Escolar Documentos
Profissional Documentos
Cultura Documentos
Exclusive and variable for small volumes and applications in Biotechnology, Medicine, Pharmaceutics
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
Culture vessels
As single and double vessel with separable double vessels, vessel openings on same level with special lid, low overall height, and small diameters for space-saving assembly in multi systems. Working volumes can be varied in the ratio of 1:10 at volumes of 50 ml up to 100 or 250 ml for the inner vessels and 500 or 1000 ml for the outer vessel, respectively. Other volumes are 2.0 / 5.0 / 10.0 to 20.0 l Conversion of culture vessels for cell cultivation is possible as FixedBed, Fluidized Bed, and Stirred Fermenter, Miniature Reactor or separable double casing vessel. Each model may be used as a convert able basis.
Fittings
Sampling fittings, no pre-flow, comfortable handling. Option: automatic sampling with mini pumps. Exhaust air cooler high efficiency, low overall height. Option: Teflon-filter. Additional air fitting with stainless-steel coherer and Teflon filter. Stirring device with radial magnetic coupling, adjustable, different models of stirrers can be ordered. Passage Ports for sensors and fittings. Small , high lid-occupancydensity with up to 15 ports and good accessibility. Miniature-pO2 sensors adaptable 6 mm and 12 mm . Fast tube clutch for sterile connections.
Process controller FCU 05, allowing central operation of up to 8 culture vessels, remote control and easy Data exchange for: Speed, temperature, pH, redox, pO2, level or AF, continuous cultivation, gas mixture. Measuring and control module system, equipping depending on need.
Materials
High performance material Peek with high chemical and thermal resistance up to 260 Celsius and FDA admittance. Viton, Teflon, stainless steel, Duran glass, at problematical media is possible to replaces the steel through Titan.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
Bioreactors, standard volume 0.5, 1, 2.5, 5, 10 and 20 Litres Vessels with lids from PEEKmaterial to minimize of weight and costs. The temperatures can be corrected fast by dip sensors of stainless steel or titanium. The fermenters can be equipped modularly with sensors and fittings. They can be modified or upgraded for any application by sterile magnetic couplings and various stirring systems. Design examples Stirred Fermenter with axially stirring system for homogeneous and gentle mixing of cell cultures (1). Fixed Bed system with radial mixing for batch and continuous cell cultivation (2).
The stirring bioreactors (1, 3, 4, and 5) are used for cell cultivation of the shear stress insensitive cells like bacteria and many plant cells. They work completely automatically and are equipped with stirrer, magnet clutch, probes and fittings. They can be converted with few basic components easily into fixed bed system (2 and 6), fluidized bed or airlift Fermenter (7). The converted bioreactors as a Fixed-bed system can be used in the medical research and pharmaceutical industry for the cultivation of adherent, humane and animal cells, or as airlift or fluidized bed Fermenter in the cultivation of shear stress sensitive cells. The mini-bioreactors (4) are standard models and be offered with double vessel coats for the cultivation of the insensitive cells. The mini-bioreactors stand out due to separable double coat with a short gap, high lid occupancy density and space-saving forms in multi systems. The special feature of these bioreactors is the saving of expensive nursing media with the same cell yield results by low height and small diameter of the inner vessel. The mini bioreactors can be sent as 0.5 or 1 Litres of standard instruments.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
Stirring bioreactors
Technical data
Work volume Sterilization Temperature range PH range Stirring speed (only stirred bioreactors) Temperation 0,5L Autoclaving o 5 60 C 3 - 10 0 2000 1L Autoclaving o 5 60 C 3 - 10 0 2000 2,5L Autoclaving o 5 60 C 3 - 10 0 2000 5L Autoclaving o 5 60 C 3 - 10 0 1000 10L / 20L Autoclaving o 5 60 C 3 - 10 0 1000
Operation
PH regulation Gas supplement Stirring (only stirred bioreactors) Ring-economizing javelin (air lift/fluidized reactor) Waste gas condenser Test recipient system Magnetic clutch (only stirred reactors) Diving pipes Electrodes and cable Lights PC interface Data acquisition process control system
Heating stick or Double vessels Batch, Fed-Batch, Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 Marine propeller or Paddle stirrer yes
Heating stick or Double vessels Batch, Fed-Batch Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 marine propeller or paddle stirrer yes
Heating stick or Double vessels Batch, Fed-Batch Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 marine propeller or paddle stirrer yes
Heating stick or Double vessels Batch, Fed-Batch Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 marine propeller or paddle stirrer yes
Heating stick or Double vessels Batch, Fed-Batch Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 marine propeller or paddle stirrer yes
On enquiry we can inform the users about the sizes and the weights of the bioreactors.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32 Owner: Dr. S. Mohazzeb Email: info@medorex.com http://www.medorex.com HRA: 130920 AG Gttingen UID: DE 239250100 IBAN: DE70 2625 0001 0000 0118 25 BIC: NOLADE21NOM Kreis-Sparkasse Northeim Kto-Nr. 11825 BLZ 262 500 01
Operation
Batch, FedBatch Chemo stat, continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 yes yes yes yes yes on enquiry on request on request on request
Batch, Fed-Batch Batch, Fed-Batch Chemo stat, Chemo stat, continuous continuous Acid, alkali or CO2 gazing Air, O2, N2, CO2 yes yes yes yes yes on enquiry yes yes yes Acid, alkali or CO2 gazing Air, O2, N2, CO2 yes yes yes yes yes on enquiry T yes yes
PH regulation Gas-addition (outer vessel) Gas humidification Waste gas condenser Test recipient system Diving pipes Electrodes and cable Lights PC interface Data acquisition Process control system
The sizes and the weights of the bioreactors can be sent if required.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
Multiferm A new multiple cell culture bioreactor for medical and scientific pretesting and tests
"Multiferm" is an automated and easy-to-use 12-fold fixed-bed fermenter system and best suitable for the parallel-cultivation of sensitive animal, human and other shear-sensitive cells which are without stable cellwall. The system is used in the production of monoclonal antibodies, cultivation of adherent and recombinant cells and the use in the cell-physiological studies of tissue cells such as tumour cells, primary cells, stem cells, liver and kidney cells. The fixed-bed system is equipped with the needed measurement and control engineering, probes and sensors, peristaltic pumps, gas supply, control program and computer for the saving, evaluation and transfer of the data to other computers. The fixed-bed reactors are made of Duran glass and are fitted space-saving in the middle of a compact 1.5 l media conditioning vessel. The conditioning vessel is made of Duran glass also. This makes possible to watch, to steer and to check the development of the cell cultivation better. The lid, the in- and exits are made of insensitive Peek material to protect the sensitive cells from damages by free metal molecules from the usual metal lids. The fixed-bed material consists of highly porous glass sinter pearls or another suitable carrier material and is in the fixedbed reactors. The cells are transferred to the surface of the carrier material in the fixed-bed reactors. They grow and increase on, around and between the carrier materials and can be used for further tests and examinations. Depending on the cell-types and growth-needs "Multiferm" is best suitable for the parallel cultivation of the same or different cell lines which grow under the same or almost the same growth-conditions. The Fermenter system is excellently suitable for the pretesting and testing of medicine, biotechnology, pharmaceutical and food industry.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
The weight and the size of the bioreactor can be sent if required.
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32
medorex e.K. Industriestr. 2 Tor 1 37176 Noerten-Hardenberg, Germany Phone: +49 (0)5503-8086-62 Fax: -32