devastating infectious diseases. Vision We envision a world where people live free from the threat of infectious disease. About Seattle BioMed Seattle BioMed is the largest, independent, non-prot research institute in the U.S. focused solely on the worlds most devastating infectious diseases. More than 330 strong, we are dedicated to reducing human suffering and saving lives by converting knowledge into solutions. Our research is the foundation for new vaccines, drugs and diagnostics that will benet those who need our help most: the 14 million who will otherwise die each year from infectious diseases. Disease Focus Emerging & Neglected Diseases African sleeping sickness Amebiasis Chagas disease Leishmaniasis Toxoplasmosis Malaria Tuberculosis Viral Diseases HIV/AIDS Inuenza
Printed on recycled paper. 2013 Seattle Biomedical Research Institute. 307 Westlake Avenue North, Suite 500 Seattle, Washington 98109-5219 USA Phone: 206.256.7200 Fax: 206.256.7229 - seattlebiomed.org 2012 Freedom from Infectious Disease ANNUAL REPORT Seattle Biomedical Research Institute is a 501(c)3 nonprot organization. Federal tax ID #91-0961784. Accelerating Progress Help us continue to accelerate. Letter from our President Growing up in apartheid South Africa, I was acutely aware of the burden of disease in poor communities. It fostered in me an intense desire to help end the scourge of infectious disease, a pursuit that ultimately brought me here, to Seattle BioMed. Every day, every one of our scientists focuses his or her passion and expertise on overcoming diseases that take a staggering toll on human life and national economies. We need vaccines, new drugs and diagnostics to end the threat of HIV/AIDS, tuberculosis (TB), malaria and other infectious diseases so prevalent in resource-poor countries. As a strong believer in the power of technology to alleviate human suffering, I have devoted my career to advancing technologies that address major health problems of the developed world. Today, I am excited to be leveraging this experience in a new direction. As Chair of the Board of Seattle BioMed since September 2012, I work with a passionate group of trustees who share the belief that technology applied to infectious disease can transform global health. We serve on the Board because we know that, in this institution, deadly diseases including HIV, tuberculosis and malariahave the full attention of some of the worlds top scientists. Seattle BioMeds integration of systems biology, immunology and infectious disease research is spurring insights and innovations that will accelerate the development of life- saving interventions not only by us, but also by research organizations around the world. Our recently approved ve-year strategic plan aims to further accelerate this progress by focusing on three broad areas where Seattle BioMed intends to bring value: inuence by creating new scientic knowledge that can be built upon, invent by partnering to develop practical and effective interventions, and educate by training future generations of scientic leaders and innovators. We know that the development of life-saving interventions relies upon insights into the nature of disease that only come through basic research. Such insights provide launching pads for invention as Seattle BioMed scientists test out the best ways to translate these research ndings into strategies that can overcome barriers to disease prevention and treatment. As an independent research institution, Seattle BioMed has the freedom to pursue the best opportunities to advance scientic knowledge and develop solutions to infectious diseases. This means we can take risks that academic institutions or commercial enterprises often forego, but risks that are still focused on tangible outcomes, such as vaccines for HIV, TB or malaria. Our unique independent position means we also need independent support. Translational research that bridges the gap between bench and bedsidethe invent focus of our new strategic planunfortunately receives limited support from traditional funding sources. This funding gap must be bridged if we are to truly accelerate progress. Through Seattle BioMed, private individuals and organizations have the opportunity to expedite scientic discovery and to advance basic research past the milestones needed to deliver new life-saving products to the eld in resource-poor countries. I invite you to join us in supporting these critical efforts. In just the past year, insights from Seattle BioMed scientists have revealed new approaches to the development of vaccines and drugs for HIV, TB, malaria and other parasitic diseases. New computational analyses have helped dene when someone infected with latent TB is at risk of developing active disease. A new TB gene interaction map is beginning to reveal signaling pathways that are involved with latent TB becoming active, which will lead lead to the identication of drug targets. In the HIV eld, new insights are revealing why most HIV vaccines fail to elicit broadly neutralizing antibodies, and how different vaccine designs affect the response of the innate immune system, the bodys rst line of defense against infection. In malaria, researchers have discovered how the parasite commandeers liver cells, an event that is critical for their initial growth in humans. Seattle BioMed researchers have also made strides in elucidating the structures of proteins from a variety of pathogens, providing a valuable resource for future development of drugs, vaccines and diagnostic tools. The 2012 Annual Report brings you highlights of progress made in the past year, and outlines work ahead based on our recently completed ve-year strategic plan that maps out the approaches that will guide both basic research and its translation into interventions that improve and save lives. I thank you for your support of our science this past year and invite you to continue investing in the discoveries generated at Seattle BioMed. Together, we can accelerate progress in the ght against HIV/AIDS, TB, malaria, and other infectious diseases. New tools and new thinking are needed, and Seattle BioMed generates both. I know of no better place to be, and no better time to be here. I am honored to be the new President of this institution and to lead from the strong foundation created by Dr. Ken Stuart as we apply cutting-edge tools to infectious disease research, and partner to translate those discoveries into interventions that can save lives. While Seattle is in our name, the focus of our work is global and so are our collaborations. One of the tools we apply is systems biology. By embracing the complexity of biology, systems approaches enable the rational design of new vaccines and drugs. Seattle BioMed has become the worlds rst research institute to undertake the full integration of systems biology, infectious disease research, and immunology under one roof. In doing so, we have thrown open the doors to accelerated progress. Letter from our Board Chair COMING TOGETHER TO ACCELERATE PROGRESS FOR GLOBAL HEALTH 2 1 Alan Aderem, Ph.D. President and Director Trevor Moody Chair, Board of Trustees three-dimensional structures of over 560 proteins from more than 40 bacterial, protozoan and viral pathogenssignicantly surpassing their contract goals and providing a valuable resource for the development of drugs, vaccine and diagnostic tools. This fall, SSGCIDs contract with the National Institute of Allergy and Infectious Diseases was renewed for another ve years, and SSGCID expects to both determine the structures of another 400 proteins and to work with collaborators to understand their particular functions in causing disease. Immune response Io T. Scientists at Seattle BioMed have broadened the understanding of how the body responds to TB by identifying how the bacterium activates cells that suppress the immune response necessary to ght off infection. An effective vaccine will not only need to stimulate a robust immune response, but also keep these suppressor cells in check. InvenI. Seattle BioMed scientists test the best ways to apply basic research ndings and partner to develop them into practical strategies for disease prevention and treatment. HIV and T-ceIIs. Seattle BioMed researchers recently discovered how a very small number of people are able to control their HIV infection and keep the virus in check. The key lies in the balance between two different types of T-cells. Scientists are now applying systems biology to understand the underlying mechanisms, which may reveal a new drug target for AIDS prevention. Mapping T gene inIeracIions. Seattle BioMed has embarked on a major project to map how TBs 200 control genes (transcription factors) determine the activity of its other 3,800 genesincluding those that control the bacterias latent state. Simultaneously, researchers have identied a signaling pathway critical to the bacterias exit from latency and entry into active disease. Seattle BioMed has already begun collaborations to develop drug-like molecules that inhibit this system. A drug that prevents the transition from latent to active TB would represent a giant step forward in the control of this deadly scourge, given that one third of the worlds population is latently infected with TB. AcceIeraIing cures !or severe maIaria. Seattle BioMed scientists, in collaboration with scientic groups at the University of Copenhagen and the University of Edinburgh, discovered how malaria parasites are able to bind to brain blood vessels and cause cerebral malariathe most lethal form of the disease. Identifying the molecules that allow malaria parasites to stick to the brain will accelerate the development of treatments. EducaIe. Seattle BioMed fosters a continuum of training and engages with students at all levels of learning, to inspire tomorrows biomedical pioneers and increase the capacity of our partners in resource-poor countries. MOVING FASTER TO IMPACT GLOBAL HEALTH Seattle BioMed is one of a handful of research organizations around the world that are pioneering the systems biology of infectious disease research. Every day, the scientists at Seattle BioMed strive to end the threat of infectious disease by inuencing how we think about those diseases, inventing new solutions, and educating the next generation of scientists and our community. Inuence. Insights into the nature of infections and the bodys response to them are the source of every new intervention against devastating diseases. In ways large and small, research ndings in 2012 from Seattle BioMed are changing how we think about infectious disease. EnabIing ceII suicide Io bIock maIaria. Malaria threatens over 40 percent of the global population, sickens hundreds of millions and kills hundreds of thousands of people a year, the majority of whom are children and pregnant women in Africa. Yet, no vaccine is available, and drug resistance is a growing problem. Seattle BioMed scientists have identied how malaria parasites manipulate liver cells, where they live during the early stages of infection, to ensure their growth and survival. Strikingly, the changes caused by parasitic infection are similar to the changes that occur when cells become cancerous. This suggests that some cancer drugs could be used to prevent malaria and minimize the development of drug-resistant parasites. eveaIing nev proIein sIrucIures. Over the last ve and a half years, the Seattle Structural Genomics Center for Infectious Disease (SSGCID), a large-scale collaboration led by Seattle BioMed, has solved the Seattle BioMed initiatives supported the scientic education of over 1,100 trainees, including visiting scientists, postdoctoral scientists, graduate students, undergraduate interns, work-study students, high school students, and teachers. Of these, more than 900 students were from Washington State high schools that engaged with the on-site BioQuest program. Thirty eight percent of BioQuest Academy students this past summer were from backgrounds underrepresented in the sciences. The Seattle-India Joint Research Training Program on Global Infectious Diseases hosted a two and a half day workshop on tuberculosis in New Delhi with 24 trainees. Discussions and lectures covered a variety of topics including drug discovery, immunology, drug resistance, and research ethics. The program also hosted two young Indian TB scientists to train at Seattle BioMed. India is estimated to have over three million cases of tuberculosis with 320,000 deaths in 2011. More than 64,000 of those cases are estimated to have multiple drug resistance. Opposite: More than 40% of the worlds population is at risk for contracting malaria, and children are at the highest risk. A child in Africa dies from malaria every 60 seconds. Left: BioQuest Academy students spend two weeks during the summer immersed in a real lab setting. Seventy ve percent of graduates go on to earn a degree in the sciences, and about 20% have come back to work at Seattle BioMed. Alexis Kaushansky, Ph.D., Stefan Kappe, Ph.D., and Joe Smith, Ph.D., are just three of the malaria researchers at Seattle BioMed pioneering new ways to accelerate the development of drugs and vaccines. 4 3 INFLUENCE, INVENT AND EDUCATE TO IMPROVE LIVES for preventative treatment long before symptoms emerge. Furthermore, being able to identify which latently infected individuals are likely to develop disease allows them to be recruited for vaccine trials, which can greatly reduce the cost of clinical trials, allowing researchers to more effectively evaluate vaccine candidates. In 2013, scientists will conduct additional studies on samples collected from throughout Africa to conrm these results. They will also use molecular genetics to examine the role of newly identied gene candidates in controlling TB infection. Detecting new targets for a malaria vaccine The malaria vaccine candidate most advanced in testing, RTS,S, is built on a single parasite surface protein, and has an efcacy rate of roughly 30 percent. To improve on this, Seattle BioMed scientists collaborated with the Institute for Systems Biology to discover new antigens on the surface of the malaria parasite. These antigens Biomedical researchers around the world have been working for decades to develop vaccines that can prevent HIV/AIDS, tuberculosis (TB), and malaria. But with no simple way of measuring in the blood whether a vaccine candidate is producing the desired immune response, the process of vaccine development is painfully slow, expensive, and riddled with obstacles. At Seattle BioMed, the integration of infectious disease research, immunology and systems biology is illuminating the path. New tools and new approaches are accelerating vaccine development against all three diseases. Systematically learning from TBs tricks Globally, someone falls ill from TB every four seconds, and someone dies from TB every 20 seconds. Now, new research by Seattle BioMed scientists and colleagues in South Africa has identied early indicators of whether someone latently infected with the bacteria will become sick. The breakthrough came from a study that involved 6,000 adolescents in Cape Town, South Africa. The study begins to address a particularly challenging trait of TB: its ability to remain latent within the lungs of an infected person, emerging suddenly from this dormancy to cause the active and contagious form of the disease. Did you know? South Africa is the epicenter of the collision between HIV and TB, representing one third of the worlds cases of co-infection. As many as 70% of South Africas TB patients are also HIV-positive. HIV lowers the immune response needed to ght off infections like TB, and the exceptionally high rates of both HIV and latent TB in South Africa create a perfect storm for co-infection. NEW TOOLS AND NEW THINKING At the outset of the study, all of the young people recruited were latently infected with TB, but none had active disease. Knowing that some small percentage of the youth were likely to progress to active TB, the researchers collected blood samples every six months for two years. By the end of that time, 35 of the adolescents had progressed to active disease. Using a systems approach, researchers then compared the blood samples of teens that did and did not develop active disease. Analyses revealed patterns of gene expression that appeared in people who progressed to disease up to 18 months before symptoms appeared. These biological markers should enable early detection of emerging disease in people with latent TB, allowing Above: Seattle BioMed scientists used systems approaches to generate the rst predicted genome- wide regulatory network for M. tuberculosis: a blueprint for the discovery of the most inuential genes in the pathogen. The size and number of lines connecting the turquoise dots represent the inuence of the control genescritical information for drug discovery. Opposite: Collaboration is a cornerstone of research at Seattle BioMed. Systems biologists and TB researchers like (left to right) Christoph Grundner, Ph.D., Lynn Amon, Ph.D., Smitha Shankar, M.S., Dan Zak, Ph.D., and David Sherman, Ph.D., are nding creative new ways to blend their expertise and develop new tools. 6 5 (continued on p. 7) COLLABORATORS could serve as additional targets for a vaccine, boosting its ability to protect against disease. Scientists are also using computational analysis to learn more about how the immune system responds to malaria and to discover more potential vaccine targets. Together, these studies could identify new vaccine candidates to improve or possibly replace RTS,S. Re-engineering vaccines In a ve-year multi-institutional collaboration led by Seattle BioMed, immunologists, virologists, structural biologists and computational designers collectively examined why so many candidate HIV/AIDS vaccines have failed to elicit neutralizing antibodies against the virus. The team discovered that previously tested vaccines fail to activate the cells that produce such antibodies. Scientists at Seattle BioMed have now designed new vaccine candidates to specically activate those cells. The vaccine has been successfully tested in the laboratory and is ready for testing in model systems. Meanwhile, Seattle BioMed scientists, in collaboration with scientists at the National Institutes of Health, have discovered how adding different components to a vaccine can change the character of the innate immune response that vaccine produces. Since the innate immune system then orchestrates the adaptive immune response, these insights will enable more effective vaccine design. Much of what we study at Seattle BioMed has implications for more than one disease. Seattle BioMed scientists are now applying new knowledge about better vaccine design to both HIV/AIDS and TB. Likewise, antibody work in HIV will be important for TB and malaria. As Seattle BioMed scientists work together more closely and bring the power of systems biology to bear, the pace of discovery will further accelerate. Conclusion Seattle BioMed research is proving the power and potential of systems approaches. Today, Seattle BioMed is one of the few places in the world that are aggressively integrating systems biology and immunology into its infectious disease research. We could neither do this, nor produce the stream of results seen in past years, without the help of our supporters. We thank them and we invite you to join our cause. Sustained support is needed to make the most of our scientists discoveries. Only then can we fully maximize the potential of systems approaches and rapidly accelerate the development of life-saving interventions. Together, we strive toward breakthroughs in the treatment and prevention of infectious disease. 8 7 United States Antigen Discovery, Inc. AttoDx, Inc. Baylor Research Institute Benaroya Research Institute at Virginia Mason Beth Israel Deaconess Medical Center Carnegie Institution Centers for Disease Control & Prevention Cincinnati Childrens Hospital Medical Center Clemson University Dana-Farber Cancer Institute Duke University Emerald BioStructures, Inc. Emory University Fox Chase Cancer Center Fred Hutchinson Cancer Research Center Haborview Medical Center Harvard University Howard Hughes Medical Institute Indiana University Infectious Disease Research Institute Institute for Systems Biology Intellectual Ventures J. Craig Venter Institute Johns Hopkins University Los Alamos National Laboratory Mayo Clinic National Institutes of Health Naval Medical Research Center New York University Northern Illinois University Northwestern University Oregon Health and Sciences University Pacic Biosciences Pacic Northwest National Laboratory PATH Polyclinic Princeton University Public Health - Seattle & King County Ra Pharmaceuticals, Inc. Ragon Institute Rhode Island Hospital Rockefeller University Sage Bionetworks Seattle Childrens Hospital Sequella, Inc. St. Jude Childrens Research Hospital Stanford University Statistics Collaborative, Inc. Texas A & M University The Scripps Research Institute Tulane University U.S. Environmental Protection Agency University of California, Berkeley University of California, Irvine University of California, San Diego University of California, San Francisco University of Georgia University of Iowa University of Maryland University of Michigan University of Missouri-Kansas City University of North Carolina University of Pennsylvania University of Rochester University of San Diego University of South Florida University of Texas Health Science Center at Tyler University of Texas Southwestern Medical Center at Dallas University of Virginia University of Washington Vanderbilt University Walter Reed Army Institute of Research Walter Reed Army National Military Medical Center Washington State University Washington University in St. Louis Yale University Yecuris Corporation International Australian National University, Australia Barcelona Centre for International Health Research, Spain Centro de Investigaciones Biolgicas, CSIC, Spain Charit-Universittsmedizin Berlin, Germany Christian de Duve Institute of Cellular Pathology, Belgium Egerton University, Kenya ETH-Zurich (Swiss Federal Institute of Technology Zurich), Switzerland Foundation for Innovative New Diagnostics, Switzerland Grifth University, Australia The Hospital for Sick Children, Canada Imperial College London, UK Institut de Recherches Cliniques de Montral, Canada Institut Pasteur, France Institut Pasteur, Korea Institute of Parasitology, ASCR, Czech Republic Instituto de Parasitologa y Biomedicina Lpez - Neyra, CSIC, Spain International AIDS Vaccine Initiative International Centre for Diarrhoeal Disease Research, Bangladesh International Centre for Genetic Engineering and Biotechnology, India International Centre for Genetic Engineering and Biotechnology, Italy Jawaharlal Nehru University, India Kagawa University, Japan K-RITH (KwaZulu-Natal Research Institute for Tuberculosis and HIV), South Africa Mahidol University, Thailand McGill University, Canada Medical College, Kolkata, India Nanomics Biosystems Pty Ltd, Australia National Center for Drug Screening, China National Cheng Kung University, Taiwan The Netherlands Cancer Institute, The Netherlands Oxford University, UK Shanghai Institute of Materia Medica, China Southeast University, China Sun Yat-sen University, China TDR/World Health Organization Technion, Israel Third Military Medical University, China TriTryp Genome Consortium Universidad de Antioquia, Colombia Universidad del Valle, Colombia Universidade Federal de So Paulo, Brazil Universidade Federal de Viosa, Brazil Universidade Federal do Piau, Brazil Universit Laval, Canada University of Alberta, Canada University of British Columbia, Canada University of Cambridge, UK University of Cape Town, South Africa University of Copenhagen and Rigshospitalet, Denmark University of Dundee, UK University of Edinburgh, UK University of Erlangen-Nurnberg, Germany University of Glasgow, UK University of Lisbon, Portugal University of Nairobi, Kenya University of Queensland, Australia University of the Witwatersrand, South Africa University of Toronto, Canada University of Waikato, New Zealand Vrije Universiteit, The Netherlands Walter and Eliza Hall Institute of Medical Research, Australia Wellcome Trust Sanger Institute, UK Systems biologist John Aitchison, Ph.D. (center) and HIV researchers Leo Stamatatos, Ph.D. (left) and Don Sodora, Ph.D., are some of the researchers making strides towards a vaccine that activates the types of immune cells best equipped to ght off HIV. Of the 1.8 million deaths from HIV/AIDS per year worldwide, 1.2 million are in Africa. Thirty four million people globally are living with HIV. SEATTLE BIOMED LEADERS This is a publication of Seattle BioMeds Communications Department.
Photo credits: Kyle Minch, p. 6, Alan Aderem, p. 6 sidebar. 10 9 National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute of General Medical Sciences PATH Paul G. Allen Family Foundation American Lung Association Bill & Melinda Gates Foundation Burroughs Wellcome Fund Foundation for the National Institutes of Health Implicit Bioscience Ltd. Medicines for Malaria Venture Faculty Alan Aderem, Ph.D. President & Director John Aitchison, Ph.D. Professor & Director of Integrative Biology Nick Crispe, M.D., Ph.D. Professor Malcolm Gardner, Ph.D. Professor Christoph Grundner, Ph.D. Assistant Professor Helen Horton, Ph.D. Associate Professor Stefan Kappe, Ph.D. Professor & Program Director Peter Myler, Ph.D. Professor Marilyn Parsons, Ph.D. Professor, Program Director & Director of Professional Development David Sherman, Ph.D. Professor & Program Director Joseph Smith, Ph.D. Associate Professor Donald Sodora, Ph.D. Associate Professor Leo Stamatatos, Ph.D. Professor & Program Director Ken Stuart, Ph.D. Professor, Founder & President Emeritus Kevin Urdahl, M.D., Ph.D. Assistant Professor Ruobing Wang, M.D., Ph.D. Associate Professor Principal Scientists Andrew Oleinikov, Ph.D. Noah Sather, Ph.D. Daniel Zak, Ph.D. Senior Scientists Lynn Amon, Ph.D. Peter Askovich, M.D., Ph.D. Jason Carnes, Ph.D. Amy DeRocher, Ph.D. Alan Diercks, Ph.D. Mark Gilchrist, Ph.D. Elizabeth Gold, M.D. Ihn Kyung Jang, Ph.D Heather Jaspan, M.D., Ph.D. Bryan Jensen, Ph.D. Kathleen Kennedy, Ph.D. Vladimir Litvak, Ph.D. Sebastian Mikolajczak, Ph.D. Brian Oliver, Ph.D. Stephen Ramsey, Ph.D. Tige Rustad, Ph.D. Ramsey Saleem, Ph.D. Frank Schmitz, M.D., Ph.D. Shahin Shaani, Ph.D. Ashley Vaughan, Ph.D. Clinical Trials Jim Kublin, M.D., Ph.D. Medical Director Sara Healy, M.D. Clinical Trial Investigator Angela Talley, M.D. Lead Trials Investigator Afliate Faculty Jerry Cangelosi, Ph.D. Professor University of Washington Peter Doherty, MVSc, Ph.D. Nobel Laureate University of Melbourne Rentala Madhubala, Ph.D. Director of Advanced Instrumentation Research Facility (AIRF) Jawaharlal Nehru University, New Delhi Rob Moritz, Ph.D Director of Proteomics Facility & Associate Professor Institute for Systems Biology Achim Schnaufer, Ph.D. Research Group Leader & Medical Research Council (MRC) Fellow University of Edinburgh, UK Management Alan Aderem, Ph.D. President & Director Tom Blackwell Director, Information Technology Karen Blchlinger, J.D., Ph.D. General Counsel Susan Brown Vice President, Institutional Advancement Louie Coffman Senior Vice President, Strategy & Business Development Randy Hassler Chief Operating Ofcer Drew House Senior Director, Finance Kent Irwin Director, Operations & Facilities Eileen Murphy Director, Program Management Jeanine Willis Director, Human Resources BioQuest Theresa Britschgi Director, BioQuest Council of Scientic Advisors Ra Ahmed, Ph.D. Director, Emory Vaccine Center Clifton E. Barry, III, Ph.D. Senior Investigator, Chief, Tuberculosis Research Section, NIAID, NIH Samuel I. Miller Ph.D., Professor of Medicine, Microbiology, Immunology and Genome Sciences, University of Washington. Michel C. Nussenzweig, M.D., Ph.D. Sherman Fairchild Professor, The Rockefeller University Investigator, HHMI Laboratory of Molecular Immunology Jeffrey V. Ravetch, M.D., Ph.D. Theresa and Eugene Lang Professor, The Rockefeller University; Head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology Bennett (Ben) M. Shapiro, M.D., Chair Director of Research, Retired, Merck Research Laboratories John W. Shiver, Ph.D. Vice President, Worldwide Basic Research Franchise Head, Vaccines, Merck Research Laboratories Mike Tyers, Ph.D. Professor, Institute for Research in Cancer and Immunology, University of Montreal Canada Research Chair in Systems and Synthetic Biology Thomas E. Wellems, M.D., Ph.D., Chief, Laboratory of Malaria and Vector Research NIAID, NIH National Institutes of Health: Eunice Kennedy Shriver National Institute of Child Health and Human Development Fogarty International Center National Center for Research Resources National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Diseases Sclavo Vaccine Association Silver Family Foundation United States Department of Defense Telemedicine & Advanced Technology Research Center United States-Israel Binational Science Foundation Alan Alhadeff Margaret Allen, M.D. Ellsworth Alvord, Jr., M.D. Mark Benjamin, Sc.D. J. Paul Blake Carol Bryan Vince Bryan Robert Bunting Alice Burgess John Creighton, Esq. Andrew Dale James Davie Nancy Duncan Bruce Easter Janet Lane Eaton Marlyn Friedlander Steve Gillis, Ph.D. Harris Hoffman James A. Johnson John King Alvin Kwiram, Ph.D Carol Lewis Jilan Liu, M.D., M.H.A. Katherine M. Lombardo Emeritus Board Gary McGlocklin Peter Miller, J.D. Susan Morgensztern Peggy Morrow Thomas ORourke Judy Pigott Gloria Pfeif Erick Rabins Thomas Ranken Chuck Robertson Gilbert Scherer Michael D. Stull Ezra Teshome Usha Varanasi, Ph.D. Tom Waldron Rick Weller, M.D., D.T.M. & H. Michelle A. Williams, Sc.D. Mary Williamson James Woods, Ph.D. Jeffrey Wortley Louis Yaseen Updated 1/2013 FUNDERS Fiscal year ending June 30, 2012 SELECT FI NANCI AL DATA 12 11 BOARD OF TRUSTEES Dean Allen Chief Executive Ofcer McKinstry Rosemary Barker Aragon Executive Director Pacic Hospital Preservation & Development Authority Mark Ashida*^ Vice Chair, Business Development Committee Chair Chief Executive Ofcer Symform Richard Bear Chief Financial Ofcer CRH Medical Corporation Jane A. Biddle, Ph.D. Technology Transfer Consultant Gregg Blodgett*^ Treasurer, Finance & Audit Committee Chair Director, Chief Financial Ofcer Booyami, Inc. Maud Daudon* Board Operations & Governance Committee Co-Chair President & CEO Seattle Metropolitan Chamber of Commerce Jane Hedreen* Advancement Committee Co-Chair Owner Flora & Henri Darryl Johnson*^ Secretary Former US Ambassador to Thailand & Lithuania Kevin F. Kelly, J.D. Business Consultant, Drug and Vaccine Collaborations Retired Partner, Cooley LLP Alan Levy, Ph.D. Venture Partner, Medical Devices Frazier Healthcare Ventures Neil McDonnell, PharmD Senior Vice President Cardiovascular & Metabolic Diseases Therapeutic Area Takeda Pharmaceuticals Terrence R. Meersman Vice President, Programs Margaret A. Cargill Foundation Trevor Moody*^ Chair President TM Strategic Advisors LLC Todd Patrick* Immediate Past Chair President & CEO C3-Jian, Inc. Christopher H. Porter, Ph.D. President Medical Genesis Alexandre Portet Deputy Director, Strategy Planning & Management Bill & Melinda Gates Foundation Kris Richey Curtis* Advancement Committee Co-Chair Vice President Kinzer Real Estate Services David R. Stewart, J.D. Executive Vice President & General Counsel Vulcan, Inc. Ken Stuart, Ph.D. President Emeritus & Founder Seattle BioMed Moya Vazquez* Board Operations & Governance Committee Co-Chair Community Volunteer Bryan White Managing Director & Chief Investment Ofcer BlackRock Alternative Advisors Melissa Yeager Chief Operating Ofcer Cardeas Pharma ^ Ofcer * Member of Executive Board Updated 1/2013 *Includes one-time contribution to support scientic expansion and leadership
Audited statements available upon request. Please e-mail connect@seattlebiomed.org. Statements of nancial position 2012 2011 Cash & investments $19,867,435 $21,203,046 Pledges receivable $263,797 $3,484,055 Other assets $7,719,694 $7,683,610 Property & equipment $9,488,075 $10,170,785 Total assets $37,339,001 $42,541,496 Accounts payable & accrued expenses $6,932,498 $4,704,532 Advances & deferred obligations $8,070,453 $10,335,651 Capital project debt $1,059,932 $2,608,351 Total liabilities $16,062,883 $17,648,534 Total net assets $21,276,118 $24,892,962 Statements of activities 2012 2011 Support & revenue Government grants $31,430,061 $27,858,893 Private grants $11,606,758 $12,599,217 Contributions $558,259 $7,621,585* Educational program $81,405 $99,442 Investment & other income $3,037,115 $3,394,990 Total support & revenue $46,713,598 $51,574,127 Expenses Research program $42,778,277 $38,947,458 Educational program $594,243 $869,233 Management & administrative $6,549,447 $6,080,604 Fundraising $408,474 $729,667 Total expenses $50,330,441 $46,626,962 Increase (decrease) in net assets ($3,616,843) $4,947,165 Revenue & support 2012 Contributions 1% Other income 6% Government Grants 69% Private Grants 24% Budget by program area HIV/AIDS 33% Emerging & Neglected Diseases 29% Malaria 32% Tuberculosis 6% 2012 2012 HONOR ROLL Thank you for your support. The 2012 donor list includes new pledges, outright gifts of cash and stock, pledge payments, and in-kind donations received from July 1, 2011, through June 30, 2012. Donors of $1,000 and above are listed on the donor wall at Seattle BioMed. Each of our donors is important to us. Please e-mail connect@seattlebiomed.org with any omissions or errors. 14 13 $1,000,000+ Bill & Melinda Gates Foundation James B. Pendleton Charitable Trust $50,000+ Dean & Vicki Allen/McKinstry Co. Charitable Foundation Washington State Department of Agriculture $25,000+ Byron & Alice Lockwood Foundation Gilbert Scherer & Marlyn Friedlander $10,000+ Drs. Alan Aderem & Kathy Barker Anonymous (2) Charles Spear Charitable Trust The Crystal Family Foundation James & Sarah Davie Richard & Elizabeth Hedreen KeyBank Foundation Todd & Julie Patrick Gloria Pfeif Judy Pigott Becky Roberts The Team Trio Fund In Honor & Remembrance of Dr. David Clemetson $5,000+ Perry, Christine, & Cooper Atkins Gregg & Jane Blodgett Maud & Marc Daudon David & Amy Fulton Gilead Sciences, Inc. Racha & Wassef Haroun Jane Hedreen & David Thyer Mike & Liz Hilton KeyBank National Association Kinzer Real Estate Services Lease Crutcher Lewis Petrizzo Bond, Inc. Gordon & Gretchen Raine Lucie Robitaille & Antoine Leblond Ronald & Sara Seubert Drs. Ken Stuart & Julie McElrath Mike & Sandra Stull Vulcan Inc. Wells Fargo Insurance Services Melissa Yeager & Cory Van Arsdale $2,500+ Dr. John & Leslie Aitchison Alexandria Real Estate Equities Inc. Mark Ashida & Lisbet Nilson ATS Automation The Baden Family Drs. Jane A. Biddle & Kenneth B. Seamon BioMed Realty Trust, Inc. Betty Bottler Bristol-Myers Squibb Co. Susan P. Brown Bullitt Foundation Concur Technologies, Inc. Firland Foundation GLY Construction Group Health Cooperative Betsy & Eric Hentz Jones Lang LaSalle Leroy Hood Mark Malamud & Susan Hautala Trevor J. Moody & Laura Hernon Moss Adams LLP NBBJ Christopher & Kathryn Porter Kris Richey Curtis Sabey Corporation Salal Credit Union Daniel D. Syrdal Kristin Tolle, Ph.D. Moya Vazquez VLST Corporation Jeanine Willis & Eric Freyberg Debra Wilson $1,000+ Anonymous (4) Kevin & Patrice Auld Richard Bear Bonnie Berk Steve & Marijo Brantner David Brenner Clark Nuber P.S. Paul & Debbie Cressman Earl & Anita Davie Patrick Duffy Renee Duprel Carolynn & Hal Ferris JoAnn & Barry Forman Greg Foster M. 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The people with the most inuence on global health are people like you. You have invested your time and money, and you have joined us on our journey to end the threat of infectious disease. Individuals, foundations and corporations that imagine a world free from this burden play a signicant role in enabling Seattle BioMed to expand research programs, recruit innovative scientists and form powerful collaborations that will ultimately lead to a healthier world. Mission Every day, we strive to eliminate the worlds most devastating infectious diseases. Vision We envision a world where people live free from the threat of infectious disease. About Seattle BioMed Seattle BioMed is the largest, independent, non-prot research institute in the U.S. focused solely on the worlds most devastating infectious diseases. More than 330 strong, we are dedicated to reducing human suffering and saving lives by converting knowledge into solutions. 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