CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Biobanking Informatics Infrastructure to Support Clinical and Translational Research

Bernie LaSalle
Biomedical Informatics Core Center for Clinical and Translational Research University of Utah

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

HRSA: 4 D1BRH20425-01-01 Joyce Mitchell/Bernie LaSalle

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

University of Utah - Steering Committee Joyce Mitchell Mary Bronner/Peter Jensen Jeff Botkin Jennifer Logan Scott Narus Ken Smith Michael Varner Brian Watts Bernie LaSalle Professional Staff
Carolyn Orthner Rick Bradshaw Aldo Bernasconi Randy Madson Ryan Butcher Dustin Schultz Roger Mariner Damon Treitler Ramkiran Gouripeddi Matt Whittkaer Mike Donnelly Cheri Hunter Vik Deshmukh

Intermountain Healthcare Steering Committee Marc Jackson Marc Williams Melissa Cessna David Neilson Scott Narus Nathan Hulse Kerry Rowe Brent Wallace Morris Linton Professional Staff
Kira Wagner Bhanu Iyer Jeff Ferraro Darin Wilcox John Holmen Pallavi Ranade

UD0H Barry Nangle

Supported in part by grants 1D1BRH20425 from HRSA and UL1R025764 from NCRR/NCATS.

Advisory

External
Ethics/Reg. Adv. Board

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Scientific Adv. Board

Public Adv. Board

Leadership/Oversight

Internal

HDROC

RGE

Management Committee

Mgmt & Ops

Ethics/Reg. Workgroup

Director & Staff

Public Engagement Workgroup

Informatics Workgroup

Data Warehouses & UPDB Workgroup

Biospecimen Workgroup

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Principles for Access to Biospecimens

Govern all biospecimens and associated meta data as an institutional asset. Work with Intermountain to maintain standard data models and definitions to accommodate searching across institutions.

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Aldo Bernasconi1 Jeffry Botkin3 Richard Bradshaw1 Melissa Cessna5 Nathan Hulse4,7 Mark Jackson4 Randy Madsen1
1 Department

Roger Mariner1 Joyce Mitchell1 Carolyn Orthner1 Louisa Stark3 Dustin Schultz1 Damon Treitler1 Michael Varner2

of Biomedical Informatics, 2 Department of Obstetrics and Gynecology, 3 Department of Human Genetics, 7 Nursing Informatics University of Utah, Salt Lake City, UT 84112

4 Maternal

Fetal Medicine, 5 Intermountain Biorepository, 6 Clinical Knowledge Management Intermountain Healthcare, Salt Lake City, UT 84111

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

FURTHeR
Empowers researchers with a linked virtual repository integrating biological sample, clinical and demographic data in real time

FURTHeR

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Support clinical and translational research On-the-fly real-time federation of health information from heterogeneous data sources Data source partners do not need to extract data and build a new database (another copy)
Remains in its native format Is as up-to-date as the data source

Join data from multiple sources for research

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Information Technology
Implementation of FQL at Intermountain
Query translation Data service Transport service

Secure query and payload transmission

Static VPN

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Information Technology
Federated security model
Access Control lists at both institutions
Secure authorization integrity

Iterative queries

Single result set

Patient demographic, clinical and biospecimen data

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Web application description for FURTHeR and Intermountain Healthcare data services
XML (FQL criterion)

Physical Query from FURTHeR Transport Service VPN Tunnel Result set from Intermountain to FURTHeR Web Services XML Application Logic Security Intermountain Data sources

FQL Translation

Requesting Query:
The query from FURTHeR takes advantage of Hibernate object relational mapping idioms marshaled in xml. Use of query criteria allows close one-to-one query execution from FURTHeR to Intermountain EDW.

Result Set:
The result set coming back to FURTHeR can be any structured representation of the entities. (Typically XML)

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

What we learned
Properly collected biospecimens add rich data to cohort queries
Standard terminologies Robust meta data
Collection protocols Searchable Consent forms

Governance Intellectual property

Summary

CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE BIOMEDICAL INFORMATICS CORE

Biospecimen data can be utilized

Determine cohorts Secondary data source from queries

There is significant value in adding biospecimens to phenotype and other data Biobanks are under utilized1 Opportunity within an between institutions
Scuedellari M., Biobank managers bemoan underuse of collected samples Nature Medicine 19, 253 (2013) http://dx.doi.org/10.1038/nm0313-253a