear vibrations and dynamics, Dicks research interests include impact dynamics, reduced order modeling and signal analysis. the bottom of the tank they drilled a line of 40 holes and sealed them with a removable rubber sheet. When the cylinder holding the accelerometer is fired with the slingshot, reaching a maximum velocity of 50 mph, the sheet is pulled and the water released. The falling water slows the cylinder, and the rate of deceleration is measured and recorded on the accelerometer. You can read more about this project and see a video demonstration at engineering.rice.edu/cadet/.
RICE ENGINEERING 09
Concrete is the most widely used synthetic material in the world. With more than 20 billion tons manufactured annually, it is also the third-largest manmade source of carbon dioxide, after the internal combustion engine and the generation of electricity. It is a dirty material, not good for the environment, but it is also very good at what it does. Who can imagine a human environment without concrete? No roads? No buildings? Its the only sustainable solution for the construction sector, said Rouzbeh Shahsavari, assistant professor of civil and environmental engineering at Rice University, who devotes his research to re-inventing cement, an essential ingredient in concrete. To begin with, definitions: Concrete and cement are not synonymous. Concrete is a composite material consisting of aggregate (gravel, crushed stone, sand), water and cement. Cement, often called Portland cement, is the binder for the aggregate, what Shahsavari calls the glue that holds it all together. The manufacture of cement results in five to 10 percent of all manmade carbon dioxide emissions worldwide. 1,000 kilograms of cement produced, and more rigorous emission standards proposed by the U.S. Environmental Protection Agency threaten to push the cement industry out of the U.S. and into developing countries. Its an energy-intensive material. Much work goes into its manufacture, Shahsavari said. Cement manufacturing releases carbon dioxide into the atmosphere in two ways. When calcium carbonate, a key ingredient in most cement processing, is heated, it produces lime and CO2. In addition, the gas is a significant byproduct of the energy burned in cement manufacturing. Shahsavaris strategy for solving the CO2 problem involves the problem to the sequencing of the human genome. Think of it as the concrete genome. As engineers, we want to recombine the genetic material, substitute other materials in different proportions and make something new at the molecular level, he said. Working with two doctoral students and a postdoc in his lab, Shahsavari begins with the assumption that tinkering with the ingredients without altering the essential reliability and low cost of cement is the goal.
10 RICE ENGINEERING
CONCRETE
cleaning up
We are, he said, unraveling the interplay between the chemistry, topological functionalization and mechanics of the basic building block of concrete, calcium-silicate-hydrate (C-S-H). Were encoding a set of functions on series of molecular C-S-H models. Shahsavari earned his Ph.D. in civil and environmental engineering from the Massachusetts Institute of Technology in 2010 and joined the Rice faculty the following year. While at MIT, he was part of a research team that determined that the calcium-silica-hydrate in cement is not a crystal. Rather, its a hybrid material sharing characteristics with both crystalline structures and the amorphous structure of frozen liquids. Shahsavari speculates that through molecular manipulation, cement might be developed that not only mitigates CO2 emissions during manufacturing but will possess superior physical properties as it hardens. This is what people are calling green cement, cement that is still strong and efficient but safer for the environment, he said.
concrete facts
Kilning limestone for cement dates back to 7000 B.C., and represents the first known industrial process. There is no such thing as a cement sidewalk or a cement mixer. The proper terms are concrete sidewalk and concrete mixer. By volume, cement comprises 10 to 15 percent of concrete. Robert Courland, author of Concrete Planet, estimates there are about 40 tons of concrete on the planet for every person alive, with another ton per person added yearly. About a ton of carbon dioxide is emitted for every ton of cement produced. Last year, the world produced 3.6 billion tons of cement.
In 2008, the U.S. consumed 93.6 million tons of cement, a 15.2 percent drop from the previous year. The decrease was attributed to the mortgage foreclosure crisis and resulting economic recession. In 2011, about 66 million tons of cement and 1.8 million tons of masonry cement were produced at 103 plants in 35 states. The sales value was about $6.6 billion. Most of it went to make concrete worth $37 billion. In descending order, Texas, California, Missouri, Florida, Pennsylvania, Michigan, and Alabama were the seven leading cement-producing states, accounting for 53 percent of U.S. production. Almost two-thirds of U.S. cement consumption occurs between May and October.
RICE ENGINEERING 11
When Lydia Kavraki, the Noah Harding Professor of Computer Science and Bioengineering, conducts one of her weekly meetings with the undergraduates, graduate students and post docs in her group, you can expect a stimulating academic discussion that leads to new ideas, but also the high spirits and overlapping conversations of a group of good friends. Because Kavrakis research has branched into two complementary disciplinesbioinformatics and roboticsthe students in her Biological and Physical Computing Lab reflect those interests and manage to learn from one another. Kavraki and Mark Moll, a research scientist and co-director of the lab, work to instill a hunger for excellence without compromising the relaxed, collegial atmosphere. As a graduate student, once you have your problem to work on, its tempting to disappear into a hole for months and work on it, said Matthew Maly, a third-year graduate student in computer science who studies robotics. One of the advantages of Professor Kavrakis meetings is the intellectual broadening you get. Im not in bioinformatics, but Ive learned a lot about it just by paying attention. Theres also something invigorating about those weekly meetings. Kavraki is passing along at least two intellectual legacies. In robotics, she has developed algorithms that permit collisionfree paths for complex and highly articulated robots. In bioinformatics, she has focused on the three-dimensional structure and flexibility of molecules, and the ways in which they interact with other biomolecules. She traces this pairing of interests to her childhood fascination with shape and motion. I am captivated by research that gives robots the ability to move in constrained physical environments. This research has been the initial inspiration for our efforts to understand the dynamic behavior and interactions of complex molecules, said Kavraki, a native of Greece who earned a bachelors degree from the University of Crete, and a Ph.D. from Stanford University in 1995, both in computer science. She joined the Rice faculty in 1996 and has a joint appointment to the program in structural and computational biology and molecular biophysics at the Baylor College of Medicine. Devin Grady, a fifth-year graduate student in computer science, applied to Rice in 2008 because he wanted to study robotics. Although he initially declined Rices admission offer, mostly because of the algorithmic focus of Kavrakis lab, he changed his mind after a phone call from her. Professor Kavraki called me and talked to me for an hour. I realized that what really interested me was the computer science aspect of robotics, the algorithms behind it. She made me feel like I was wanted here, said Grady, who earned his masters degree in computer science in 2011 and expects to get his Ph.D. in 2013. He works on devising motion policies for robots with limited sensing capabilities.
Among her many honors, Kavraki won the Duncan Award for excellence in research and teaching at Rice in 2004. She is also a Fellow of the Institute of Electrical and Electronics Engineers, the Association of Computing Machinery (ACM), the Association for the Advancement of Artificial Intelligence, the American Institute for Medical and Biological Engineering, and World Technology Network. She is co-author of Principles of Robot Motion, published in 2005 by MIT Press. Her contributions to robotics have been recognized with one of the most prestigious awards of the ACM, the Grace Murray Hopper Award. Ankur Dhanik earned his Ph.D. in mechanical engineering in 2010 from Stanford University, where his adviser was the robotics researcher Jean-Claude Latombe, who had also served as Kavrakis adviser. In 1996, Kavraki and Latombe published Probabilistic roadmaps for path planning in high-dimensional configuration spaces, a paper that revolutionized motion planning for robots. I first met Professor Kavraki at Stanford when she was visiting. She is one of the reasons I came to Rice, said Dhanik, who joined the Rice computer science department as a postdoctoral research associate in 2010. Dhanik has pursued the computational biology side of Kavrakis work. In collaboration with colleagues at the MD Anderson Cancer Center, he studies how cancer cells and the drugs that treat them interact at the molecular level. Professor Kavraki is an inspiration. She is very clearminded. She knows at every moment what she is doing, and her example makes you want to be as thoughtful and careful as she is, Dhanik said. Drew Bryant first met Kavraki in 2004 during a bioengineering summer internship. Throughout his undergraduate years he worked in her lab and earned a B.S. in bioengineering in 2007. After six months working for a biotech company in San Francisco, he returned to Rice, got his masters degree in computer science in 2010 and defended his Ph.D. thesis in May 2012. He now works as a software development engineer for Amazon.com in Seattle. My work involved investigating and predicting the interactions of proteins with other molecules in the cell. Our improved understanding will allow us to engineer better drugs, Bryant said. Kavraki taught him, Bryant said, not only the intellectual content of his discipline, but how to conduct himself as an engineer and how to write effectively. She teaches you to be a complete person, he said.
12 RICE ENGINEERING
I am captivated by research that gives robots the ability to move in constrained physical environments. This research has been the initial inspiration for our efforts to understand the dynamic behavior and interactions of complex molecules. Lydia Kavraki
RICE ENGINEERING 13
Listen to neuroengineers talk among themselves and you might mistake their more animated flights of conversation for science fiction. For instance, take Caleb Kemere, who recently joined the department of electrical and computer engineering (ECE) at Rice University as an assistant professor: I have seen a memory in a brain. I can look at thoughts as theyre happening. Ive looked into a hippocampus and said, There it is. Hes having a memory right now, and I can see it. Its an amazing thing, and Im seeing it in real time. Or Jacob Robinson, another recent arrival on the ECE faculty: Its amazing to see two cells talking to each other. Its like eavesdropping, and were listening in on their conversation. This is something we couldnt do until recently. Both men are sober researchers, practitioners in a newly minted and still loosely defined discipline that draws from neuroscience, biomedical engineering and physical medicine and rehabilitation, as well as electrical engineering and other fields. Robinson, who is an assistant professor, likens neuroengineering today to the promise posed by physics a century ago: Think of Einstein early in the 20th century, and think of how his work changed the world in just a few years. A flood of new techniques, often borrowed from disciplines like physics and engineering, are enabling us to study the brain at a level of detail that has never before been possible.
Caleb Kemere
neuroengineering:
Recently organized is the Center for NeuroEngineering (CNE), bringing together researchers from Rice, Baylor College of Medicine and the University of Texas Health Science Center. Its mission has been defined as the analysis and control of the nervous system in order to enhance and restore neuronal function. Robinson defines the emerging discipline as engineers moving in the direction of neuroscience. He notes that circuits are present in both electronics and the central nervous system, including the brain. He and his students in the Robinson Research Group study the behavior of neural circuits using nano-fabricated devices in tandem with optical, genetic and electrophysiological techniques. The conversations between cells involve thousands to millions of neurons. The challenge is to monitor the activity of all the cells involved in making decisions within the brain. Using new nanofabrication technology, he hopes to make such measurements possible. For instance, his lab uses vertical nanowires to deliver biomolecules into living cells, including neurons. Robinsons chief interest is in the interface between cells and manmade circuitry, what he calls plugging into the brain.
14 RICE ENGINEERING
Much of Kemeres research is devoted to the hippocampus, the region in the brain where spatial learning takes place and where memories are formed, stored and used. Injury or disease in the hippocampal circuit can lead to memory problems, such as those associated with Alzheimers and post-traumatic stress disorder, as well as depression and anxiety. Kemere aims at understanding the hippocampus at the systems level in healthy brains, how it goes wrong and what can be done to change how it functions. Were starting with basic brain science, learning how it works, he said. Can studying a traumatic memory in a rat help us understand the human brain? Were recording the activity of dozens of neurons in behaving rodents and manipulating genetically-selected populations of neurons using light, a technique known as optogenetics. By using information decoded from neural activity, Kemere can manipulate the hippocampal circuit. Detecting the neural activity that underlies individual memories in real-time, he hopes to selectively inhibit the recall or long-term storage of trauma. Truly, our field is in its infancy, but I can foresee a time when well be able to treat and maybe even eliminate such human diseases as drug addiction, epilepsy and Parkinsons disease. Who knows where it may lead? Kemere asked.
Jacob Robinson
Rob Raphael
RICE ENGINEERING 15
student awards
Marshall Scholarship
Kareem Ayoub, who graduated from Rice University in May with his degree in bioengineering, was among 41 students nationwide selected to receive a Marshall Scholarship which permits American students to pursue two years of graduate study at any educational institution in the United Kingdom. Calling the scholarship an immense honor, Ayoub plans to complete a masters degree in neuroscience at Oxford University and a masters in experimental neuroscience at Imperial College in London. From his freshman year at Rice, Ayoub conducted research in neuroimaging at Baylor College of Medicine. Focused on creating better presurgical planning for children with epilepsy, he co-authored several publications. During the summer of 2011, he collaborated with researchers at the Oxford Functional MRI Brain Centre through funding from Rices Wagoner Foreign Study Scholarship. Upon returning to the U.S., Ayoub plans to pursue an M.D./ Ph.D. in neurosurgery and to promote a collaborative scientific culture internationally. Ultimately, by practicing science in a global framework, scientists can work more intimately with our society and inspire the next generation of scientists, physicians and engineers, Ayoub said. This is an exciting time and I am excited to be a part of it.
Udall Scholarship
Christina Hughes, a senior civil engineering major, was one of 80 students selected to receive a Morris K. and Stewart L. Udall Scholarship, which recognizes the top sophomores and juniors nationwide who are committed to careers related to the environment. Active in Rices Engineers Without Borders chapter, Hughes has worked with the group since she was a freshman. She spent last summer in Brisbane, Australia, working for the global engineering firm Arup, one of the worlds leaders in sustainable infrastructure engineering. Hughes was born in Houston and her father worked for a large oil company, so she moved often and had lived on four continents before arriving at Rice in 2009. She said her interest in environmental issues began while she was in high school and living in Hong Kong. I dont really have a defining moment when I became passionate about the environment, but one course in particular that really shaped my outlook was [Director of Sustainability] Richard Johnsons Environmental Studies 302 about sustainability at Rice, Hughes said. I learned a lot about locally based environmental initiatives and it gave me the opportunity to develop one myselfa pilot project for a campus bike-share program. Ive been hooked on the idea of sustainability ever since. After graduating next spring, Hughes said she plans to pursue a masters degree in environmental engineering and possibly a global masters in development practice.
Ultimately, by practicing science in a global framework, scientists can work more intimately with our society and inspire the next generation of scientists, physicians and engineers. Kareem Ayoub
24 RICE ENGINEERING
Truman Scholarship
Rahul Rekhi is a senior majoring in bioengineering and economics, and one of 54 students selected for the prestigious Harry S. Truman Scholarship, which provides up to $30,000 for graduate study and is among the nations most coveted undergraduate awards. Hell use the scholarship to pursue a Ph.D. in bioengineering and a masters in public policy so he can work at the nexus of science, health and policy as a biomedical researcher and a national policymaker. Since his freshman year, Rekhi, who is also a 2011 Goldwater Scholar, conducted research on the computer modeling of angiogenesis under the direction of Assistant Professor of Bioengineering Amina Qutub. He has coauthored broadly on computational bioengineering, angiogenesis, synthetic biology, health policy, science policy and bioethics, and has presented papers at several national conferences. He serves as an editor of the Rice undergraduate science journal, Catalyst, and his bioengineering design team has a provisional patent pending on a cellphone-based bilirubinometer. Through these experiences, Ive realized that my broader social mandate as a bioengineer is not just to discover and design treatments in the lab, but also to help make those technologies broadly accessible, affordable and in sync with public policy, he said. This, I believe, is my civic duty, and the Truman gives me a chance to act on it.
Goldwater Scholarship
Stephanie Tzouanas, a junior, was one of 282 students to receive a 2012 Barry M. Goldwater Scholarship. She has conducted research at Rice and at the National University of Singapore. Majoring in bioengineering and minoring in anthropology and global health technologies, the Rice Century Scholar has studied bone-regeneration materials and techniques in the lab of Antonios Mikos since the summer after her junior year at Clear Lake High School. Century Scholars receive a two-year merit-scholarship and a research stipend for their work. She did research into angiogenesis as it pertains to bone regeneration in Professor M. Raghunaths Tissue Modulation Laboratory at the National University of Singapore under a Global Engineering Research Scholarship. She volunteers at Texas Children's Hospital. Tzouanas will chair the 2013 Rice Undergraduate Research Symposium. She is currently president of the Rice Biomedical Engineering Society and the Rice Society of Women Engineers, and is the Class of 2014 Representative to the Centennial Commission Advisory Board. Following graduation, she plans to pursue a doctorate in bioengineering to develop novel techniques to promote bone regeneration and treat hard-to-heal bone defects. The Goldwater Foundation, which awards the scholarship, aims to provide a continuing source of highly qualified scientists, mathematicians and engineers by awarding scholarships to college students who intend to pursue careers in these fields.
RICE ENGINEERING 25
P.E.O. Scholar
Rebecca Dahlin, a fourth-year graduate student in bioengineering, is among the 85 female doctoral candidates from the United States and Canada to receive a 2012-2013 Scholar Award from P.E.O. (Philanthropic Educational Organization) International. The Georgetown, Texas chapter of the organization nominated Dahlin for the merit-based scholarship that includes a one-time gift of $15,000. Dahlin is in the research group headed by Antonios Mikos, developing tissue engineering techniques to improve treatment of articular cartilage defects. She has designed a flow perfusion bioreactor to culture articular chondrocytes and bone marrowderived mesenchymal stem cells on porous polymer scaffolds. Rebecca is a truly exceptional graduate student and is making outstanding progress in her research to advance technologies for cartilage regeneration. I am thrilled for her and for this tremendous opportunity, said Mikos, the Louis Calder Professor of Bioengineering, professor of chemical and biomolecular engineering, and director of the Center for Excellence in Tissue Engineering at Rice. Dahlin is also a student of the Howard Hughes Medical Institute Med Into Grad program run by Rice and the University of Texas MD Anderson Cancer Center. The training program in Translational Cancer Diagnostics and Therapeutics Research for Bioengineers and Biophysicists integrates cancer biology, clinical medicine, translational research and bioengineering.
26 RICE ENGINEERING
Tony Mikos has made truly seminal contributions to biomaterials for tissue engineering. Dean Ned Thomas
RICE ENGINEERING 27
The computational theorist was given the engineering award for fundamental theoretical work that brought new tools and ideas to vaccine design, mathematical biology and nanoporous materials structure. The John W. Cox Professor of Bioengineering and professor of physics and astronomy uses tools from statistical physics to study problems related to evolution, immunology and materials. He received the award in January at the academys annual conference in Houston. Deem has developed methods for predicting vaccine effectiveness and for determining which strain of the flu to cover in annual vaccine formulations. His pepitope measure of antigenic distance explains how the influenza vaccine can have both positive and negative efficacy and has proven to be more predictive than the gold-standard animal model studies used by the World Health Organization. Deem has received a CAREER Award from the National Science Foundation and an Alfred P. Sloan Fellowship. He is a fellow of the American Institute for Medical and Biological Engineering, the Biomedical Engineering Society, the American Association for the Advancement of Science and the American Physical Society. Deem is a Phi Beta Kappa Visiting Scholar for the 2012-2013 year. The ODonnell Award includes a $25,000 honorarium, a citation and an inscribed statue. It was named after Dallas philanthropists Edith and Peter ODonnell, and was established in 2006.
28 RICE ENGINEERING
Guggenheim Fellowship
Luay Nakhleh, associate professor of computer science, has received a Guggenheim Fellowship to further his research creating new tools and methods for tracing genetic histories and the genetic links between species. Nakhleh and Rice alumni Dornith Doherty 80 and Nets Katz 90 were among the 181 Guggenheim Fellows announced in April. The scholars, artists and scientists represent 54 disciplines and were chosen from nearly 3,000 applicants. Funded by the John Simon Guggenheim Memorial Foundation, the fellowships are awarded on the basis of prior achievement and exceptional promise to allow recipients six months to a year in which they can work with creative freedom. Nakhleh, who is also an associate professor of ecology and evolutionary biology and of biochemistry and cell biology, was one of two recipients in the Guggenheim category of organismic biology and ecology. The award will help further his research into new methodologies and software to study the history of both specific genes and entire genomes. Historically, researchers have adapted a familiar familytree model for mapping out the lineage of genes. These gene trees show how genes have evolved from species to species through time. Nakhleh said gene trees are useful, but they do not capture the full complexity of evolution.
RICE ENGINEERING 29
Houchens earned a B.S. in 2000, a masters degree in 2001, and a Ph.D. in 2005, all in mechanical engineering, from the University of Illinois at Urbana-Champaign. He joined the Rice faculty in 2005. Houchens has also received the Claude L. Wilson Educator of the Year Award from the South Texas Section of the American Society of Mechanical Engineers (ASME). The honor recognizes his contributions to developing engineers for the benefit of society which will advance civilization. The award is due in part to Houchens role as chapter advisor to the Rice ASME student group.
IEEE Fellow
Lydia E. Kavraki, the Noah Harding Professor of Computer Science and professor of bioengineering, has been named a fellow of the Institute of Electrical and Electronics Engineers (IEEE). The IEEE has more than 385,000 members in 160 countries. Fellow designation is the highest grade of membership and is recognized by the technical community as an important career achievement. Kavraki has published more than 140 papers on such topics as robotics and computer science, computational biology, bioinformatics and metabolic network analysis, and co-authored Principles of Robot Motion, published in 2005 by MIT Press. Kavraki serves on the editorial board of the International Journal of Robotics Research, the Springer-Verlag Advanced Robotics Series, the ACM/ IEEE Transactions on Computational Biology and Bioinformatics and the Computer Science Review. She is a fellow of the Association of Computing Machinery, the Association for the Advancement of Artificial Intelligence, the American Institute for Medical and Biological Engineering and World Technology Network. She has received a National Science Foundation CAREER Award, the IEEE Robotics and Automation Society Early Academic Career Award, and a Sloan Fellowship. Kavraki won the Duncan Award for excellence in research and teaching at Rice in 2004. A native of Greece, Kavraki earned a bachelors degree in computer science from the University of Crete and a Ph.D. from Stanford University, also in computer science, in 1995.
v
Ma, professor of bioengineering at Rice and the Lodwick T. Bolin Professor of Biochemistry at Baylor College of Medicine, was honored for seminal contributions to the molecular bioengineering and biophysics fields, particularly in the development of multiscale computational methods for studying flexible supramolecular complexes.
AIMBE Fellows
Rice professors Jianpeng Ma and Kyriacos Zygourakis have been elected fellows of the American Institute for Medical and Biological Engineering (AIMBE). Fellows are nominated annually by their peers and represent the top two percent of the medical and biological engineering community. In addition to medical and biological engineers, AIMBE represents academic institutions, private industry and professional engineering societies. Ma and Zygourakis were inducted in February during a ceremony at AIMBEs 21st annual event in Washington, D.C.
32 RICE ENGINEERING
Ma develops algorithms for computer simulations of supramolecular complexes. His methods for structural refinement at lower resolutions, such as X-ray crystallography to decipher the three-dimensional arrangement of atoms, have deepened the field of molecular biophysics. Zygourakis, the chair and A.J. Hartsook Professor of Chemical and Biomolecular Engineering, and professor of bioengineering, was recognized for seminal contributions and visionary leadership in the application of engineering principles toward the elucidation of cell and tissue dynamics. With multiscale simulations and experimental studies, Zygourakis researches the interplay between cell population dynamics and extracellular mass transport that guides the formation of threedimensional tissues.
RICE ENGINEERING 33
Wayne Hale 76 and Troy Thacker 95 have been named 2012 Outstanding Engineering Alumnus (OEA) and Outstanding Young Engineering Alumnus (OYEA). Both say their Rice education gave them strong foundations that have helped their careers. Hale received his B.S. in mechanical engineering and earned a masters degree from Purdue University, where he did research in heat transfer. He spent more than 30 years at NASA, working in flight control and operations, before becoming director of human spaceflight at Colorado-based Special Aerospace Services. Ive been fortunate to do things that are so much fun, he said. Hale was a space-obsessed kid growing up in Hobbs, N.M. Knowing he wanted to work with NASA, he chose Rice for the schools proximity to the Johnson Space Center and its engineering program. While here, he served as president of the Student Government Association, and says he later drew on those leadership skills during one of his greatest career challenges. Following the space shuttle Columbia disaster in February 2003, Hale was asked to help change the culture at NASA, putting more focus on safety. Drawing on his experience at Rice, Hale worked with NASA team members to enhance the organization and reinvigorate the Shuttle program. By the time the Shuttle flew for the last time, wed changed the environment so that everything was done in a safer manner and every flight following the disaster went off without any safety incidents, he said, calling it his proudest accomplishment. Hale left NASA in 2010. At Special Aerospace Services, he consults and hosts seminars with aerospace and energy firms on safety, management, culture change and operations in high risk environments.
Thacker, with a B.S. in chemical engineering, is a selfdescribed serial business builder. He is president and CEO of R360 Environmental Solutions, which collects waste and disposes of it for oil and gas drilling firms. I took several environmental engineering classes at Rice, says Thacker, who grew up in Tulsa. And Ill never forget a field trip we took to a wastewater facility. It helped me see how we treat water and prepare it for reuse. His engineering background and environmental concerns inspired the founding of R360. Thacker believes many in the energy industry want to protect the environment but lack the know-how. I took a junior-level chemistry class on process engineering with Dr. Hightower, he said. And I learned as much about chemistry as I learned about how to think and how to solve problems. Thacker began his career in the power and energy industries with Morgan Stanley & Co. in Houston. A major player in energy-sector investments for 16 years, he was a founding partner of Paine & Partners, a private equity firm that manages some $3 billion in equity capital. He was responsible for many energy-sector investments, including Paradigm Geophysical and United American Energy Corporation. At the end of the day, engineering is about finding creative solutions to challenges. What I learned in my classes and collaborating with classmates and faculty at Rice gave me an edge.
34 RICE ENGINEERING
Youve said that its important to get young alumni involved with the REA. Why is this so?
We really want to bring more young alumni into the [REA] network. For one thing, being part of the REA allows them to keep a connection to both Rice and the School of Engineering. Were all passionate about our Rice experience, and this is a way to share our stories. Being involved with the REA is also a way for young alumni to network with each other and with more experienced professionals. We plan to host happy hours and other networking sessions. Im hoping this year well be able to expand those offerings to fit the busy schedules of all our alumni.
How does REA provide connections for current students and alumni?
Be an REA sponsor
Rice Engineering Alumni Sponsors receive special benefits throughout the year, including free admission to all REA events and invitations to special events with School of Engineering leaders. Multiple sponsorship levels are available, starting at $25 for Young Alumni. Sponsorship dollars support REA scholarship and grant programs, contributing to the success of the next generation of Rice engineers. Become a sponsor online. Click Make a Gift Now at giving.rice.edu. Select Rice Engineering Alumni (GF60) from the designation menu when submitting your gift.
Were working with Dr. Maria Oden to help highlight the OEDKs Around the Kitchen Table events. This is a chance for our alumni to see some of the projects student design teams are working on and for the students to talk to alumni who are working in the engineering industry now. We really want the benefits of belonging to REA to be two-fold: helping Rice students network with engineering professionals, and helping alumni see how their sponsorships and involvement are benefitting the next generation of engineers.
RICE ENGINEERING 35
Hirshberg credits Rice with giving him decision-making tools. At Sid Rich, he faced a troubling issue: hot and cold water. For years, it wasnt reliably available. Some rooms had cold water faucets that never got cold and sometimes were scalding. Hirshberg used his engineering know-how to figure out the problem and his position as college president to meet with then-university President Norman Hackerman and members of the facilities and engineering department. It turned out the college showers were built with single-knob valves containing a rubber bladder separating the hot and cold water. Some of the bladders had cracked and hot water mixed with the cold. Once we figured out the problem, we had it solved over the summer by replacing the shower valves with a better design, Hirshberg said. That project is a microcosm of what Ive done in my career: I look for all sources of information to get at a problem and then I work with a number of different stakeholders and personalities to get it fixed. Hirshberg and his wife, Suzanne Deetz Hirshberg 84, have three children, Kevin 09, Robin and Carolyn. Kevin, too, graduated with a degree in mechanical engineering and is also an automotive buff. Father and son race with the Porsche Club at the Texas World Speedway in College Station. A few months back, Hirshberg said, the car had a mechanical problem that was not discovered until race day. We just jacked it up and got to work, getting it back in shape to race before it was too late. For Hirshberg, thats a metaphor for lifehis, at least.
Outstanding Senior:
38 RICE ENGINEERING
Engineering Events
Unless noted otherwise, for details of these and other events, visit the Events link on the School of Engineering homepage: engr.rice.edu.
Rice Engineering Alumni
Alumni Honors Presentation
Dec. 4, 2012
alumni.rice.edu/rea
RICE ENGINEERING 39
parting shot
Workers return WillyWilliam Marsh Rice, the universitys founderto his rightful position after a group of engineering students pulled off the prank of the century in 1988 and rotated the one-ton statue 180 degrees. For the first time in 58 years, Willy faced not Lovett Hall but the Fondren Library. The cost of the prank? $400. The cost of undoing it? About $2,000. Engineering efficiency.
40 RICE ENGINEERING
credits
Rice Engineering Magazine is a production of the George R. Brown School of Engineering Office of Communications at Rice University. Dean Edwin L. Ned Thomas Associate deans Wade Adams Janice Bordeaux Keith Cooper Gary Marfin Bart Sinclair Editor Ann Lugg Writers Patrick Kurp Holly Beretto Designer Donald Soward Contributors Jade Boyd Shawn Hutchins Mike Williams Tania Chua Photography Jeff Fitlow Tommy Lavergne Donald Soward Anthony Vasser
Send comments or letters to the editor: Rice Engineering Magazine Rice University MS 364 P.O. Box 1892 Houston, Texas 77251 or email: engrnews@rice.edu