Considered judgement on quality of evidence

Key question:

HBOT therapy improve symptoms of Autism and Autism related disease

1. Volume of evidence

Evidence table ref:

Comment here on any issues concerning the quantity of evidence available on this topic and its methodological quality.
-no clearly defined question -appears the paper is designed to debunk a previous study -no specific research base 2. Applicability

Comment here on the extent to which the evidence is directly applicable to the NHS in Scotland.
- the evidence was presented poorly and thus is not applicable to the NHS 3. Generalisability

Comment here on how reasonable it is to generalise from the results of the studies used as evidence to the target population for this guideline.
There was no specific target population. They used individuals with autism spectrum, PDD NOS and Aspergers. Only 16 people were used from any one of these three (while related they are not the same), diseases. 4. Consistency

Comment here on the degree of consistency demonstrated by the available of evidence. Where there are conflicting results, indicate how the group formed a judgement as to the overall direction of the evidence
The judgment was made before the study was done. The study was shown to be done after the study done by Rossinger et al. The results disprove the study. If the study were done independently of the other the results would be taken more seriously.

5. Clinical impact

Comment here on the potential clinical impact that the intervention in question might have e.g. size of patient population; magnitude of effect; relative benefit over other management options; resource implications; balance of risk and benefit.
If the intervention works, the impact is huge. It would change so many lives and the world. 6. Other factors

Indicate here any other factors that you took into account when assessing the evidence base.
I took into account the population, lack of a specific question, lack of p values, lack of

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confounding, and validity

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7. Evidence statement

Please summarise the development group's synthesis of the evidence relating to this key question, taking all the above factors into account, and indicate the evidence level which applies.

Evidence level

3B This is designed to be a case control study. The biggest problem is that there was no control

8. Recommendation

What recommendation(s) does the guideline development group draw from this evidence? Please indicate the grade of recommendation(s) and any dissenting opinion within the group.

Grade of recommendation

moderate The authors were convinced of their results. However based upon the results I have found, the article is being dismissed for any evidence.

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