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1: EXS. 1992;62:398-410. Links

Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, Related Articles
ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study.
Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year
follow-up of the prospective Basel Study. [Am J Epi demiol. 1991]
Eichholzer M, Stähelin HB, Gey KF.
Poor plasma status of carotene and vitamin C is associated with higher mortality
Geriatric Clinic Kantonsspital, Basel, Switzerland. from ischemic heart disease and stroke: Basel Prospective Study.
[Clin In vestig. 1993]
Prediction of male cancer mortality by plasma levels of interacting vitamins:
There is accumulating evidence that free radicals may contribute to various diseases such as cancer or 17-year follow-up of the prospective Basel study. [ Int J Cancer. 1996]
cardiovascular disease. Possible health hazards can to some extent be prevented by the body's multilevel
defense system against free radicals, which comprises, besides others, antioxidant vitamins. The 12-year Review Increased risk of cardiovascular disease at suboptimal plasma
mortality follow-up of 2,974 participants of the Basal Study allowed to test the hypothesis that low antioxidant [Am with
concentrations of essential antioxidants: an epidemiological update J Clinspecial
Nutr. 1993]
vitamin plasma concentrations (vitamin A, C, E and carotene) were associated with increased death from Review Cardiovascular disease and vitamins. Concurrent correction of
cancer of various sites and death from atherosclerosis such as ischemic heart disease and stroke, respectively. 'suboptimal' plasma antioxidant levels may, as important part [Bib
of 'optimal'
lNutr Di eta. 1995]
For the analysis 204 cancer cases, 132 fatalities from ischemic heart disease (IHD) and 31 deaths from cerebral
vascular disease were available. Cancer mortality. Overall mortality from cancer was associated with low » See Reviews... | » See All...
mean plasma levels of carotene adjusted for cholesterol (p less than 0.01) and of vitamin C (p less than 0.01).
Bronchus and stomach cancers were associated with a low mean plasma carotene level (p less than 0.01).
Cited by PubMed Central articles
Subjects with subsequent stomach cancer had also lower mean vitamin C and lipid-adjusted vitamin A levels
than survivors (p less than 0.05). Calculating the relative risk with exclusion of mortality during the first two Passive smoking and heart disease. Authors need to analyse the same data.
years of follow-up, low plasma carotene was associated with an increased risk for bronchus cancer (RR 1.8, p [BMJ. 1998]
less than 0.05), and the small number of stomach cancer cases (RR 2.95, p less than 0.05) low plasma levels of Effects of chronic vitamin E deficiency and a high polyunsaturated fatty acid diet
carotene and vitamin A with all cancer types (RR 2.47, p less than 0.01), and low plasma retinol in older on rat mesenteric arterial function. [Br J Pha rmacol. 1995]
subjects (greater than 60 years) with lung cancer (RR 2.17, p less than 0.05). Studies in other cohorts with a
poor vitamin E status revealed an increased risk of subsequent cancer at low vitamin E levels as well. It is
concluded that low plasma levels of all major essential antioxidants are associated with an increased risk of Patient Drug Information
subsequent cancer mortality. Cardio-vascular mortality. Plasma carotene concentration below quartile 1 was
Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used
associated with an increased risk for IHD (RR 1.53, p = 0.02). The same was true for low levels of both carotene
to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.
and vitamin C (RR = 1.96, p = 0.022). The risk of cerebrovascular death was elevated in subjects with low
carotene in the presence of low vitamin C plasma concentration (RR 4.17, p less than 0.01). These data confirm Source: AHFS Consumer Medication Information
and extend recent findings on an inverse correlation of beta-carotene and vitamin C respectively to
CVD.(ABSTRACT TRUNCATED AT 400 WORDS)
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