Medication Summary

Acetylcholine esterase (AChE) inhibitors are considered to be the basic treatment of myasthenia gravis (MG). Edrophonium is primarily used as a diagnostic tool owing to its short half-life. Pyridostigmine is used for long-term maintenance. High doses of corticosteroids commonly are used to suppress autoimmunity. Patients with MG also may be taking other immunosuppressive drugs (eg, azathioprine or cyclosporine). Adverse effects of these medications must be considered in assessment of the clinical picture. Bronchodilators may be useful in overcoming the bronchospasm associated with a cholinergic crisis.

Anticholinesterase Inhibitors
Class Summary
Anticholinesterase inhibitors interfere with the degradation of acetylcholine (ACh) by AChE, thereby increasing the amount of ACh available at the neuromuscular junction (NMJ) and increasing the chance of activating the acetylcholine receptors (AChRs). Any medication that increases the activity of the AChRs can have an effect on MG. AChE inhibitors continue to be used as first-line treatment of MG. The improvement is usually partial and frequently decreases after many weeks to months of treatment. Besides, these agents are not as beneficial for ocular MG as for generalized MG. Hence, they often are complemented (and sometimes replaced) with immunosuppressive therapy. View full drug information

Adult Dosing & Uses

Dosing Forms & Strengths
inj solution

5mg/mL

tablet, controlled release

180mg

tablet

60mg

syrup

60mg/5mL (240mL)

Myasthenia Gravis
Tablets/syrup: 600 mg/day spaced to provide maximum relief Sustained release: 180-540 mg PO qD-BID; not to exceed 1.5 g/day

Other Indications & Uses

Antidote for nondepolarizing neuromuscular blkrs

Pediatric Dosing & Uses

Dosing Forms & Strengths
inj solution

5mg/mL

tablet, controlled release

180mg

tablet

60mg

syrup

60mg/5mL (240mL)

Children
7 mg/kg/d PO divided q4hr 0.05-0.15 mg/kg IV/IM q4-6hr; not to exceed 10 mg/dose

Neonates
5 mg PO q4-6hr 0.05-0.15 mg/kg IV/IM q4-6hr; not to exceed 10 mg/dose

Pyridostigmine bromide (Mestinon, Regonol)

Pyridostigmine acts in smooth muscle, the central nervous system (CNS), and secretory glands, where it blocks the action of ACh at parasympathetic sites. An intermediate-acting agent, it is preferred in clinical use to the shorter-acting neostigmine bromide and the longeracting ambenonium chloride. It starts working in 30-60 minutes; effects last 3-6 hours. Individualize the dose; MG does not affect all skeletal muscles similarly, and all symptoms may not be controllable without adverse effects. In critically ill or postoperative patients, administer the drug intravenously (IV). In the United States, pyridostigmine is available in 3 forms: 60-mg scored tab, 180-mg timespan tablet, and 60-mg/5 mL syrup. The effects of the timespan tablet last 2.5 times longer. The timespan form is a useful adjunct to regular pyridostigmine for nighttime control of myasthenic symptoms. The absorption and bioavailability of the timespan tablet vary among subjects. It should be used only at bedtime, and patients need close monitoring for cholinergic adverse effects. View full drug information

Neostigmine (Prostigmin)

Adult Dosing & Uses

Dosing Forms & Strengths
injectable solution

0.5mg/mL 1mg/mL

tablet

15mg

Myasthenia Gravis
Acute: 0.5-2.5 mg IV/IM/SC qDay Maintenance: 15-375 mg/day divided TID/QID PO Use injectable with 0.6-1.2 mg atropine IV to counteract muscarinic effects

Myasthenia Gravis Diagnosis

0.022 mg/kg IM x1 Discontinue all anticholinesterase agents >8 hours Give atropine 0.011 mg/kg IV (if IM give 30 minutes before) with neostigmine 0.022 mg/kg IM

If cholinergic response, stop test & give 0.4-0.6 mg atropine IV If inconclusive, retest another day with neostigmine 0.031 mg/kg IM preceded by 0.016 mg/kg atropin

Neostigmine inhibits the destruction of ACh by AChE, thereby facilitating the transmission of impulses across the NMJ. It is a short-acting AChE inhibitor that is available in an oral form (15 mg tablet) and a form suitable for IV, intramuscular (IM), or subcutaneous (SC) administration. Its half-life is 45-60 minutes. It is poorly absorbed from the gastrointestinal (GI) tract and should be used only if pyridostigmine is unavailable. Individualize the dose for all patients.

Edrophonium (Enlon)

Edrophonium is primarily used as diagnostic tool to predict the response to longer-acting cholinesterase inhibitors. Like other cholinesterase inhibitors, it decreases the metabolism of ACh, increasing the cholinergic effect at the NMJ.

Corticosteroids
Class Summary
Corticosteroids are anti-inflammatory and immunomodulating agents used to treat idiopathic and acquired autoimmune disorders. They were among the first immunomodulating agents used to treat MG and still are used frequently and effectively. They are typically used in moderate or severe cases that do not respond adequately to AChE inhibitors and thymectomy. Long-term treatment with corticosteroids is effective and may induce remission or cause marked to moderate improvement in most patients. Transient worsening might occur initially; clinical improvement then shows after 2-4 weeks. These agents are usually given over 1 or 2 years before tapering is begun. Remissions are noted in 30% and marked improvement in 40%. Corticosteroids act in both ocular MG and generalized MG. They can be combined with other immunosuppressive medications for better effect with lesser dose and shorter duration of administration. Pulsed IV steroids might be beneficial in refractory patients. View full drug information

Prednisone

Prednisone is most commonly used corticosteroid in the United States. Some experts believe that the long-term administration of prednisone is beneficial, but others use the drug only during acute exacerbations to limit the adverse effects of chronic steroid use. Prednisone is effective in decreasing the severity of MG exacerbations by suppressing the formation of autoantibodies. However, clinical effects often are not seen for several weeks. Significant improvement, which may be associated with a decreased antibody titer, usually occurs in 1-4 months. An alternate-day regimen may minimize adverse effects. A trial of steroid withdrawal may be attempted, but most patients on long-term corticosteroid therapy relapse and require re-institution of steroids. View full drug information

Adult Dosing & Uses

Dosing Forms & Strengths
oral solution

5mg/5mL

tablet

1mg 2.5mg 5mg 10mg 20mg 50mg

Usual Dose Range

5-60 mg/day PO qDay or divided BID-QID

Methylprednisolone (Solu-Medrol, Medrol, A-Methapred)

Methylprednisolone may be used in place of prednisone in patients who are intubated and in those unable to tolerate oral intake. It decreases inflammation by suppressing the migration of polymorphonuclear (PMN) leukocytes and reversing increased capillary permeability.

Immunomodulators
Class Summary

MG is an autoimmune disease, and immunomodulatory therapies have been used for these disorders since introduction of steroids. Although no rigorous clinical trials have established the efficacy of immunomodulatory therapies in MG, several uncontrolled trials and retrospective studies support use of such therapies. The therapies used in MG include prednisone, azathioprine, IV immunoglobulin (IVIg), plasmapheresis, and cyclosporine. View full drug information

Azathioprine (Imuran, Azasan)

Adult Dosing & Uses

Dosing Forms & Strengths
tablet

50mg

powder for injection

100mg/vial

oral suspension

50mg/mL

Azathioprine is an imidazolyl derivative of 6-mercaptopurine (6-MP). Many of its biological effects are similar to those of its parent compound. Both compounds are eliminated rapidly from the blood and are oxidized or methylated in erythrocytes and liver. No azathioprine or 6-MP is detectable in urine 8 hours after being taken. Azathioprine antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. The mechanism whereby it affects autoimmune diseases is unknown. It works primarily on T cells, suppresses hypersensitivities of the cell-mediated type and causing variable alterations in antibody production. Immunosuppressive, delayed hypersensitivity, and cellular cytotoxicity tests are suppressed to a greater degree than antibody responses. Azathioprine is the second most commonly used immunosuppressive medication in MG. It is reserved for patients with either steroid failure or unacceptable effects from prolonged steroid use. Furthermore, it can be used for steroid-sparing effects to lower steroid doses. One drawback is that it works very slowly; it may require 6-12 months to exert its therapeutic effect. Up to 10% of patients may have idiosyncratic reaction disallowing use. Do not allow the white blood cell (WBC) count to drop below 3000/L or the lymphocyte count to drop below 1000/L. Azathioprine is available in tablet form for oral administration or in 100-mg vials for IV injection.

View full drug information

Cyclosporine A (Neoral, Sandimmune, Gengraf)

Cyclosporine A is an 11-amino acid cyclic peptide that is a natural product of fungi. It acts on T-cell replication and activity. It is a specific modulator of T-cell function and an agent that depresses cell-mediated immune responses by inhibiting helper T-cell function. Preferential and reversible inhibition of T lymphocytes in the G0 or G1 phase of the cell cycle is suggested. Cyclosporine binds to cyclophilin, an intracellular protein, which, in turn, prevents formation of interleukin (IL)2 and subsequent recruitment of activated T cells. It has about 30% bioavailability, but there is marked individual variability. It specifically inhibits Tlymphocyte function with minimal activity against B cells. Maximum suppression of Tlymphocyte proliferation requires that drug be present during first 24 h of antigenic exposure. Cyclosporine A suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions (eg, delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft-vs-host disease) for a variety of organs. Cyclosporine A is used as a second-line immunosuppressive agent and has been shown effective in patients with MG in prospective, double-blind, placebo-controlled clinical trial. This agent does have some significant adverse effects (more serious than those of azathioprine), which usually preclude its use as first-line immunosuppressive therapy. However, in patients who are at high risk for adverse steroid effects, it can be used as initial therapy. The onset of action is within a few weeks to months, similar to that of prednisone. View full drug information

Cyclophosphamide

Cyclophosphamide is an alkylating agent that interferes with cell proliferation. It is more effective against B cells than against T cells, which makes it a good choice in an antibodymediated disease such as MG. Because of potential for serious side effects, it is usually reserved for more severe cases where more routinely used immunotherapy has failed because of lack of efficacy or intolerable adverse effects. View full drug information

Mycophenolate mofetil (CellCept, Myfortic)

Mycophenolate mofetil, a derivative of mycophenolic acid (MPA), blocks the de novo pathway of guanosine nucleotide synthesis by inhibiting the activity of inosine

monophosphate dehydrogenase and thus inhibiting de novo purine synthesis. Both T and B lymphocytes are highly dependent upon the de novo pathway, whereas other cells use the purine salvage pathway of nucleotide synthesis. As a result, MPA selectively inhibits lymphocyte activity. Mycophenolate mofetil has been shown to be effective in MG and is recommended as a steroid-sparing immune modulator. The onset of action is variable and usually starts between 1 and 12 months. View full drug information

Rituximab (Rituxan)

Rituximab is a genetically engineered chimeric murine-human monoclonal antibody (mAb) directed against the CD20 antigen found on the surfaces of normal and malignant B cells. The antibody is an IgG1 immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences.

Immune Globulins
Class Summary
Immunoglobulins are commonly used in admitted patients and rarely administered in the emergency department (ED). IVIg is recommended for MG crisis, in patients with severe weakness poorly controlled with other agents, or in lieu of plasma exchange at a dose of 1 g/kg. IVIg is effective in moderate or severe MG worsening into crisis but does not exhibit value in mild disease. Data do not support or exclude a role for IVIg in chronic MG. The use of IVIg in a seronegative patient is not supported by the literature. View full drug information

Immune globulin intravenous (Gamimune, Gammagard, Octagam)

High-dose IVIg successfully treats MG, though the mechanism of action is unknown. It is used in crisis management (eg, myasthenic crisis and the perioperative period) instead or in combination with plasmapheresis. Like plasmapheresis, it has a rapid onset of action, but the effects last only a short time.

Beta2 Agonists
Class Summary

Beta-agonists are used to alleviate the respiratory distress and bronchospasm resulting from the cholinergic medications used to treat MG. View full drug information

Albuterol, salbutamol (Proventil, Ventolin, ProAir)

Standard unit doses of beta-agonist nebulizer treatment may improve respirations in a cholinergic crisis. Continuous beta-agonist nebulizer treatment may be indicated in severe cases. Otherwise, the standard dosing regimen of 2 puffs from a metered dose inhaler or 2.5-5 mg nebulized every 4-6 hours often will suffice in achieving bronchodilation.

Anticholinergics, Respiratory
Class Summary
Anticholinergic bronchodilators cause the reversal of cholinergic medication effects that induce bronchospasm. These drugs can act synergistically or independently with betaagonists to produce bronchodilation. They are quaternary amines, and they are poorly absorbed across the pulmonary epithelium. As a result, they have minimal systemic side effects. View full drug information

Ipratropium (Atrovent)

Ipratropium is chemically related to atropine. It has antisecretory properties and, when applied locally, inhibits secretions from the serous and seromucous glands lining the nasal mucosa. View full drug information

Glycopyrrolate (Robinul, Cuvposa)

Glycopyrrolate acts in smooth muscle, the central nervous system (CNS), and secretory glands, where it blocks the action of ACh at parasympathetic sites.

immune globulin IV (IGIV) (Rx) - Gammagard S/D, Carimune NF, more..Carimune, Flebogamma, Gammagard, Gamunex, Gamunex-C, IV Immune Globulin, Iveegam EN, IVIG, Octagam, Privigen

Class: Immune Globulins

High-dose IVIg successfully treats MG, though the mechanism of action is unknown. It is used in crisis management (eg, myasthenic crisis and the perioperative period) instead or in combination with plasmapheresis. Like plasmapheresis, it has a rapid onset of action, but the effects last only a short time.

Adult Dosing & Uses

Primary Immunodeficiency Syndrome
Carimune NF

200 mg/kg IV q4wk or may increase frequency based on patient response

Gammagard S/D, Gamunex, Gamunex-C, Gammagard Liquid

300-600 mg/kg IV q4wk; adjust based on dosage and interval as well as serum IgG concentrations

Gammagard Liquid (SC administration)

Initial SC dose: Previous IV dose/wk X 1.53/IV dosing interval (in weeks) Initial SC infusion rate: Do not exceed 30 mL per infusion site and do not exceed rate of 20 mL/hr/site Maintenance SC dose: Based on clinical response and target IgG trough level Maintenance SC infusion rate: Do not exceed 30 mL per infusion site and do not exceed rate of 20-30 mL/hr/site

Gammaplex

300-800 mg/kg IV q3-4wk

Octagam

300-600 mg/kg IV q3-4wk Initial infusion rate: 0.5 mg/kg/min IV

Privigen

200-800 mg/kg IV q3-4 wk; adjust based on dosage and interval as well as serum IgG concentrations

Immune Thrombocytopenic Purpura

Gammagard S/D

1000 mg/kg IV; adjust doses based on platelet count and patient response; may administer up to 3 separate doses qOD PRN

Privigen

1000 mg/kg/day IV for 2 days

Gamunex

1000 mg/kg/day IV for 1-2 days or 400 mg/kg/day for 5 days

Gamunex-C

1 g/kg IV x 2 days or 400 mg/kg IV x 5 days Initial infusion rate is 1 mg/kg/min; may increase to 8 mg/kg/min if tolerated

Carimune

Acute: 400 mg/kg/day IV for 2-5 days Chronic: 400 mg/kg IV PRN to control significant bleeding or maintain platelet coung >30,000/cu.meter

Kawasaki Disease
Initiate IVIG within 10 days of diagnosis; use in combination with aspirin 80-100 mg/kg/day divided QID for 14 days; administer aspirin at 3-5 mg/kg IV qD for >6-8wk Gammagard S/D

1000 mg/kg IV once administered over 10 hr OR 400 mg/kg/day IV for 4 days; administer within 7 days of onset of fever

Bone Marrow Transplant

500 mg/kg IV beginning on days 7 & 2 pre-transplantation, THEN qWk through 90 d posttransplantation

Chronic Inflammatory Demyelinating Polyneuropathy

Gamunex

Load: 2 g/kg IV divided BID/QID for 2-4 days Maintenance: 1000 mg/kg/day IV for 1 day q3wk or 500 mg/kg/day for 2 days q3wk

Gamunex-C

Load: 2 g/kg IV Maintenance: 1 g/kg IV as a single dose or 500 mg/kg IV x 2 days q3weeks Initial infusion rate is 2 mg/kg/min; may increase to 8 mg/kg/min if tolerated

B-cell Chronic Lymphocytic Leukemia

Gammagard S/D

400 mg/kg/dose IV q3-4wk

Dermatomyositis (Off-label)
1 g/kg IV x2 consecutive days, THEN 400 mg/kg qMth, generally for 6-mth course

Guillain-Barre; Lambert-Eaton Myasthenic; Stiffman Syndrome (Off-label)

400 mg/kg IV qD x5 d or 1 g/kg qD x 2 d

Neonatal Hemochromatosis (Off-label)

1 g/kg IV qWk to pregnant woman 18th week until end of gestation

Multifocal Motor Neuropathy (Orphan)

Orphan indication sponsor

Baxter Healthcare Corporation, Baxter Bioscience; Westlake Village, CA 91362

Stiff Person Syndrome (Orphan)

Orphan indication sponsor

Octapharma USA, Inc; 121 River Street; Hoboken, NJ 07030

Other Information
Monitor: vascular status continuously, have epinephrine ready; see individual products for specific information on doses & infusion details

Other Indications & Uses

Primary immunodeficiencies Bone marrow transplant indicated for Gamunex (Canada); was indicated for one US product (Gamimune N) which has been discontinued; other brands used off-label Off-label : secondary immunodeficiencies, dermatomyositis, Guillain-Barre synd, myasthenia gravis, multifocal motor neuropathy, relapsing-remitting multiple sclerosis, Lambert-Eaton myasthenic syndrome, stiffman syndrome, pemphigus vulgaris, SLE, HDN, multiple

myeloma, TSS, streptococcal necrotizing fasciitis, Churg-Strauss syndrome, refractory autoimmune hemolytic anemia, opsoclonus-myoclonus, Hyper IgE syndrome, FAIT, Parvovirus B19 infection w/ anemia, delayed pressure urticaria, epidermolysis bullosa, neonatal hemochromatosis, birdshot retinochoroidopathy, acute disseminated encephalomyelitis, Rasmussen's syndrome, enteroviral meningoencephalitis