Acute Leukemia Acute Myeloid Leukemia (AML) Acute Lymphoid Leukemia (ALL) M0 M1 M2 M3

malignant WBC disorder characterized by a mutation in the bone marrow decreasing WBCs, RBCs, and platelets. Two categories are myeloid and lymphoid. Type of acute leukemia that targets PMNs, monocytes, RBCs, and platelets. Type of acute leukemia that targets B and T cells. AML without maturation. Increase in very young blasts (don't look myeloid). WBC is normal to slightly increased. (AML with minimal maturation). Myeloblasts dominate (blasts look myeloid). Very elevated WBC with few neutrophils. AML type. (AML with maturation). Myeloblasts are increased (blasts look myeloid). Very elevated WBC with many neutrophils. AML type. (APL- Acute Promyelocytic Leukemia). Increase in blasts but promyelocytes dominate. T(15:17) translocation, mutated retinoic acid gene (single gene defect). AML type. (AMML- Acute Myelomonocytic Leukemia). Myeloblasts and monoblasts co-dominate. Increased WBCs, neutrophils, and monocytes. AML type. (AMoL- Acute Monocytic Leukemia). Monoblasts dominate. Increased WBCs and monocytes. AML type. (AEL- Acute Erythrocyte Leukemia). Erythroblasts dominate (slightly increase in myeloblasts). Increased WBC and NRBCs. AML type. (AMegL- Acute Megakaryocytic Leukemia). Increased megakaryoblastic. Fibroblasts in bone marrow. PANCYTOPENIA. AML type. ALL type in which very young lymphoblasts dominate ALL type in which young lymphoblasts dominate ALL type in which slightly young lymphoblasts dominate ALL type in which mature lymphoblasts dominate ALL type in which T lymphoblasts dominate Leukemia with increased WBC, decreased RBC, Hct, and plts. Large nucleoli (> 3) and abundant cytoplasm Leukemia with increased WBC, decreased RBC, Hct, and plts. Small nucleoli (<2) and scant cytoplasm. disorders characterized by mutations in the lymph nodes or bone marrow Hodgkin's and Non-Hodgkins multiple myeloma and Waldenstrom's macroglobulinemia chronic lymphocytic leukemia and hairy cell leukemia lymphoproliferative disorder that starts in the lymph node (not BM) lymphoma characterized by swollen cervical node, less aggressive lymphoma in which any node can be swollen, very aggressive Increase in plasma cells in BM and PB. Mutation causes proliferation

M4 M5 M6 M7 Precursor B-cell ALL Common B-cell ALL Progenitor B-cell ALL Mature B-cell ALL T-cell type ALL Acute Myeloid Leukemia Acute Lymphocytic Leukemia Lymphoproliferative Disorders Lymphoma Plasma cell dyscrasias Chronic leukemia Lymphomas Hodgkin's Lymphoma Non-Hodgkin's Lymphoma Multiple Myeloma

of mature plasma cells (B cells). Increased infections and bone fractures. Increase in defective Ig. BM choking causes pancytopenia. Increase in plasmacytoid lymphs (immature) in BM and PB. Mutation Waldenstrom's causes proliferation of younger plasma cells. Increased infections, bone Macroglobulinemia fractures. Increase in defective Ig (IgM). BM choking causes pancytopenia. lymphproliferative disorder diagnosed by plasma cells in BM and PB, Plasma Cell Dyscrasias anemia, thrombocytopenia, roleaux, increased ESR, SPE (gamma region) and increased IgG. leukemia that is most common in the elderly. Slow, incideous onset Chronic Lymphocytic with few symptoms. Characterized by high WBC, monotonous lymph, Leukemia (CLL) smudge cells, mild anemia, and thrombocytopenia in end stage.