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Date: To: From: Wards: Reference Number: May 14, 2007 Board of Health Medical Officer of Health All
SUMMARY
Breastfeeding is the optimal method of feeding infants. Toronto Public Health (TPH) recommends exclusive breastfeeding to six months of age followed by the introduction of appropriate complementary foods and continued breastfeeding to two years and beyond. If breastfeeding is not undertaken, TPH considers infant formula an acceptable alternative. Modifications to infant formulas have been made in an attempt to create products that resemble breast milk and meet infants nutritional needs. However, infant formulas are missing the immune factors, hormones, antimicrobial agents, antioxidants and enzymes that make breast milk the ideal food for infants. The purpose of this report is to inform the Board of Health about the composition of breast milk compared to a typical infant formula. Financial Impact There are no financial implications from this report.
DECISION HISTORY
At the January 29, 2007 meeting, the Board of Health requested the Medical Officer of Health to report on the composition of breast milk compared to a typical infant formula and to list the ingredients in breast milk compared to a typical formula.
ISSUE BACKGROUND
The nutritional requirements of infants from birth to six months can be met exclusively through breast milk, with the exception of Vitamin D. In addition, breastfeeding provides immunological and emotional benefits for the growth and development of infants. TPH
Staff Report for Information Composition of Breast Milk Compared to Infant Formula 1
supports Health Canadas recommendations for exclusive breastfeeding for the first six months of life followed by the introduction of appropriate complementary foods and continued breastfeeding for up to two years and beyond. (1) Breastfeeding is rarely contraindicated, but there are some situations when alternative feeding methods are recommended. These include severe illness of the mother, maternal use of certain medications or intravenous drugs, maternal HIV infection, and infants with inborn errors of metabolism (e.g., galactosemia, PKU). Health Canada acknowledges that infant formulas are the most acceptable feeding alternative, if an infant is not breastfed. (1
& 2)
Recommendations for feeding infants are made by numerous organizations but ultimately, infant feeding decisions are made by the mother and family. Breastfeeding should be promoted to all women, together with information to enable an informed decision to be made. If a mother decides not to breastfeed, healthcare providers should support her decision and ensure that she can provide infant formula in a safe and nurturing way. (2)
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
In addition to fat, carbohydrate and protein, breast milk is rich in vitamins, minerals, enzymes, growth factors and anti-infective properties. The immunological protection available from breast milk is one of its unique qualities. (3) Appendix A shows the composition of early breast milk and mature breast milk. Appendix B summarizes the major components of breast milk and their functions.
to which a breastfeeding mother is exposed may find their way into breast milk. The presence of contaminants in breast milk should be addressed by reducing maternal exposure rather than avoiding breastfeeding. The presence of low level environmental contaminants in breast milk does not diminish the proven health benefits of breastfeeding for both mother and infant. (6)
Some infant formulas also contain compounds for which there are no recommended intakes, but which are present in breast milk. These include some amino acids, nonvitamins and the B-vitamin choline, and are added to some formulas with unknown clinical significance. (3, 9 & 10) Comparing the nutritional composition of breast milk and infant formula does not accurately reflect their nutrient availability. The bioavailability and use of breast milk components is more efficient than formula, from which only a small fraction of some nutrients are absorbed. (3 & 4) Immunologic & infection protection Immunological protection is available from breast milk but absent from formula. Studies have revealed a reduced incidence of a number of diseases, infections and conditions with breast feeding. (4 & 8) Studies suggest that dietary nucleotides have a role in the development of the immune and gastro-intestinal systems. Infant formula manufacturers seek to imitate the many nucleotides of breast milk in their formulas, and add them to some. (3 & 10) Living nature of breast milk Breast milk composition is continuously changing, but formula does not have the ability to adapt in this way. Generally, infant formula has a three year shelf life after which the ingredients deteriorate. (9) Infant safety Purchasing and preparing infant formula requires attention and skill as there are different forms of formula (e.g., liquid concentrate, ready to feed, powdered) and formulas for various stages of life (e.g., infant, follow-up). Errors in the selection or preparation of infant formula can result in impaired nutrition, or in some cases in health risk to the infant. TPH has documented many cases of incorrect preparation or use of infant formula which pose a risk to infant health. For example, liquid concentrate formula may be incorrectly used as a ready to feed formula. Formulas which require preparation are also subject to contamination if the proper procedures are not followed. (3 & 9) These concerns are heightened in Toronto, where ethnocultural diversity, language barriers, and literacy levels may be obstacles to safe selection, preparation and use of infant formula. Conclusion Modifications to infant formulas have been made over time in an attempt to create products that more closely resemble breast milk. The formulations create products that provide an acceptable alternative for feeding infants when breastfeeding is not recommended or when the mother does not choose to breastfeed. However, infant
Staff Report for Information Composition of Breast Milk Compared to Infant Formula 5
formulas are missing the immune factors, hormones, antimicrobial agents, antioxidants and enzymes that make breast milk the optimal food for infants.
CONTACT
Donalda McCabe (Director, Healthy Families) Phone: 416-338-6181 E-mail: dmcca@toronto.ca Joan Crookston (Manager, Health Families) Phone: 416-338-7409 E-mail: jcrooks@toronto.ca Joanne Gilmore (Manager, Healthy Families) Phone: 416-338-8708 E-mail: jgilmore@toronto.ca Evelyn Vaccari (Consultant, Nutrition Promotion, Healthy Families) Phone: 416-338-7072 E-mail: evaccar@toronto.ca
SIGNATURE
ATTACHMENTS
Appendix A: Composition of Early Breast Milk, Mature Breast Milk and Infant Formulas Appendix B: Major Components of Breast Milk and their Function Appendix C: Ingredient Listings and Labels for Three Infant Formulas
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
Appendix A:
Composition of Early Breast Milk, Mature Breast Milk and Infant Formulas
Constituent Early Milk (per 100 mL) (1-5 days) Energy, kcal 58 Lactose, g 5.3 Total nitrogen, mg 360 Protein nitrogen, mg 313 Non-protein nitrogen, mg 47 Total protein, g 2.3 Casein, mg 140 Alpha-lactalbumin, mg 218 Lactoferrin, mg 330 IgA, mg 364 Urea, mg 10 Creatine, mg -Total fat, g 2.9 Cholesterol, mg 27 Vitamins (Fat Soluble) Vitamin A, ug 89 Beta-carotene, ug 112 Vitamin D, ug -Vitamin E, ug 1280 Vitamin K, ug 0.2 Vitamins (Water Soluble) Thiamine, ug 15 Riboflavin, ug 25 Niacin, ug 75 Folic acid, ug -Pantothenic Acid, mg v Biotin, mg v Vitamin B6, ug 12 Vitamin B12, ng 200 Vitamin C, mg 4.4 Minerals and Trace Elements Calcium, mg 23 Sodium, mg 48 Potassium, mg 74 Iron, ug 45 Zinc, ug 540 Chloride, mg v Phosphorus, mg v Magnesium, mg v Copper, mg v Manganese, mg v Iodine, mg -Selenium, mg v Choline, mg -Cells Mature Milk (>30 days) 70 7.3 171 129 42 0.9 187 161 167 142 30 3.3 4.2 16 47 23 0.04 315 0.21 16 35 200 5.2 v v 28 26 4.0 28 15 58 40 166 v v v 0.052 0.026 -0.0018 -Nestle Formula 67 7.5g CHO v v v 1.5g ? ? --? ? 3.4 -60 ? 1 845 6 54 94 700 10 0.3 0.002 50 200 6 44 18 72 1000 540 44 24 4.7 0.054 0.01 0.008 0.002 16 Similac Formula 68 7.3g CHO v v v 1.4g ? ? --? ? 3.65 -60.9 ? 1.01 1300 5.4 68 100 710 10 0.304 0.003 40 170 6.1 53 16 71 1200 510 43 28 4.1 0.061 0.0034 0.0041 0.00155 11
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
Phagocytes v (macrophages) Lymphocytes v Anti-inflammatory Factors Prostaglandins v Cytokines/ chemokines v Growth factors v Enzymes Amylase v Lipase v Growth Factors/ Hormones Human growth factors v Cortisol, insulin, thyroxine v cholecystokinin (CCK) Prolactin v Lipids (Fat) Long-chain v polyunsaturated fatty acids Monounsaturated fatty v acids, g Triglycerides v Protein: Whey 90:10 whey/casein Immunoglobulins v Lysozyme v Taurine v Nucleotides, mg v Inositol, mg v
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
Growth factors Enzymes: Amylase Lipase Growth Factors/ Hormones: Human growth factors Cortisol, insulin, thyroxine cholecystokinin (CCK) Prolactin Lipids (Fat): Long-chain polyunsaturated fatty acids Free fatty acids Triglycerides Lactose:
Minerals: Protein: Whey Immunoglobulins Lactoferrin Lysozyme Taurine Casein Vitamins A, C, E: Water:
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
Formula 2: SIMILAC ADVANCE Step 1 with Omega-3 and Omega-6 Concentrate (Source: www.rosscanada.ca March 22, 2007) Ingredients: ((U)-D) water, evaporated or dry skim milk, lactose, high oleic safflower oil or high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, calcium carbonate, monoglycerides, soy lecithin, *M. alpina oil, potassium chloride, ascorbic acid, choline bitartrate, **C. cohnii oil, magnesium chloride, carrageenan, ferrous sulphate, taurine, minositol, cytidine 5'-monophosphate, d-alpha-tocopheryl acetate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, d-calcium pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, -carotene, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. May contain sodium chloride. * Source of Arachidonic Acid (ARA) ** Source of Docosahexaenoic Acid (DHA)
Approximate analysis Energy Protein Fat Linoleic Acid Linolenic Acid Arachidonic Acid Docosahexaenoic Acid Carbohydrate Ash Sodium Potassium Chloride Vitamin A Vitamin D3 Vitamin E Vitamin K1 Vitamin C Thiamine Riboflavin Niacin Vitamin B6 Folic Acid Vitamin B12 Pantothenic Acid Biotin Calcium Phosphorus Magnesium Iron Zinc Copper Manganese Iodine Selenium Units kJ (Cal) g g g g g g g g mg mg mg IU IU IU mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg mg Standard dilution/ 100 mL 285 (68) 1.4 3.65 0.55 0.072 0.013 0.005 7.3 0.4 16 71 43 203 40.5 2 0.0054 6.1 0.068 0.1 0.71 0.04 0.01 0.00017 0.304 0.003 53 28 4.1 1.2 0.51 0.061 0.0034 0.0041 0.00155 11
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
mg mg mg mg
Formula 3: Nestl Good Start with Omega-3 & Omega-6 - for babies 0-12+ months (Source: www.nestle-baby.ca March 22, 2007) Ingredients: Partially Hydrolyzed Reduced Minerals Whey Protein Concentrate (From Cow's Milk), Lactose, Corn Maltodextrin, Palm Olein, Soybean Oil, Coconut Oil, Minerals (Potassium Citrate, Potassium Phosphate, Calcium Chloride, Tricalcium Phosphate, Sodium Citrate, Magnesium Chloride, Ferrous Sulphate, Zinc Sulphate, Sodium Chloride, Copper Sulphate, Potassium Iodide, Manganese Sulphate, Sodium Selenate), High Oleic Safflower Oil Or High Oleic Sunflower Oil, M. Alpina Oil***, Vitamins (Sodium Ascorbate, Inositol, Choline Bitartrate, Alpha-Tocopheryl Acetate, Niacinamide, Calcium Pantothenate, Riboflavin, Vitamin A Acetate, Pyridoxine Hydrochloride, Thiamine Mononitrate, Folic Acid, Phylloquinone, Biotin, Vitamin D3, Vitamin B12), C. Cohnii Oil****, Trypsin, Taurine, Nucleotides (Cytidine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate, Adenosine 5'-Monophosphate, Disodium Guanosine 5'Monophosphate), Soy Lecithin, Ascorbyl Palmitate, Mixed Tocopherols, L-Carnitine. *** A Source Of Arachidonic Acid (ARA) **** A Source Of Docosahexaenoic Acid (DHA)
Staff Report for Information Composition of Breast Milk Compared to Infant Formula
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REFERENCES
1) Canadian Paediatric Society, Dietitians of Canada and Health Canada. Nutrition for Healthy Term Infants, Minister of Public Works and Government Services, Ottawa, 2005. Breastfeeding Committee of Canada. The Baby-Friendly Initiative in Community Health Services: A Canadian Implementation Guide, 2002. Riordan, J. Breastfeeding and Human Lactation (Third Edition), Jones and Barlett Publishers Inc., Sudbury, Massachusetts, 2005. Lawrence, R.A. and Lawrence, R.M. Breastfeeding: A Guide for the Medical Profession (Sixth Edition), Mosby Inc., USA, 2005. Friesen, R. and Innis, S.M. Trans Fatty Acids in Human Milk in Canada Declined with the Introduction of Trans Fat Food Labelling, The Journal of Nutrition, Vol 136: 2558-2561, 2006. Toronto Public Health. Environmental Threats to Children: Understanding Risks, Enabling Prevention, 2005. Canadian Food Inspection Agency. Letter to Industry: Requirements Related to Nutrition Information and Nutrition and Health Claims for Infant Formula, January 8, 2007. American Academy of Pediatrics. Breastfeeding and the Use of Human Milk. Pediatrics, Vol 115 (2): 496-506, 2005. Smith, L.J. Informed Decision Making in Infant Feeding Presentation, 2007 Heinz Infant Nutrition Institute. In-Touch Newsletter, Vol 21 (2), 2004.
2) 3) 4) 5)
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