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Preventive effect of vitamin C (L-ascorbic acid) on methylcholanthrene-induced soft tissue sarcomas Related Articles
in mice.
NTP Toxicology and Carcinogenesis of 1,2,3-Trichloropropane (CAS No.
[Nat(Gavage
96-18-4) in F344/N Rats and B6C3F1 Mice l To xicol Studies).
Pr ogr am TechRep Ser. 1993]
Abdel-Galil AM.
NTP Toxicology and Carcinogenesis Studies of Pentachloroanisole (CAS No.
1825-21-4) in F344 Rats and B6C3F1 Mice
[Nat(Feed Studies).
l To xicol Pr ogr am TechRep Ser. 1993]
The effect of vitamin C (L-ascorbic acid) on methylcholanthrene (MCA)-induced local malignant sarcomas in
mice was investigated. Four groups of mice were given single intramuscular application of MCA at a dose level NTP Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride
of 0.5 mg/0.1 ml olive oil for each animal. Doses of 6, 25, and 35 mg vitamin C (VC)/mouse were given to (CAS No. 20265-96-7) in F344/N Rats and
[NatB6C3F1
l To xicolMice
Pr ogr(Gavage
am TechStudies).
Rep Ser. 1989]
animals of groups B, C and D, respectively. VC was applied in drinking water by intragastric administration 5
NTP Toxicology and Carcinogenesis Studies of Phenolphthalein (CAS No.
times weekly for the first 20 weeks. Animals of group A served as carcinogenic controls. The application of VC
[Nat(Feed
77-09-8) in F344/N Rats and B6C3F1 Mice l To xicol Pr ogr am TechRep Ser. 1996]
Studies).
statistically prevented the induction of sarcomas in mice of groups B, C and D compared to carcinogenic
controls (group A). VC supplementation did not significantly reduce the diameters and weights of tumors. It Review Final report of the safety assessment of L-Ascorbic Acid, Calcium
was concluded that, under the experimental conditions conducted, VC significantly prevented the induction of Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium
[I nt JT oxicol. 2005]
sarcomas in mice providing a good prophylactic activity; however, it did not achieve a significant therapeutic
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level.
Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used
to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.
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